Related Factors and Clinical Outcomes of Osteosarcopenia: A Narrative Review

Inoue, Tatsuro; Maeda, Keisuke; Nagano, Ayano; Shimizu, Akio; Ueshima, Junko; Murotani, Kenta; Sato, Keisuke; Hotta, Kyoko; Morishita, Shinichiro; Tsubaki, Atsuhiro

doi:10.3390/nu13020291

Cited by 60 publications

(45 citation statements)

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“…27 Given that ageing is commonly associated with SP and OP, the aims of this study were (1) to explore associations between SP and OP, individually or in combination, with frailty in community-dwelling older adults participating in the Hertfordshire Cohort Study (HCS), and (2) to determine if coexistence of both SP and OP (osteosarcopenia) carries a higher likelihood of being frail. Given the importance of multimorbidity on health outcomes, 28 and the association that previously has been described between osteosarcopenia and chronic diseases, 29 we also considered (3) whether the coexistence of SP and OP was associated with a significantly heavier health burden, as assessed by the number of concurrent long-term conditions. The wealth of phenotypic information collected in the HCS, a cohort study of community-dwelling older adults, has allowed us to describe the prevalence and pre-frailty in this group and to consider whether the coexistence of SP and OP in individuals interacted to amplitude risk of frailty.…”

Section: Introductionmentioning

confidence: 99%

Associations of osteoporosis and sarcopenia with frailty and multimorbidity among participants of the Hertfordshire Cohort Study

Laskou

Fuggle

Patel

et al. 2021

J cachexia sarcopenia muscle

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Background Ageing is commonly associated with sarcopenia (SP) and osteoporosis (OP), both of which are associated with disability, impaired quality of life, and mortality. The aims of this study were to explore the relationships between SP, OP, frailty, and multimorbidity in community‐dwelling older adults participating in the Hertfordshire Cohort Study (HCS) and to determine whether coexistence of OP and SP was associated with a significantly heavier health burden. Methods At baseline, 405 participants self‐reported their comorbidities. Cut‐offs for low grip strength and appendicular lean mass index were used according to the EWSGOP2 criteria to define SP. OP was diagnosed when T‐scores of < −2.5 were present at the femoral neck or the participant reported use of the anti‐OP medications including hormone replacement therapy (HRT), raloxifene, or bisphosphonates. Frailty was defined using the standard Fried definition. Results One hundred ninety‐nine men and 206 women were included in the study. Baseline median (interquartile range) age of participants was 75.5 (73.4–77.9) years. Twenty‐six (8%) and 66 (21.4%) of the participants had SP and OP, respectively. Eighty‐three (20.5%) reported three or more comorbidities. The prevalence of pre‐frailty and frailty in the study sample was 57.5% and 8.1%, respectively. Having SP only was strongly associated with frailty [odds ratio (OR) 8.28, 95% confidence interval (CI) 1.27, 54.03; P = 0.027] while the association between having OP alone and frailty was weaker (OR 2.57, 95% CI 0.61, 10.78; P = 0.196). The likelihood of being frail was substantially higher in the presence of coexisting SP and OP (OR 26.15, 95% CI 3.13, 218.76; P = 0.003). SP alone and OP alone were both associated with having three or more comorbidities (OR 4.71, 95% CI 1.50, 14.76; P = 0.008 and OR 2.86, 95% CI 1.32, 6.22; P = 0.008, respectively) although the coexistence of SP and OP was not significantly associated with multimorbidity (OR 3.45, 95% CI 0.59, 20.26; P = 0.171). Conclusions Individuals living with frailty were often osteosarcopenic. Multimorbidity was common in individuals with either SP or OP. Early identification of SP and OP not only allows implementation of treatment strategies but also presents an opportunity to mitigate frailty risk.

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Section: Introductionmentioning

confidence: 99%

Associations of osteoporosis and sarcopenia with frailty and multimorbidity among participants of the Hertfordshire Cohort Study

Laskou

Fuggle

Patel

et al. 2021

J cachexia sarcopenia muscle

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“…Notably, bone and muscle tissue show strong interactions throughout life [7]. Osteoporosis and sarcopenia share common risk factors and contribute to a variety of negative health outcomes, such as falls and fractures, poor mobility, hospital admissions, morbidity, and mortality [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Both conditions may partly overlap and may be present in the same patient. Therefore, the term osteosarcopenia has been proposed to describe this overlap [2,10,19]. Osteosarcopenia is a unique syndrome that exacerbates negative health outcomes, causing a loss of independence and poor quality of life, especially in frail subjects [2,10].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the term osteosarcopenia has been proposed to describe this overlap [2,10,19]. Osteosarcopenia is a unique syndrome that exacerbates negative health outcomes, causing a loss of independence and poor quality of life, especially in frail subjects [2,10]. Although there are some prevalence data from geriatric inpatients, community-dwelling older individuals, or patients with a history of hip fractures [20][21][22], the prevalence of osteosarcopenia has not yet been fully researched.…”

Section: Introductionmentioning

confidence: 99%

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Osteosarcopenia, an Asymmetrical Overlap of Two Connected Syndromes: Data from the OsteoSys Study

et al. 2021

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Osteoporosis and sarcopenia are two chronic conditions, which widely affect older people and share common risk factors. We investigated the prevalence of low bone mineral density (BMD) and sarcopenia, including the overlap of both conditions (osteosarcopenia) in 572 older hospitalized patients (mean age 75.1 ± 10.8 years, 78% women) with known or suspected osteoporosis in this prospective observational multicenter study. Sarcopenia was assessed according to the revised definition of the European Working Group on Sarcopenia in Older People (EWGSOP2). Low BMD was defined according to the World Health Organization (WHO) recommendations as a T-score < −1.0. Osteosarcopenia was diagnosed when both low BMD and sarcopenia were present. Low BMD was prevalent in 76% and the prevalence of sarcopenia was 9%, with 90% of the sarcopenic patients showing the overlap of osteosarcopenia (8% of the entire population). Conversely, only few patients with low BMD demonstrated sarcopenia (11%). Osteosarcopenic patients were older and frailer and had lower BMI, fat, and muscle mass, handgrip strength, and T-score compared to nonosteosarcopenic patients. We conclude that osteosarcopenia is extremely common in sarcopenic subjects. Considering the increased risk of falls in patients with sarcopenia, they should always be evaluated for osteoporosis.

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“…Both sarcopenia and osteoporosis are geriatric diseases that decrease activity in daily living, and are interconnected physically and chemically. Recently, combined osteoporosis and sarcopenia are called "osteosarcopenia" [4]. Osteosarcopenia contributes to a high risk of falling, fracture, and even mortality [5].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Sarcopenia on Low Back Pain and Quality of Life in Patients with Osteoporosis

Iwahashi

Hashida

Matsuse

et al. 2021

Preprint

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Purpose: Osteoporosis combined with sarcopenia contributes to a high risk of falling, fracture, and even mortality. However, sarcopenia's impact on low back pain and quality of life (QOL) in patients with osteoporosis is still unknown. The purpose of this study is to investigate low back pain and QOL in osteoporosis patients with sarcopenia.Methods: We assessed 100 ambulatory patients who came to our hospital for osteoporosis treatment. Low back pain was evaluated using the Visual Analogue Scale (VAS) with 100 being an extreme amount of pain and 0 no pain. The Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) score was used to assess QOL after adjustment for age, history of vertebral fracture, and adult spinal deformity. Differences in low back pain intensity assessed by VAS between groups were evaluated by the Willcoxon rank-sum test. Covariance analysis was used to assess QOL. All data are expressed as either median, interquartile range, or average, standard error.Results: Patients were classified into the sarcopenia group (n=32) and the non-sarcopenia group (n=68). Low back pain intensity assessed by VAS was significantly higher in the sarcopenia group than in the non-sarcopenia group (33.0 [0-46.6] vs. 8.5 [0-40.0]; p<0.05). The subscales of the JOABPEQ for low back pain were significantly lower in the sarcopenia group than in the non-sarcopenia group (65.0±4.63 vs. 84.0±3.1; p<0.05). Conclusion:In this cross-sectional study, sarcopenia affected low back pain and QOL in ambulatory patients with osteoporosis. Sarcopenia may exacerbate low back pain and QOL. (244/250 words)

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Related Factors and Clinical Outcomes of Osteosarcopenia: A Narrative Review

Cited by 60 publications

References 44 publications

Associations of osteoporosis and sarcopenia with frailty and multimorbidity among participants of the Hertfordshire Cohort Study

Associations of osteoporosis and sarcopenia with frailty and multimorbidity among participants of the Hertfordshire Cohort Study

Osteosarcopenia, an Asymmetrical Overlap of Two Connected Syndromes: Data from the OsteoSys Study

The Impact of Sarcopenia on Low Back Pain and Quality of Life in Patients with Osteoporosis

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