Relation Between Fructose Content of Semen and Fertility in Man

Abstract

Biochemical and morphological examinations on human semen have been carried out on more than 2000 patients at a fertility clinic, and the findings are reported in this paper. The fructolysis of human semen depends on the presence of normal spermatozoa; centrifuged cell-free seminal plasma shows no fructolysis. The relationship between fructose content and the sperm count of the semen has been investigated. It was found that the absolute fructose concentration was inversely proportional to the number of spermatozoa. The normal fructose value was found to be 1200 to 4500 ug/ml; values below 1200 Mg/ml were considered to be pathological and due to inflammation of the seminal vesicles or to androgen deficiency. The variation in fructose content in a normal patient (1200 to 4500 µg/ml) was never found to be below 1200 pg/ml. The fructose concentration was diminished following abstinence of 8 to 14 days or more. The average fructose value is higher in groups of young patients than in groups of aged patients. Particular attention was given to the group of patients with 'normospermia with postpubescent interstitial-cell in¬ sufficiency' in this investigation. These patients are infertile but after treatment with methyltestosterone or chorionic gonadotrophin the fructose value returned to normal and the patients became fertile.

Spermatozoa Motility and Fructolysis - Comparative Study of Samples Obtained by Masturbation and with Plastic Collectors

“…The significant descent of spermatozoa motility observed in relation to basal codes after 4 hs incubation at room temperature coincides with finding already reported by Freund -1962 andSchirren -1962. Therefore the pattern chosen for this experience, is the determination of spermatozoa motility, as well as the detection of fructose consumption at different hours.…”

Männliche Sterilitätsfaktoren

“…Folgende biochemische Marker sind f/Jr die andrologische Routinediagnostik von Interesse: Fruktose f/Jr das B1/ischendr/isensekret [28,36], saure Phosphatase bzw. Zitronens/iure f/Jr das Prostatasekret [44] und Carnitin f/Jr das Nebenhodensekret [45].…”

Experimentelle Untersuchungen zur Fruktolyse im Samen des Menschen

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[2,3,20,21,22,25,26,27,30] bestätigten seine Beobachtungen. Sie fanden eine erhebliche Fruk tolyse bei Normospermie und eine erheblich geringere bei Hypo-und Oligospermie.

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“…In zellfreien Ejakulaten, bei Aspermie, blieb der F rucht zuckerspiegel unverändert. Mann [18,19], Schirren [25,26] Testreihe 2. Die Ergebnisse dieser Untersuchungsreihe, in der so wohl das Subslratangebot (Fruchtzuckerlösungen in Konzentrationen von 1000 bis 11000 10~6 g/ml) als auch die Enzymmengen (jeweils 0,3, 0,2 und 0,1 ml des gleichen Ejakulates) variiert wurden, sind in Tabelle III wiedergegeben.…”