Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome

Gambús, Pedro L.; Trocóniz, Iñaki F.; Feng, Xiaomei; Giménez-Milà, Marc; Mellado, Ricard; Degos, Vincent; Vacas, Susana; Maze, Mervyn

doi:10.1016/j.bbi.2015.07.005

Cited by 12 publications

(4 citation statements)

References 19 publications

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“…Interestingly, cognitive decline in both cases is closely related to the hippocampus [29, 30]. TFC is a widely used method to assess learning and memory function in rodents [31]. In this study, we found that surgery induced impairment in exploratory behaviour in old C57BL/6 wild-type mice, which was accelerated by 8-hour sleep disturbance before surgery.…”

Section: Discussionmentioning

confidence: 61%

Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice

Dong

Zhou

et al. 2019

Mediators of Inflammation

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Postoperative cognitive dysfunction (POCD) is defined as new cognitive impairment (memory impairment and impaired performance) after surgery, especially in aged patients. Sleep disturbance is a common phenomenon before surgery that has been increasingly thought to affect patient recovery. However, little is known about the functional impact of preoperative sleep disturbance on POCD. Here, we showed that tibial fracture surgery induced cognitive deficit and production of proinflammatory cytokines interleukin-6 (IL-6) and IL-1β, along with microglia and astrocyte activation, neuronal damage, and blood-brain barrier (BBB) disruption. Preoperative sleep disturbance enhanced the surgery-induced neuroinflammation, neuronal damage, BBB disruption, and memory impairment 24 h after surgery. Taken together, these results demonstrated that preoperative sleep disturbance aggravated postoperative cognitive function in aged mice and the mechanism may be related to central nervous system (CNS) inflammation and neuronal damage.

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Section: Discussionmentioning

confidence: 61%

Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice

Dong

Zhou

et al. 2019

Mediators of Inflammation

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“…Hippocampal-dependent learning and memory tasks were assessed by trace fear conditioning (TFC) as previously described ( Konopka et al, 2010 ; Gambus et al, 2015 ) with minor modifications. TFC training and testing were carried out in a room with overhead fluorescent light and a ventilation fan providing background noise (65 db).…”

Section: Methodsmentioning

confidence: 99%

Sevoflurane Induces Exaggerated and Persistent Cognitive Decline in a Type II Diabetic Rat Model by Aggregating Hippocampal Inflammation

Liu

et al. 2017

Front. Pharmacol.

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Recent studies show that a moderate duration of sevoflurane, one of the most commonly used volatile anesthetics in clinical practice, does not induce cognitive impairment in animals under physiological conditions. However, the influence of sevoflurane on cognitive function under diabetic conditions remains unclear. The aim of this study was to determine whether sevoflurane causes cognitive decline in a rat model of type 2 diabetes mellitus (DM) and if so, to explore a possible underlying mechanism. Diabetic Goto–Kakizaki (GK) rats and non-diabetic Wistar rats underwent 2.6% sevoflurane for 4 h or sham (control) exposure. Cognitive function and hippocampal inflammation were assessed 1 week and 5 months after sevoflurane or sham exposure. Compared with Wistar control rats, GK control rats exhibited shorter freezing times in Trace fear conditioning task 1 week after exposure, took longer to locate the submerged platform and had shorter dwell-time in the target quadrant in Morris Water Maze task 5 months after exposure. GK rats that received sevoflurane not only exhibited less freezing times 1 week after exposure, but also spent more time to locate the submerged platform and had less dwell-time in the target quadrant, compared with GK control rats. Molecular studies revealed that the levels of pro-inflammatory cytokines and activated microglia in the hippocampus were higher in GK control rats than those in Wistar control rats at both time points and were further increased in GK rats receiving sevoflurane. Wistar rats that received sevoflurane and Wistar control rats did not differ in any cognitive performance and molecular assessment. The results suggest that diabetic GK rats exhibit cognitive dysfunction probably due to increased hippocampal inflammation, and that sevoflurane induces exaggerated and persistent cognitive decline in GK rat by aggregating hippocampal inflammation.

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“…In this study, ICR mice of 12−14 months were used to avoid failure on behavioral tests, due to age-related incompetency. Meanwhile, other studies used mice of the same age ( Gambus et al, 2015 ; Li et al, 2016 ; Wang et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of different types of non-cardiac surgical trauma on hippocampus-dependent memory and neuroinflammation

Yuan

et al. 2022

Front. Behav. Neurosci.

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BackgroundOlder individuals have been reported to suffer from cognitive disorders after surgery. Various types of surgical trauma have been used to establish postoperative cognitive dysfunction (POCD) animal models in preclinical studies. However, few comparative analyses of these animal models were conducted.MethodsTibial surgery, abdominal surgery, and extended abdominal surgery were performed on aged ICR mice to establish POCD models. Behavioral tests included open field, novel object recognition, fear conditioning, and Morris water maze tests. The Z-score methodology was adopted to obtain a comprehensive and integrated memory performance profile. The changes in hippocampal neuroinflammation were analyzed by ELISA, PCR, and immunofluorescence.ResultsIn this study, we found that each type of non-cardiac surgical trauma has a different effects on locomotor activity. Tibial and extended abdominal surgeries led to more significant cognitive impairment than abdominal surgery. Inflammatory cytokines peaked on postoperative day 1 and decreased to control levels on days 3 and 7. Hippocampal neuroinflammation indicators between the three surgery types on postoperative day 1 had no statistical differences.ConclusionOverall, the type and intensity of non-cardiac surgical trauma can affect cognitive behavioral outcomes and central inflammation. The shortcomings and emerging issues of POCD animal research methods need to be further studied and solved.

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Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome

Cited by 12 publications

References 19 publications

Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice

Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice

Sevoflurane Induces Exaggerated and Persistent Cognitive Decline in a Type II Diabetic Rat Model by Aggregating Hippocampal Inflammation

Effects of different types of non-cardiac surgical trauma on hippocampus-dependent memory and neuroinflammation

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