2020
DOI: 10.1101/2020.07.01.182576
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Related Topics of a Novel TCR-based Cancer Detection Approach

Abstract: AbstractWe developed a novel algorithm (DeepCAT) to perform de novo detection of cancer associated TCRs, which is based on a convolutional neural network (CNN) model. In this manuscript, we compared its performance with a similar non-deep learning approach, TCRboost, and demonstrated that DeepCAT achieved better prediction accuracy when used to distinguish cancer from non-cancer individuals. Further, although DeepCAT was trained for CDR3s with different lengths, we showed that … Show more

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