Relation Between Cardiovascular and Metabolic Disease and Cognition in Very Old Age: Cross-Sectional and Longitudinal Findings From the Berlin Aging Study.

Verhaegen, Paul; Borchelt, Markus; Smith, Jacqui

doi:10.1037/0278-6133.22.6.559

Cited by 111 publications

(92 citation statements)

References 45 publications

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“…Two out of the four AP studies did find that AP increased the risk of dementia or possible dementia/mild cognitive impairment [19,24], whereas the other two studies did not find an association [22,23]. For the CHD compound, three studies did not find a relation with cognitive decline or decline to dementia/mild cognitive impairment [22,25,27], whereas one study found that CHD was a significant predictor of vascular dementia [26].…”

Section: Prospective Cohort Studiesmentioning

confidence: 80%

“…For AP, two studies found a significant association with poor cognitive functioning [34,37], whereas one study found no association with mild cognitive impairment [36]. For the CHD compound studies, three studies found a significant association with poor cognitive functioning [27,37,40], one study found no relation with cognitive function or cognitive impairment [38], and one study found a significant association with dementia risk [39].…”

Section: Case-control Studiesmentioning

confidence: 90%

“…Of the six studies investigating MI, four found a significant relation with poor cognitive functioning [27,33,34,37], and two studies found no association with prevalent cognitive impairment [35,36]. For AP, two studies found a significant association with poor cognitive functioning [34,37], whereas one study found no association with mild cognitive impairment [36].…”

Section: Case-control Studiesmentioning

confidence: 99%

“…From the eleven prospective cohort studies, seven focused on MI [16,[18][19][20][21][22][23], four on AP [19,[22][23][24], and four studies on the CHD compound [22,[25][26][27]. Of those focusing on MI, four studies did not find an association with dementia, Alzheimer's disease, vascular dementia or decline to mild cognitive impairment or dementia [20][21][22][23].…”

Section: Prospective Cohort Studiesmentioning

confidence: 99%

“…Out of nine cross-sectional studies, six studies reported on MI [27,[33][34][35][36][37], three on AP [34,36,37], and five on the CHD compound (MI+AP) [27,[37][38][39][40]. Of the six studies investigating MI, four found a significant relation with poor cognitive functioning [27,33,34,37], and two studies found no association with prevalent cognitive impairment [35,36].…”

Section: Case-control Studiesmentioning

confidence: 99%

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[P3–542]: Coronary Heart Disease and Risk for Cognitive Impairment or Dementia: A Systematic Review and Meta‐analysis

Deckers

Schievink

Rodriquez

et al. 2017

Alzheimer's & Dementia

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Aims/HypothesisAccumulating evidence suggests an association between coronary heart disease and risk for cognitive impairment or dementia, but no study has systematically reviewed this association. Therefore, we summarized the available evidence on the association between coronary heart disease and risk for cognitive impairment or dementia. MethodsMedline, Embase, PsycINFO, and CINAHL were searched for all publications until 8 th January 2016. Articles were included if they fulfilled the inclusion criteria: (1) myocardial infarction, angina pectoris or coronary heart disease (combination of both) as predictor variable; (2) cognition, cognitive impairment or dementia as outcome; (3) population-based study; (4) prospective (!1 year follow-up), cross-sectional or case-control study design; (5) !100 participants; and (6) aged !45 years. Reference lists of publications and secondary literature were hand-searched for possible missing articles. Two reviewers independently screened all abstracts and extracted information from potential relevant full-text articles using a standardized data collection form. Study quality was assessed with the Newcastle-Ottawa Scale. We pooled estimates from the most fully adjusted model using random-effects metaanalysis. ResultsWe identified 6,132 abstracts, of which 24 studies were included. A meta-analysis of 10 prospective cohort studies showed that coronary heart disease was associated with increased risk of cognitive impairment or dementia (OR = 1.45, 95%CI = 1.21-1.74, p<0.001). Between-study heterogeneity was low (I 2 = 25.7%, 95%CI = 0-64, p = 0.207). Similar significant associations were found in separate meta-analyses of prospective cohort studies for the individual predictors (myocardial infarction, angina pectoris). In contrast, meta-analyses of cross-sectional and case-control studies were inconclusive. Funding: The author(s) received no specific funding for this work. Competing interests:The authors have declared that no competing interests exist. Conclusion/InterpretationThis meta-analysis suggests that coronary heart disease is prospectively associated with increased odds of developing cognitive impairment or dementia. Given the projected worldwide increase in the number of people affected by coronary heart disease and dementia, insight into causal mechanisms or common pathways underlying the heart-brain connection is needed.

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Section: Prospective Cohort Studiesmentioning

confidence: 80%

Section: Case-control Studiesmentioning

confidence: 90%

Section: Case-control Studiesmentioning

confidence: 99%

Section: Prospective Cohort Studiesmentioning

confidence: 99%

Section: Case-control Studiesmentioning

confidence: 99%

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[P3–542]: Coronary Heart Disease and Risk for Cognitive Impairment or Dementia: A Systematic Review and Meta‐analysis

Deckers

Schievink

Rodriquez

et al. 2017

Alzheimer's & Dementia

View full text Add to dashboard Cite

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Serum neurofilament light chain and cognition decline in US elderly: A cross‐sectional study

Liu,

Chen,

Meng

et al. 2023

Ann Clin Transl Neurol

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ObjectiveEarly identification of cognitive impairment in neurodegenerative diseases like Alzheimer's disease (AD) is crucial. Neurofilament, a potential biomarker for neurological disorders, has gained attention. Our study aims to investigate the relationship between serum neurofilament light (sNfL) levels and cognitive function in elderly individuals in the United States.MethodsThis cross‐sectional study analyzed data from participants aged 60 and above in the National Health and Nutrition Examination Survey (2013–2014). We collected sNfL levels, cognitive function tests, sociodemographic characteristics, comorbidities, and other variables. Weighted multiple linear regression models examined the relationship between ln(sNfL) and cognitive scores. Restricted cubic spline (RCS) visualization explored nonlinear relationships. The stratified analysis examined subgroups' ln(sNfL) and cognitive function association.ResultsThe study included 446 participants (47.73% male). Participants with ln(sNfL) levels between 2.58 and 2.81 pg/mL (second quintile) performed relatively well in cognitive tests. After adjusting for multiple factors, ln(sNfL) levels were negatively correlated with cognitive function, with adjusted β (95% CI) as follows: immediate recall test (IRT): −0.763 (−1.301 to −0.224), delayed recall test (DRT): −0.308 (−0.576 to −0.04), animal fluency test (AFT): −1.616 (−2.639 to −0.594), and digit symbol substitution test (DSST): −2.790 (−4.369 to −1.21). RCS curves showed nonlinear relationships between ln(sNfL) and DRT, AFT, with inflection points around 2.7 pg/mL. The stratified analysis revealed a negative correlation between ln(sNfL) and cognition in specific subgroups with distinct features, with an interaction between diabetes and ln(sNfL).InterpretationHigher sNfL levels are associated with poorer cognitive function in the elderly population of the United States. sNfL shows promise as a potential biomarker for early identification of cognitive decline.

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Associations between coronary heart disease and risk of cognitive impairment: A meta‐analysis

2021

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Background Several studies have demonstrated that coronary heart disease (CHD) is a high risk factor for cognitive impairment, whereas other studies showed that there was no association between cognitive impairment and CHD. The relationship between CHD and cognitive impairment is still unclear based on these conflicting results. Thus, it is of importance to evaluate the association between CHD and cognitive impairment. The present study made a meta‐analysis to explore the association between CHD and risk of cognitive impairment. Methods Articles exploring the association between CHD and cognitive impairment and published before November 2020 were searched in the following databases: PubMed, Web of Science, Medline, EMBASE, and Google Scholar. We used STATA 12.0 software to compute the relative risks (RRs), odds ratios (ORs), or hazard ratios (HRs) and 95% confidence intervals (CIs). Results The meta‐analysis showed a positive association between CHD and risk of all‐cause cognitive impairment with a random effects model (RR = 1.27, 95% CI 1.18 to 1.36, I2 = 82.8%, p < .001). Additionally, the study showed a positive association between myocardial infraction (MI) and risk of all‐cause cognitive impairment with a random effects model (RR = 1.49, 95% CI 1.20 to 1.84, I2 = 76.0%, p < .001). However, no significant association was detected between angina pectoris (AP) and risk of all‐cause cognitive impairment with a random effects model (RR = 1.23, 95% CI 0.95 to 1.58, I2 = 79.1%, p < .001). Subgroup studies also showed that CHD patients are at higher risk for vascular dementia (VD), but not Alzheimer's disease (AD) (VD: RR = 1.34, 95% CI: 1.28–1.39; AD: RR = 0.99, 95% CI: 0.92–1.07). Conclusion In a word, CHD was significantly associated with an increased risk of developing cognitive impairment.

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Relation Between Cardiovascular and Metabolic Disease and Cognition in Very Old Age: Cross-Sectional and Longitudinal Findings From the Berlin Aging Study.

Cited by 111 publications

References 45 publications

[P3–542]: Coronary Heart Disease and Risk for Cognitive Impairment or Dementia: A Systematic Review and Meta‐analysis

[P3–542]: Coronary Heart Disease and Risk for Cognitive Impairment or Dementia: A Systematic Review and Meta‐analysis

Serum neurofilament light chain and cognition decline in US elderly: A cross‐sectional study

Associations between coronary heart disease and risk of cognitive impairment: A meta‐analysis

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