Relatedness and heterogeneity at the near-terminal end of the genome of a parapoxvirus bovis 1 strain (B177) compared with parapoxvirus ovis (Orf virus)

Rziha, Hanns-Joachim; Bauer, B.; Adam, Karl-Heinz; Röttgen, Marlene; Cottone, R.; Henkel, Marco; Dehio, Christoph; Büttner, Mathias

doi:10.1099/vir.0.18850-0

Cited by 26 publications

(24 citation statements)

References 48 publications

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“…Variable PPV 126, 128, and 129 correspond to the Ank-1, Ank-2, and Ank-3 genes previously described for the BPSV B177 and ORFV D1701 strains (67). These ORFs are 58, 57, and 50% identical between BPSV and ORFV, respectively, and encode ankyrin repeat-containing proteins (ARPs).…”

Section: Resultsmentioning

confidence: 99%

“…Less is known about the gene complement and genomic organization of other PPV. DNA sequencing of the right end of the BPSV strain B177 genome indicated an organization similar to that of the right end of the ORFV genome, except for the lack of a vascular endothelial growth factor (VEGF) gene in BPSV (67). Here we present the complete DNA sequences of two ORFV isolates and one BPSV isolate, thus providing an overview of PPV genomic organization and gene content as well as a comparison between the two viruses.…”

mentioning

confidence: 99%

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Genomes of the Parapoxviruses Orf Virus and Bovine Papular Stomatitis Virus

Delhon

Tulman

Afonso

et al. 2004

J Virol

253

274

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Genomes of the Parapoxviruses Orf Virus and Bovine Papular Stomatitis Virus

Delhon

Tulman

Afonso

et al. 2004

J Virol

253

274

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“…The functional similarity, high amino acid identity and phylogenetic analyses of vIL-10 orthologues from ORFV, BPSV, Epstein-Barr virus, equid herpesvirus 2 with the corresponding sequences from their vertebrate hosts have suggested that these viruses have acquired the IL-10 gene from their hosts independently at different times during evolution (Hughes, 2002;Rziha et al, 2003;Delhon et al, 2004;Fleming et al, 2007). The carboxy two-thirds of PPV and cellular IL-10s are highly conserved, but with certain amino acid differences that are helpful in predicting the genetic origin of the sequence.…”

Section: Hautaniemi and Othersmentioning

confidence: 99%

The genome of pseudocowpoxvirus: comparison of a reindeer isolate and a reference strain

Hautaniemi

Ueda

Tuimala

et al. 2010

Journal of General Virology

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Parapoxviruses (PPV), of the family Poxviridae, cause a pustular cutaneous disease in sheep and goats (orf virus, ORFV) and cattle (pseudocowpoxvirus, PCPV and bovine papular stomatitis virus, BPSV). Here, we present the first genomic sequence of a reference strain of PCPV (VR634) along with the genomic sequence of a PPV (F00.120R) isolated in Finland from reindeer (Rangifer tarandus tarandus). The F00.120R and VR634 genomes are 135 and 145 kb in length and contain 131 and 134 putative genes, respectively, with their genome organization being similar to that of other PPVs. The predicted proteins of F00.120R and VR634 have an average amino acid sequence identity of over 95 %, whereas they share only 88 and 73 % amino acid identity with the ORFV and BPSV proteomes, respectively. The most notable differences were found near the genome termini. F00.120R lacks six and VR634 lacks three genes seen near the right terminus of other PPVs. Four genes at the left end of F00.120R and one in the middle of both genomes appear to be fragmented paralogues of other genes within the genome. VR634 has larger than expected inverted terminal repeats possibly as a result of genomic rearrangements. The high G+C content (64 %) of these two viruses along with amino acid sequence comparisons and whole genome phylogenetic analyses confirm the classification of PCPV as a separate species within the genus Parapoxvirus and verify that the virus responsible for an outbreak of contagious stomatitis in reindeer over the winter of 1999-2000 can be classified as PCPV.

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“…1A), seven have been described previously in ORFV (Fraser et al, 1990;Lyttle et al, 1994;Sullivan et al, 1995a;Fleming et al, 1997;McInnes et al, 2001;Rziha et al, 2003), two are orthologues of VACV genes and the remaining five appear unrelated to anything in the nucleotide or protein databases. Only two of the ORFV genes have had a function ascribed to them: those encoding the viral vascular-endothelial growth factor (VEGF) and viral IL-10 (Meyer et al, 1999;Wise et al, 1999;Fleming et al, 2000;Savory et al, 2000;Imlach et al, 2002).…”

mentioning

confidence: 99%

“…Analysis of the predicted amino acid sequences for membrane-spanning regions, signal peptides, DNA-binding regions and functional motifs and fingerprints yielded little clue to their function (results not shown). However two (ANK-2 and ANK-3) contain a number of ankyrin-like repeat elements (Rziha et al, 2003).…”

mentioning

confidence: 99%