Relation between clinical risk factors, early cortical changes, and neurodevelopmental outcome in preterm infants

Kersbergen, Karina J.; Leroy, F.; Išgum, Ivana; Groenendaal, Floris; Vries, Linda S. de; Claessens, Nathalie H.P.; Haastert, Ingrid C. van; Moeskops, Pim; Fischer, Clara; Mangin, Jean François; Viergever, Max A.; Dubois, Jessica; Benders, Manon J. N. L.

doi:10.1016/j.neuroimage.2016.07.010

Cited by 67 publications

(54 citation statements)

References 53 publications

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“…This is consistent with a previous observation that elevated cytokines and CD45RO + T lymphocytes in umbilical cord blood are associated with overt cerebral lesions on MRI very soon after birth38. MRI acquisition in the early post-partum period after very preterm birth (around 30 weeks gestational age) is feasible and recent advances in post-processing techniques enable the evaluation of diffuse white matter injury, connectivity measures, cortical maturation and growth trajectories at this early stage394041424344. These approaches could be combined with collateral biological information about fetal/maternal inflammation to investigate specific antenatal determinants of abnormal brain development.…”

Section: Discussionsupporting

confidence: 90%

Association between preterm brain injury and exposure to chorioamnionitis during fetal life

Anblagan

Pataky

Evans

et al. 2016

Sci Rep

102

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Preterm infants are susceptible to inflammation-induced white matter injury but the exposures that lead to this are uncertain. Histologic chorioamnionitis (HCA) reflects intrauterine inflammation, can trigger a fetal inflammatory response, and is closely associated with premature birth. In a cohort of 90 preterm infants with detailed placental histology and neonatal brain magnetic resonance imaging (MRI) data at term equivalent age, we used Tract-based Spatial Statistics (TBSS) to perform voxel-wise statistical comparison of fractional anisotropy (FA) data and computational morphometry analysis to compute the volumes of whole brain, tissue compartments and cerebrospinal fluid, to test the hypothesis that HCA is an independent antenatal risk factor for preterm brain injury. Twenty-six (29%) infants had HCA and this was associated with decreased FA in the genu, cingulum cingulate gyri, centrum semiovale, inferior longitudinal fasciculi, limbs of the internal capsule, external capsule and cerebellum (p < 0.05, corrected), independent of degree of prematurity, bronchopulmonary dysplasia and postnatal sepsis. This suggests that diffuse white matter injury begins in utero for a significant proportion of preterm infants, which focuses attention on the development of methods for detecting fetuses and placentas at risk as a means of reducing preterm brain injury.

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Section: Discussionsupporting

confidence: 90%

Association between preterm brain injury and exposure to chorioamnionitis during fetal life

Anblagan

Pataky

Evans

et al. 2016

Sci Rep

102

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“…Given this obstacle to directly compare folding patterns before and after birth, early ex utero imaging of preterm newborns seems to be the only straightforward strategy to allow a continuous description of folding progression before and after term age. Studies on premature newborns have confirmed the dramatic folding increase during the pre-term period (Dubois, et al 2008b;Kapellou, et al 2006;Kersbergen, et al 2016;Kim, et al 2016a;Makropoulos, et al 2015;Rodriguez-Carranza, et al 2008).…”

Section: Introductionmentioning

confidence: 91%

The dynamics of cortical folding waves and prematurity-related deviations revealed by spatial and spectral analysis of gyrification

et al. 2019

Self Cite

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In the human brain, the appearance of cortical sulci is a complex process that takes place mostly during the second half of pregnancy, with a relatively stable temporal sequence across individuals. Since deviant gyrification patterns have been observed in many neurodevelopmental disorders, mapping cortical development in vivo from the early stages on is an essential step to uncover new markers for diagnosis or prognosis. Recently this has been made possible by MRI combined with post-processing tools, but the reported results are still fragmented. Here we aimed to characterize the typical folding progression ex utero from the pre- to the post-term period, by considering 58 healthy preterm and full-term newborns and infants imaged between 27 and 62 weeks of post-menstrual age. Using a method of spectral analysis of gyrification (SPANGY), we detailed the spatial-frequency structure of cortical patterns in a quantitative way. The modeling of developmental trajectories revealed three successive waves that might correspond to primary, secondary and tertiary folding. Some deviations were further detected in 10 premature infants without apparent neurological impairment and imaged at term equivalent age, suggesting that our approach is sensitive enough to highlight the subtle impact of preterm birth and extra-uterine life on folding.

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“…Studies in infants born preterm have highlighted the importance of optimal structural volumetric brain growth, with larger white matter and cerebellum being particularly related to better cognition and processing speed at pre‐school age. Impairments in cortical folding at term age are associated with subsequent alterations in cognitive, motor, and language outcome in ex‐preterm infants . It is reasonable to hypothesize that neonatal brain volumes are associated with long‐term outcome in CHD; however, large cohort studies testing this hypothesis are lacking.…”

Section: Macrostructural Brain Development In Fetuses and Infants Witmentioning

confidence: 99%

Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease

Claessens

Kelly

Counsell

2017

Develop Med Child Neuro

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This review integrates data on brain dysmaturation and acquired brain injury using fetal and neonatal magnetic resonance imaging (MRI), including the contribution of cardiovascular physiology to differences in brain development, and the relationship between brain abnormalities and subsequent neurological impairments in infants with congenital heart disease (CHD). The antenatal and neonatal period are critical for optimal brain development; the developing brain is particularly vulnerable to haemodynamic disturbances during this time. Altered cerebral perfusion and decreased cerebral oxygen delivery in the antenatal period can affect functional and structural brain development, while postnatal haemodynamic fluctuations may cause additional injury. In critical CHD, brain dysmaturation and acquired brain injury result from a combination of underlying cardiovascular pathology and surgery performed in the neonatal period. MRI findings in infants with CHD can be used to evaluate potential clinical risk factors for brain abnormalities, and aid prediction of functional outcomes at an early stage. In addition, information on timing of brain dysmaturation and acquired brain injury in CHD has the potential to be used when developing strategies to optimize neurodevelopment.

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Relation between clinical risk factors, early cortical changes, and neurodevelopmental outcome in preterm infants

Cited by 67 publications

References 53 publications

Association between preterm brain injury and exposure to chorioamnionitis during fetal life

Association between preterm brain injury and exposure to chorioamnionitis during fetal life

The dynamics of cortical folding waves and prematurity-related deviations revealed by spatial and spectral analysis of gyrification

Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease

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