Relation between baroreflex sensitivity and carotid artery elasticity in healthy humans

Bonyhay, Istvan; Jokkel, Gabor; Kollai, Márk

doi:10.1152/ajpheart.1996.271.3.h1139

Cited by 73 publications

(77 citation statements)

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“…Previous investigations have demonstrated that BRS is significantly related to carotid artery distensibility. A positive association between the elastic properties of the carotid artery and BRS has been reported in healthy volunteers, 25 pregnant women, 26 hypertensive subjects, 27 and nondiabetic patients with carotid artery stenosis. 28 However, in this study we did not observe any correlation between BRS and common carotid artery wall distensibility in T2DM patients with at least 2 additional cardiovascular risk factors.…”

Section: Discussionmentioning

confidence: 90%

“…In the comparative nondiabetic group with similar degree of arterial stiffening as evidence by equally elevated PWV and reduced carotid distensibility, a positive but weak correlation was observed between carotid distensibility and BRS, confirming previous observations in the nondiabetic group of subjects. [25][26][27][28] There are several aspects of the study that deserve clarification to properly interpret the data. First, spontaneous baroreflex sensitivity estimation using the alpha index and the sequence techniques may have a different meaning compared with the traditional phenylephrine method.…”

Section: Discussionmentioning

confidence: 99%

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Diabetic Neuropathy Is a More Important Determinant of Baroreflex Sensitivity Than Carotid Elasticity in Type 2 Diabetes

et al. 2005

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Abstract-The object of this study was to evaluate the contribution of carotid distensibilty on baroreflex sensitivity in patients with type 2 diabetes mellitus with at least 2 additional cardiovascular risk factors. Carotid distensibility was measured bilaterally at the common carotid artery in 79 consecutive diabetic patients and 60 matched subjects without diabetes. Spontaneous baroreflex sensitivity assessment was obtained using time and frequency methods. Baroreflex sensitivity was lower in diabetic subjects as compared with nondiabetic control subjects (5.25Ϯ2.80 ms/mm Hg versus 7.55Ϯ3.79 ms/mm Hg; PϽ0.01, respectively). Contrary to nondiabetic subjects, diabetic subjects showed no significant correlation between carotid distensibility and baroreflex sensitivity (r 2 ϭ0.08, Pϭ0.04 and r 2 ϭ0.04, Pϭ0.13, respectively). In diabetic subjects, baroreflex sensitivity was significantly lower in subjects with peripheral neuropathy than in those with preserved vibration sensation (4.1Ϯ0.5 versus 6.1Ϯ0.4 ms/mm Hg, respectively; Pϭ0.005). Age in nondiabetic subjects, diabetes duration, systolic blood pressure, peripheral or sensitive neuropathy, and carotid distensibility were introduced in a stepwise multivariate analysis to identify the determinants of baroreflex sensitivity. In diabetic patients, neuropathy is a more sensitive determinant of baroreflex sensitivity than the reduced carotid distensibility (stepwise analysis; F ratioϭ5.1, Pϭ0.028 versus F ratioϭ1.9, Pϭ0.16, respectively). In diabetic subjects with 2 additional cardiovascular risk factors, spontaneous baroreflex sensitivity is not related to carotid distensibility. Diabetic subjects represent a particular population within the spectrum of cardiovascular risk situations because of the marked neuropathy associated with their metabolic disorder. Therefore, neuropathy is a more significant determinant of baroreflex sensitivity than carotid artery elasticity in patients with type 2 diabetes.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Diabetic Neuropathy Is a More Important Determinant of Baroreflex Sensitivity Than Carotid Elasticity in Type 2 Diabetes

et al. 2005

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“…17,28 Even in young healthy subjects, decreased BRS is associated with decreased carotid artery distensibility. 29 Arterial distensibility is decreased in borderline as well as in established essential hypertension. 30 Various metabolic and lifestyle factors affect arterial properties and BRS.…”

Section: Discussionmentioning

confidence: 99%

Increased pulse pressure is associated with reduced baroreflex sensitivity

et al. 2004

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Although pulse pressure (PP), heart rate variability (HRV) and baroreflex sensitivity (BRS) have been shown to predict cardiovascular events and mortality in various populations, their relationships have not been clarified. We examined these associations in two separate population-based samples of healthy middle-aged subjects. In population 1, data were obtained from 149 subjects (71 men and 78 women) aged 35-64 (mean 47.7) years, and in population 2, from 214 subjects (88 men and 126 women) aged 40-62 (mean 50.5) years. Increased 24-h ambulatory PP was related to decreased cross-spectral BRS independent of age and gender (b ¼ À0.28, Po0.001 for population 1; b ¼ À0.22, P ¼ 0.003 for population 2). This association remained significant when 24-h ambulatory diastolic blood pressure, body mass index, smoking and alcohol intake were added as covariates in the multivariate analysis. Increased ambulatory PP was also associated with increased beat-to-beat systolic arterial pressure variability. Associations between ambulatory PP and HRV were not significant after controlling for age and gender. Our results suggest that elevated PP does not affect overall HRV, but it interferes with baroreflex-mediated control of the heart rate. This association may be due to a common denominator, such as arterial stiffness, for PP and BRS.

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“…12 A relation between BRS and carotid distensibility has been shown in healthy subjects and in hypertensive patients. [13][14][15] With advancing age, both BRS and carotid compliance were found to decrease, and the reduction in BRS was explained in part by stiffening of the arterial wall. 7 It is not known, however, how changes in large-artery compliance influence cardiovagal autonomic function during the childhood years.…”

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confidence: 99%

Maturation of Cardiovagal Autonomic Function From Childhood to Young Adult Age

et al. 2004

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Background-Cardiovagal autonomic control declines with age in adult subjects, which is related in part to increasing stiffness of the barosensory vessel wall. It is not known, however, whether autonomic function changes with age in children. Methods and Results-We studied 137 healthy subjects divided into 4 age groups: group 1, 7 to 14 years; group 2, 11 to 14 years; group 3, 15 to 18 years; and group 4, 19 to 22 years. Brachial artery pressure was measured by sphygmomanometry and continuous radial artery pressure and carotid artery pulse pressure (⌬P) by applanation tonometry. The R-R interval was derived from the ECG. Autonomic function was assessed by spontaneous sequence and frequency-domain indices, which indicate the extent of coupling between fluctuations in heart rate and systolic pressure. Carotid artery diastolic diameter (DD) and pulsatile distension (⌬D) were measured by echo wall tracking; carotid compliance coefficient (CC) was defined as ⌬D/⌬P and distensibility coefficient as 2⌬D/DD · ⌬P. , with no significant changes afterward. CC and DC were inversely proportional to age (rϭϪ0.49 and Ϫ0.62, respectively, PϽ0.001). The efficiency of neural integrative mechanisms, estimated as the ratio of spontaneous indices and CC, more than doubled from group 1 to group 3. Spontaneous indices were linearly related to measures of cardiac vagal activity. Conclusions-The increase in spontaneous indices from early childhood to adolescence, despite gradual stiffening of the carotid artery, may indicate improved cardiovagal autonomic function, which is most likely a result of maturation of neural mechanisms, attaining peak level at adolescence.

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Relation between baroreflex sensitivity and carotid artery elasticity in healthy humans

Cited by 73 publications

References 0 publications

Diabetic Neuropathy Is a More Important Determinant of Baroreflex Sensitivity Than Carotid Elasticity in Type 2 Diabetes

Diabetic Neuropathy Is a More Important Determinant of Baroreflex Sensitivity Than Carotid Elasticity in Type 2 Diabetes

Increased pulse pressure is associated with reduced baroreflex sensitivity

Maturation of Cardiovagal Autonomic Function From Childhood to Young Adult Age

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