Relation between bone erosions and rheumatoid factor isotypes.

Arnason, J A; Jónsson, Þorbjörn; Brekkan, A; Sigurjónsson, K; Valdimarsson, H.

doi:10.1136/ard.46.5.380

Cited by 49 publications

(18 citation statements)

References 18 publications

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“…In contrast, the lack of correlation between IgA-RF levels and clinical status conflicts with previous reports that IgA-RF is associated with disease activity (23)(24)(25). It should also be noted that, in some of the latter studies, the patients had early disease (23), and in others, the study populations included patients with rheumatic diseases other than RA (24,25). In contrast, our patients had well-established RA, and the treatment modality may have influenced the results.…”

Section: Discussioncontrasting

confidence: 81%

“…These results are consistent with those of previous studies indicating a relationship between IgM-RF levels and clinical status (2b22). In contrast, the lack of correlation between IgA-RF levels and clinical status conflicts with previous reports that IgA-RF is associated with disease activity (23)(24)(25). It should also be noted that, in some of the latter studies, the patients had early disease (23), and in others, the study populations included patients with rheumatic diseases other than RA (24,25).…”

Section: Discussioncontrasting

confidence: 67%

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Suppression of rheumatoid factor production by methotrexate in patients with rheumatoid arthritis: Evidence for differential influences of therapy and clinical status on IgM and IgA rheumatoid factor expression

Alarcón

Schrohenloher

Bartolucci

et al. 1990

Arthritis & Rheumatism

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Suppression of rheumatoid factor (RF) production in rheumatoid arthritis (RA) has been variably attributed to the use of remittive agents per se or to clinical improvement associated with their use. There have been conflicting reports with regard to the influence of methotrexate (MTX) on serum RF levels in RA. We determined IgM‐RF and IgA‐RF levels in paired serum samples (obtained at study entry and completion) from RA patients enrolled in multicenter trials with the Cooperative Systematic Studies of Rheumatic Diseases program. After exclusion of the 14 IgM‐RF‐negative sera, there were samples from 30 MTX‐treated patients and 52 placebo‐treated patients. Changes in IgM‐RF and IgA‐RF levels were weakly associated with each other. Significant decreases in IgM‐RF levels were observed in the MTX‐treated patients, but not in the placebo group. These changes were most significant in the MTX‐treated patients who improved clinically. There were significant decreases in IgA‐RF levels at study completion among MTX‐treated patients who had improved clinically and those who had not improved clinically, but not in the placebo group. The contributions of clinical improvement and MTX treatment to changes in serum IgM‐RF and IgA‐RF levels were examined using a logistic regression model. Changes in IgM‐RF were strongly related to MTX treatment and, to a lesser extent, to clinical improvement; changes in IgA‐RF were related only to MTX treatment. These results indicate that MTX treatment per se decreases both IgM‐RF and IgA‐RF levels, whereas clinical improvement correlates with decreased IgM‐RF levels only. The data are consistent with the view that MTX exerts a direct effect on RF production, which may reflect an important therapeutic action of this agent.

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Section: Discussioncontrasting

confidence: 81%

Section: Discussioncontrasting

confidence: 67%

Suppression of rheumatoid factor production by methotrexate in patients with rheumatoid arthritis: Evidence for differential influences of therapy and clinical status on IgM and IgA rheumatoid factor expression

Alarcón

Schrohenloher

Bartolucci

et al. 1990

Arthritis & Rheumatism

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“…IgA-RF has also been demonstrated in mucosal fluids ofpatients with RA [2]. Measurement of IgA-RF in RA may prove to be clinically relevant because oithe reported association with disease manifestations, in serum, increased IgA-RF levels were found to be associated wilh progressive joint destruction and in mueosai fluids IgA-RF ieveis ofpatients with RA complicated with Sjogren's syndrome or sicea syndrome (the ocuiar part of Sjogren's syndrome) were reported to be higher than in mucosal fluids of patients with uncompiieated RA [3][4][5][6][7]. It is not known whether in patients with RA the produetion of IgA-RF at mueosai sites is the resuit of a generalized immune reponse or of a local stimulation of the mueosai immune system.…”

Section: Introductionmentioning

confidence: 99%

IgA rheumatoid factor in mucosal fluids and serum of patients with rheumatoid arthritis: immunological aspects and clinical significance

Otten

Daha

Hoogendoorn

et al. 1992

Clinical and Experimental Immunology

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SUMMARYIn order to gain insight into the production and elinical significance of IgA rheumatoid factor (igA-RF) in mueosai fluids ofpatients with rheumatoid arthritis (RA), we examined lear fluid, saliva and serum from 80 patients with RA. Significant correlations were found between lgA-RF levels in tear fluid and saliva (P^OOOl. r^O-57), saliva and serum (P<0-001, r = 0-79). and serum and tear fluid (/*<0-00i, r = 0-3i). No significant eorreiations were found between total IgA levels in these fluids.Comparison between circulating and mucosal IgA-RF levels after eorreetion for total IgA, revealed that mueosai IgA-RF levels are on average 2-5 times higher than circulating IgA-RF leveis. Anaiysis of IgA-RF specificity showed that lacrimal and salivary IgA-RF reactivity with various IgG subclasses is similar and differs from sertim IgA-RF specificity. These results indicate local production of IgA-RF in salivary and iiicrimal glands and support the view ofa common origin of IgA-RF producing B ceils present in mueosai tissues. Mueosai andcireuiating ieveis of IgA and IgA-RF were not associated with tests that quantify tear fluid production. This indieates that mueosai and circulating ieveis of IgA and IgA-RF in patients with RA cannot be regarded as markers for the development of secondary Sjogren's syndrome.

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“…Elevated levels of IgA-RF were found in 44% of patients and correlated with the presence of bone erosions. In a retrospective study of 36 patients with RA (only 13 agglutination assay negative) Arnason et al [9] also found an association between IgA-RF and the occurrence of bone erosions. Teitsson et al [10] demonstrated in a prospective study of 33 patients, 28 of whom developed classical or definite RA, that elevated level of IgA-RF at presentation was associated with the development of bone erosions.…”

Section: Discussionmentioning

confidence: 91%

“…In varying patient groups elevated levels of IgA-RF were associated with the occurrence of bone erosions [9,10] and of extra-articular manifestations [11]. Increased levels of IgG-RF were reported to correlate with disease activity [12].…”

Section: Introductionmentioning

confidence: 99%

Significance of rheumatoid factor isotypes in seronegative rheumatoid arthritis

et al. 1990

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In a cross-sectional study of 124 patients with definite or classical rheumatoid arthritis (RA) and negative agglutination assays, rheumatoid factor (RF) isotypes were measured using an ELISA technique. Elevated levels of IgA-RF were found in 55 patients (44%), IgG-RF in 99 (80%), and IgM-RF in 20 (16%). The levels of IgA- and IgM-RF correlated with each other (P less than 0.001). Elevated levels of IgM-RF were associated with a more severe disease course. Elevated levels of IgA-RF correlated with the occurrence of bone erosions. The results of this study suggest that in patients with RA and negative agglutination assays, both IgM- and IgA-RF are markers of disease severity.

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Relation between bone erosions and rheumatoid factor isotypes.

Cited by 49 publications

References 18 publications

Suppression of rheumatoid factor production by methotrexate in patients with rheumatoid arthritis: Evidence for differential influences of therapy and clinical status on IgM and IgA rheumatoid factor expression

Suppression of rheumatoid factor production by methotrexate in patients with rheumatoid arthritis: Evidence for differential influences of therapy and clinical status on IgM and IgA rheumatoid factor expression

IgA rheumatoid factor in mucosal fluids and serum of patients with rheumatoid arthritis: immunological aspects and clinical significance

Significance of rheumatoid factor isotypes in seronegative rheumatoid arthritis

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