Relapsing Pulmonary Langerhans Cell Histiocytosis after Lung Transplantation

Etienne, Bénédicte; Bertocchi, M.; Gamondes, J. P.; Thevenet, F.; Boudard, C.; Wiesendanger, T; Loire, R; Brune, J; Mornex, Jean‐François

doi:10.1164/ajrccm.157.1.96-12107

Cited by 87 publications

(40 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A number of patients with very severe respiratory failure or major pulmonary hypertension have been treated with lung transplantation, with results similar to those found in patients with other patterns of diffuse infiltrating lung disease [73,74]. However, recurrence of the disease in the transplant within the first year has been reported, with possible risk factors being resumption of smoking and extrapulmonary involvement [73][74][75][76][77].…”

Section: Course and Prognosismentioning

confidence: 67%

See 1 more Smart Citation

Adult pulmonary Langerhans’ cell histiocytosis

Tazi¹

2006

Eur Respir J

283

297

View full text Add to dashboard Cite

Adult pulmonary Langerhans' cell histiocytosis is a rare disorder of unknown aetiology that occurs predominantly in young smokers, with an incidence peak at 20-40 yrs of age. In adults, pulmonary involvement with Langerhans' cell histiocytosis usually occurs as a single-system disease and is characterised by focal Langerhans' cell granulomas infiltrating and destroying distal bronchioles.High-resolution computed tomography (HRCT) of the chest is essential to the diagnosis, typically showing a combination of nodules, cavitated nodules, and thick-and thin-walled cysts. A high macrophage count in bronchoalveolar lavage (BAL) fluid is a common but nonspecific finding that merely reflects exposure to tobacco smoke. BAL is useful for eliminating infections and the other infiltrating lung disorders that can be seen in young adults. Langerhans' cells can be identified in BAL fluid, but, in contrast to what was initially hoped, this test shows a very low sensitivity and is rarely useful in the diagnosis of the disease.The definite diagnosis of pulmonary Langerhans' cell histiocytosis requires identification of Langerhans' cell granulomas, which is usually achieved by surgical lung biopsy at a site selected by chest HRCT. In practice, however, lung biopsy is performed on a case-by-case basis.No effective treatment is available to date, and improved understanding of the mechanisms involved in the pathogenesis of pulmonary Langerhans' cell histiocytosis is urgently needed, and should help in the development of specific therapeutic strategies for patients with this orphan disease.

show abstract

Section: Course and Prognosismentioning

confidence: 67%

“…Reports of recurrent disease in lungs transplanted into patients with PLCH are further evidence in favour of patient-related factors, the nature of which remain to be determined [73][74][75][76][77].…”

Section: Smoking and Plchmentioning

confidence: 99%

Adult pulmonary Langerhans’ cell histiocytosis

Tazi¹

2006

Eur Respir J

283

297

View full text Add to dashboard Cite

show abstract

“…Similarly, the relationship between smoking status and progression of the disease remains to be clari®ed. Radiological improvement and even complete resolution of PLCH after smoking cessation has been described in case reports [66,67]. Recurrence of PLCH in the transplanted lung has been seen in patients who resumed smoking after their lung transplantation [68].…”

Section: Pulmonary Langerhans' Cell Histiocytosismentioning

confidence: 99%

Smoking-related interstitial lung diseases: a concise review

Ryu¹,

Colby²,

Hartman³

et al. 2001

Eur Respir J

279

187

View full text Add to dashboard Cite

Interstitial lung diseases (also known as diffuse in®ltrative lung diseases) are a heterogeneous group of parenchymal lung disorders of known or unknown cause. These disorders are usually associated with dyspnoea, diffuse lung in®ltrates, and impaired gas exchange. The majority of interstitial lung diseases are of unknown cause. Known causes of interstitial lung disease include inhalation of organic and inorganic dusts as well as gases or fumes, drugs, radiation, and infections.This review summarizes the clinical, radiological, and histopathological features of four interstitial lung disorders that have been linked to smoking. These disorders include desquamative interstitial pneumonia, respiratory bronchiolitis-associated interstitial lung disease, pulmonary Langerhans' cell histiocytosis, and idiopathic pulmonary ®brosis. Available evidence suggests most cases of desquamative interstitial pneumonia, respiratory bronchiolitis-associated interstitial lung disease, and pulmonary Langerhans' cell histiocytosis are caused by cigarette smoking in susceptible individuals. Smoking cessation should be a main component in the initial therapeutic approach to smokers with these interstitial lung diseases. In addition, smoking appears to be a risk factor for the development of idiopathic pulmonary ®brosis. Eur Respir J 2001; 17: 122±132.

show abstract

“…LCH can behave as a neoplasm, with aggressive spread in the setting of mutations of tumor suppressor genes, familial clustering and growing in clonal populations [18,23]. After resection of visceral LCH, recurrence in the transplanted organs has been reported, which is particularly notable considering the strong immunosuppression required for lung and liver transplants [24,25]. …”

Section: Discussionmentioning

confidence: 99%

Resorption of PDLLA Plates as a Nidus for Recurrent Langerhans Cell Histiocytosis

et al. 2013

View full text Add to dashboard Cite

Resorbable plating systems have been adapted into routine use for craniofacial reconstruction in children. After implantation in some patients, the area around the plates can develop palpable and visible fibrous capsules, with underlying bone resorption and a significant foreign-body giant cell reaction. The reaction is usually self-limited. We report a case in which Langerhans cell histiocytosis was resected, and then recurred at the sites of resorbing plate and screw placement in association with a foreign-body giant cell reaction.

show abstract

Relapsing Pulmonary Langerhans Cell Histiocytosis after Lung Transplantation

Cited by 87 publications

References 9 publications

Adult pulmonary Langerhans’ cell histiocytosis

Adult pulmonary Langerhans’ cell histiocytosis

Smoking-related interstitial lung diseases: a concise review

Resorption of PDLLA Plates as a Nidus for Recurrent Langerhans Cell Histiocytosis

Contact Info

Product

Resources

About