Relapsing seronegative symmetrical synovitis with pitting oedema as a paraneoplastic manifestation of mesothelioma: A case report and review of the literature

Rondón-Carvajal, Julián; Lemus, Wilmer Javier Figueroa; Muñoz-Velandia, Óscar Mauricio

doi:10.1016/j.rcreue.2019.02.003

Cited by 3 publications

(6 citation statements)

References 8 publications

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“…Remitting seronegative symmetrical synovitis with pitting edema syndrome (RS3PE) is characterized by symmetrical polyarthritis, with a sudden onset of pitting edema over the extremities, especially in older ages, and males, with elevated CRP, ESR, and negative rheumatoid factor, and an excellent prognosis to treatment with steroids 4 , 5 , as in our case.…”

Section: Discussionmentioning

confidence: 53%

“…Its pathogenesis is not clear until now. Vascular endothelium-derived growth factor, which increases vascular permeability, may play a role as a major contributor to edema and synovitis, as well as IL-6, which is elevated in the synovial fluid of these patients, in addition to the HLA type, especially HLA B27, and infectious agents 4 , 5 , 11 , 12 .…”

Section: Discussionmentioning

confidence: 99%

“…The differential diagnoses include polymyalgia rheumatic and late-onset rheumatoid arthritis, and it coexists with cancer, and various rheumatic diseases, like Sjogren’s syndrome, ankylosing spondylitis, sarcoidosis, and others 5 , 10 .…”

Section: Discussionmentioning

confidence: 99%

“…Remitting seronegative symmetrical synovitis with pitting edema syndrome (RS3PE) was diagnosed according to the diagnostic criteria: age greater than or equal to 50 years, acute onset, pitting edema in the extremities with synovitis, and negative rheumatoid factor 5 . She was treated with 30 mg/day prednisolone, with a complete disappearance of edema and arthralgia after 10 days, and the CRP level was decreased.…”

Section: Case Presentationmentioning

confidence: 99%

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Remitting seronegative symmetrical synovitis with pitting edema syndrome postsecond COVID-19 vaccination: a case report

Hodifa,

Khalayli,

Hodaifa

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction and importance: Coronavirus disease 19 (COVID-19) has become the most serious public health crisis of our generation, and vaccines are effective in preventing its infection. Remitting seronegative symmetrical synovitis with pitting edema is an idiopathic rare benign syndrome, but it could be secondary to aautoimmune diseases. Here, the authors reported the first case of this syndrome’s development after COVID-19 vaccination. Case presentation: A 52-year-old woman presented with hand edema, arthralgia, and morning stiffness, after receiving the second dose of m RNA COVID-19 vaccination. Examination revealed edema in the dorsum of both hands and symmetrical tenderness of the shoulders, elbows, wrists, knees, and ankles. Blood test results were normal except for elevated levels of C-reactive protein. The immune profile and the tuberculin test were also negative. A hand radiograph showed soft tissue edema. Ultrasonography of the extremities has shown tenosynovitis. Remitting seronegative symmetrical synovitis with pitting edema syndrome was diagnosed according to the diagnostic criteria. She was treated with 30 mg/day prednisolone, with a complete disappearance of edema and arthralgia after 10 days, and the C-reactive protein level was decreased. Clinical discussion: Vaccines are still the most effective and protective method against COVID-19 infection, but it may trigger an immunological response. Remitting seronegative symmetrical synovitis with pitting edema (or sometimes RS 3 PE) is a rare nonunderstood syndrome identified by symmetric polyarthritis, synovitis, acute pitting edema of hands and/or feet, and a negative serum rheumatoid factor, with an excellent prognosis to treatment with steroid. Usually occurred in the old aged population, young patients’ cases were mentioned. As the authors did not find any data about our subject, this is the first case of this syndrome development after the second dose of COVID-19 vaccination. Conclusion: The occurrence of acute symmetrical seronegative polysynovitis with extremities edema, in the elderly, should guide toward the diagnosis of this syndrome.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Case Presentationmentioning

confidence: 99%

See 2 more Smart Citations

Remitting seronegative symmetrical synovitis with pitting edema syndrome postsecond COVID-19 vaccination: a case report

Hodifa,

Khalayli,

Hodaifa

et al. 2023

Annals of Medicine &Amp; Surgery

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“…Se caracteriza por: afectar sobre todo a varones mayores de 65 años, tener factor reumatoide negativo, tratarse de una polisinovitis simétrica que afecta a muñecas, MCF, IF proximales, vainas tendinosas de los extensores de las manos y edema con fóvea en dichas zonas. Además, tiene una muy buena respuesta al tratamiento con corticoides 1 , 2 .…”

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RS3PE: a propósito de un caso

2021

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Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome as a Manifestation of Recurrent Ovarian Cancer

et al. 2023

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We herein report a case of ovarian cancer recurrence detected every time with symptoms of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome. A 46-year-old woman who had a history of ovarian cancer 9 months earlier developed joint pain along with pitting edema in both hands and was diagnosed with RS3PE syndrome. Two and four years after initial surgery for ovarian cancer, symptoms of RS3PE syndrome appeared, and a recurrent site was detected. With resection of the relapsed sites and increased maintenance dose of methylprednisolone, these symptoms improved within a month.

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Relapsing seronegative symmetrical synovitis with pitting oedema as a paraneoplastic manifestation of mesothelioma: A case report and review of the literature

Cited by 3 publications

References 8 publications

Remitting seronegative symmetrical synovitis with pitting edema syndrome postsecond COVID-19 vaccination: a case report

Remitting seronegative symmetrical synovitis with pitting edema syndrome postsecond COVID-19 vaccination: a case report

RS3PE: a propósito de un caso

Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome as a Manifestation of Recurrent Ovarian Cancer

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