Relation Between Circulating Vitamin K1 and Osteoporosis in the Lumbar Spine in Syrian Post-Menopausal Women

Jaghsi, Sawsan; Hammoud, Taghrid; Haddad, Shaden

doi:10.2174/1874312901812010001

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…Diagnostic sensitivity and specificity of vitamin k1 for osteoporosis were 90 and 98%, respectively (cutoff value: 0.853 ng/ml). The area under the ROC curve (AUC) value for vitamin k1 was 0.984; the odd ratio result was 18.66 [50]. The same result was reported also by Heiss et al [51].…”

Section: Studies On Vitamin K and The Bonesupporting

confidence: 76%

Relation between Vitamin K and Osteoporosis

Jaghsi¹

2021

Clinical Implementation of Bone Regeneration and Maintenance

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Vitamin K is an essential fat-soluble vitamin. The role of vitamin K as a cofactor involved in blood coagulation is well demonstrated. In the past two decades, vitamin K has been receiving more attention due to its role in bone health and metabolism. Vitamin K plays a role in activation of vitamin K-dependent proteins, which are involved not only in blood coagulation but in bone metabolism and the inhibition of arterial calcification. Numerous studies have exhibited the importance of vitamin K in bone health. The bone mineral density (BMD) does not remain steady with age, particularly declining after menopause. Osteoporosis is a metabolic bone disease of reduced bone density, fragile bone, and elevated susceptibility to fracture. A greater understanding of the biological linkages between vitamin K and bone may conduce to new treatment for osteoporosis that may improve bone density and prevent the adverse outcomes of osteoporosis.

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Section: Studies On Vitamin K and The Bonesupporting

confidence: 76%

Relation between Vitamin K and Osteoporosis

Jaghsi¹

2021

Clinical Implementation of Bone Regeneration and Maintenance

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“…OCs play an important role in bone remodeling to maintain bone health. Bone mineral density (BMD) loss and osteoporosis are caused by exceeding osteoclastic bone resorption without a parallel quantity of bone formation by osteoblasts (23). At present, the drug treatments for osteoporosis, including estrogens, bisphosphonates, and selective estrogen‐receptor modulators, target OC‐mediated bone resorption, chiefly retarding BMD loss and thereby decreasing the risk of bone fractures (22, 24).…”

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confidence: 99%

Activation of ROS/MAPKs/NF‐κB/NLRP3 and inhibition of efferocytosis in osteoclast‐mediated diabetic osteoporosis

et al. 2019

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Diabetes mellitus (DM) affects bone metabolism and leads to osteoporosis; however, its pathogenetic mechanisms remain unknown. We found that high glucose (HG) conditions induced the production of reactive oxygen species (ROS) and the expression of proteins related to MAPKs [phosphorylated (p)‐ERK, p‐JNK, and p‐p38], NF‐κB(NF‐κB, p‐IαB, and IKK), and NACHT‐LRR‐PYD domains‐containing protein 3 (NALP3) (NLRP3) [apoptosis‐associated speck‐like protein containing a caspase activation and recruitment domain (ASC), caspase‐1, IL‐18, IL‐1β, and NLRP3] in osteoclasts (OCs) in vitro. Further analysis showed that in HG‐induced OCs, ROS is an upstream signal for MAPKs, NF‐κB, and the NLRP3 inflammasome. Moreover, MAPKs mediated the activation of NF‐κB and NLRP3, whereas NF‐κB up‐regulated the NLRP3 inflammasome response. Interestingly, HG inducement enhanced the bone resorption of OCs but inhibited their efferocytosis, whereas insulin and lipoxin A4 (4) treatment reversed this phenomenon. In streptozotocin‐induced diabetic rats in vivo, the numbers and the bone‐resorption capacity of OCs as well as the serum levels of TRACP‐5b were significantly increased, and the expression of MAPK‐, NF‐κB‐, and NLRP3 inflammasome‐related proteins in the proximal tibia were also significantly elevated; however, treatment with insulin and LXA4 reversed this elevation. Together, these results demonstrated that the activation of ROS/MAPKs/NF‐κB/NLRP3 and the inhibition of efferocytosis in OCs are the main causes of osteoporosis in DM.—An, Y., Zhang, H., Wang, C., Jiao, F., Xu, H., Wang, X., Luan, W., Ma, F., Ni, L., Tang, X., Liu, M., Guo, W., Yu, L. Activation of ROS/MAPKs/NF‐κB/NLRP3 and inhibition of efferocytosis in osteoclast‐mediated diabetic osteoporosis. FASEB J. 33, 12515–12527 (2019). http://www.fasebj.org

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“…us, this study highlights the importance of adjusting results for variables such as estrogen status. Finally, in a small study performed by Jaghsi et al [33] in postmenopausal women without estrogen replacement therapy, serum K1 was positively correlated with lumbar spine BMD. Diagnostic sensitivity and specificity of vitamin K1 values for osteoporosis was 90% and 98%, respectively, and the authors propose that serum vitamin K1 might be of value as a diagnostic tool in osteoporosis.…”

Section: Vitamin K Bone Mineral Density (Bmd) and Fracturesmentioning

confidence: 82%

Vitamin K and Bone Health: A Review on the Effects of Vitamin K Deficiency and Supplementation and the Effect of Non-Vitamin K Antagonist Oral Anticoagulants on Different Bone Parameters

Rodríguez

Curiel

2019

Journal of Osteoporosis

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Although known for its importance in the coagulation cascade, vitamin K has other functions. It is an essential vitamin for bone health, taking part in the carboxylation of many bone-related proteins, regulating genetic transcription of osteoblastic markers, and regulating bone reabsorption. Vitamin K deficiency is not uncommon, as deposits are scarce and dependent upon dietary supplementation and absorption. Vitamin K antagonist oral anticoagulants, which are prescribed to many patients, also induce vitamin K deficiency. Most studies find that low serum K1 concentrations, high levels of undercarboxylated osteocalcin (ucOC), and low dietary intake of both K1 and K2 are associated with a higher risk of fracture and lower BMD. Studies exploring the relationship between vitamin K supplementation and fracture risk also find that the risk of fracture is reduced with supplements, but high quality studies designed to evaluate fracture as its primary endpoint are needed. The reduction in risk of fracture with the use of non-vitamin K antagonist oral anticoagulants instead of warfarin is also of interest although once again, the available evidence offers disparate results. The scarce and limited evidence, including low quality studies reaching disparate conclusions, makes it impossible to extract solid conclusions on this topic, especially concerning the use of vitamin K supplements.

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Relation Between Circulating Vitamin K1 and Osteoporosis in the Lumbar Spine in Syrian Post-Menopausal Women

Cited by 8 publications

References 25 publications

Relation between Vitamin K and Osteoporosis

Relation between Vitamin K and Osteoporosis

Activation of ROS/MAPKs/NF‐κB/NLRP3 and inhibition of efferocytosis in osteoclast‐mediated diabetic osteoporosis

Vitamin K and Bone Health: A Review on the Effects of Vitamin K Deficiency and Supplementation and the Effect of Non-Vitamin K Antagonist Oral Anticoagulants on Different Bone Parameters

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