Relation between Handgrip Strength and Quality of Life in Patients with Arthritis in Korea: The Korea National Health and Nutrition Examination Survey, 2015–2018

Chang, Sea‐Jin; Han, Byoungduck; Park, Hyojin; Kang, Seok

doi:10.3390/medicina58020172

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…As expected, a clear distinction was observed between the subgroups, reflecting the functional muscle strength status of the two categories. Indeed, the pathological group showed low MVC compared with the higher MVC values that typically characterize normal muscle strength [21][22][23] . The strength of the correlation between the two methods was found to be slightly lower in the pathological subjects (r=0.83) than in their healthy counterparts (r=0.90), a difference that may be explained by a greater dispersion of data points presumably due to the patients' clinical histories and clinical factors.…”

Section: Discussionmentioning

confidence: 94%

Radiofrequency Echographic Multi Spectrometry (REMS) for the assessment of muscle strength

Pisani,

Natale,

Lombardi

et al. 2023

International Journal of Bone Fragility

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Objective: Due to the limitations of available methods for muscle strength evaluation, there is a need to develop more effective ways to quantify muscle function and performance in individuals suffering from musculoskeletal diseases. This study investigated the relationship between handgrip strength and a novel parameter derived from ultrasound scans of the forearm obtained using Radiofrequency Echographic Multi Spectrometry (REMS) technology. Estimations of muscle strength were performed in two study groups: healthy subjects and individuals affected by sarcopenia. Methods: A total of 58 Caucasian volunteers (30 healthy individuals and 28 subjects affected by sarcopenia) were recruited. A handgrip strength test was used to measure the Maximum Voluntary Contraction (MVC) of each subject’s dominant arm. Transversal echographic scans of the forearm were performed using an EchoStation device (Echolight S.p.a., Lecce, Italy) equipped with a 40 mm linear probe. A dedicated segmentation algorithm was designed and optimized for automatic identification of the ulnar and radius muscle profiles. The correlation between MVC values and REMS-based estimations of MVC (MVCREMS) was established using a linear regression approach. Results: MVCREMS showed excellent correlation with the MVC taken as ground truth. A high correlation value (r=0.95) was found in the overall population, and the corresponding values in the healthy and pathological subgroups were r=0.90 and r=0.83, respectively (p<0.0001). Conclusion: This technique allows reliable estimation of muscle strength in both pathological and healthy subjects, and is a valid alternative to conventional handgrip tests for use in primary care. In the future, this technique might help to enhance the assessment, screening and prevention of musculoskeletal diseases.

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Section: Discussionmentioning

confidence: 94%

Radiofrequency Echographic Multi Spectrometry (REMS) for the assessment of muscle strength

Pisani,

Natale,

Lombardi

et al. 2023

International Journal of Bone Fragility

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“…Andrews J S et al found in a European population that for every 1 standard deviation decrease in grip strength, the risk of KOA increases by 1.2 times [ 15 ]. Similarly, decreased grip strength has been found to be strongly associated with the development of osteoarthritis in East Asian populations [ 51 ]. Studies on the grip strength of elderly people have also shown that the grip strength of elderly people is positively correlated with the strength of other muscles in the whole body [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between sarcopenia with osteoarthritis and the mediating role of obesity: a univariate, multivariate, two-step Mendelian randomization study

Jin,

Wang,

Jin

et al. 2024

BMC Geriatr

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Background Recent genetic evidence supports a causal role for sarcopenia in osteoarthritis, which may be mediated by the occurrence of obesity or changes in circulating inflammatory protein levels. Here, we leveraged publicly available genome-wide association study data to investigate the intrinsic causal relationship between sarcopenia, obesity, circulating inflammatory protein levels, and osteoarthritis. Methods In this study, we used Mendelian randomization analyses to explore the causal relationship between sarcopenia phenotypes (Appendicular lean mass [ALM], Low hand-grip strength [LHG], and usual walking pace [UWP]) and osteoarthritis (Knee osteoarthritis [KOA], and Hip osteoarthritis [HOA]). Univariable Mendelian randomization (UVMR) analyses were performed using the inverse variance weighted (IVW) method, MR-Egger, weighted median method, simple mode, and weighted mode, with the IVW method being the primary analytical technique. Subsequently, the independent causal effects of sarcopenia phenotype on osteoarthritis were investigated using multivariate Mendelian randomization (MVMR) analysis. To further explore the mechanisms involved, obesity and circulating inflammatory proteins were introduced as the mediator variables, and a two-step Mendelian randomization analysis was used to explore the mediating effects of obesity and circulating inflammatory proteins between ALM and KOA as well as the mediating proportions. Results UVMR analysis showed a causal relationship between ALM, LHG, UWP and KOA [(OR = 1.151, 95% CI: 1.087–1.218, P = 1.19 × 10–6, PFDR = 7.14 × 10–6) (OR = 1.215, 95% CI: 1.004–1.470; P = 0.046, PFDR = 0.055) (OR = 0.503, 95% CI: 0.292–0.867; P = 0.013, PFDR = 0.027)], and a causal relationship between ALM, UWP and HOA [(OR = 1.181, 95% CI: 1.103–1.265, P = 2.05 × 10–6, PFDR = 6.15 × 10–6) (OR = 0.438, 95% CI: 0.226–0.849, P = 0.014, PFDR = 0.022)]. In the MVMR analyses adjusting for confounders (body mass index, insomnia, sedentary behavior, and bone density), causal relationships were observed between ALM, LHG, UWP and KOA [(ALM: OR = 1.323, 95%CI: 1.224- 1.431, P = 2.07 × 10–12), (LHG: OR = 1.161, 95%CI: 1.044- 1.292, P = 0.006), (UWP: OR = 0.511, 95%CI: 0.290- 0.899, P = 0.020)], and between ALM and HOA (ALM: OR = 1.245, 95%CI: 1.149- 1.348, P = 7.65 × 10–8). In a two-step MR analysis, obesity was identified to play a potential mediating role in ALM and KOA (proportion mediated: 5.9%). Conclusions The results of this study suggest that decreased appendicular lean mass, grip strength, and walking speed increase the risk of KOA and decreased appendicular lean mass increases the risk of HOA in patients with sarcopenia in a European population. Obesity plays a mediator role in the occurrence of KOA due to appendicular lean body mass reduction.

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“…Hart [26] showed that handgrip strength was positively and independently related to HRQoL in a subgroup of physically inactive individuals who participated in the 2013-2014 National Health and Nutrition Examination Survey. In Korea, handgrip strength was also positively related to HRQoL of patients with chronic diseases [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

“…Handgrip strength, which is a convenient measure of maximum voluntary muscle strength, has prognostic value for many geriatric syndromes, including multimorbidity, cognitive impairments, impaired mobility, decreased functional capacity, and HRQoL [8]. Additionally, the association between handgrip strength and HRQoL has been reported in post-menopausal women [9], patients with arthritis [10], and cancer survivors [11].…”

Section: Introductionmentioning

confidence: 99%

Multimorbidity and Health-Related Quality of Life in Korean Older Adults: A Mediation Analysis on Handgrip Strength

Kim¹,

Lee²,

Hong³

et al. 2022

JOMH

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Background:The influence of handgrip strength on the relationship of multimorbidity with health-related quality of life (HRQoL) is unknown in geriatric populations. The current study investigated whether or not handgrip strength mediates the association between multimorbidity and HRQoL in a representative sample of Korean adults (3139 men/3753 women) aged 65 years and older. Methods: The data obtained from the 2014-2019 Korea National Health and Nutrition Examination Survey (KNHNES) were used in the current study. The EuroQoL group was used to assess HRQoL. Multimorbidity was defined as co-existence of more than one of the 26 diagnosed diseases specified in the KNHNES. A digital hand dynamometer was used to measure handgrip strength. The covariates included in this study were age, gender, parameters of body fatness, socio-demographics, and parameters of health behaviors. Results: Analysis of variance showed that HRQoL was inversely associated with number of chronic conditions and positively with relative handgrip strength. Particularly, a mediation analysis using the PROCESS macro in SPSS-PC showed that relative handgrip strength partially mediates the influence of multimorbidity on HRQoL. Bootstrapping showed that the indirect effect of comorbidity on HRQoL via relative handgrip strength was significant (p < 0.001) even after adjustments for all the covariates, explaining 8.1% the total effect. Conclusions: The findings of the study emphasize the importance of health-related physical fitness while managing and/or treating multiple chronic conditions for better HRQoL in geriatric populations.

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Relation between Handgrip Strength and Quality of Life in Patients with Arthritis in Korea: The Korea National Health and Nutrition Examination Survey, 2015–2018

Cited by 6 publications

References 27 publications

Radiofrequency Echographic Multi Spectrometry (REMS) for the assessment of muscle strength

Radiofrequency Echographic Multi Spectrometry (REMS) for the assessment of muscle strength

Causal relationship between sarcopenia with osteoarthritis and the mediating role of obesity: a univariate, multivariate, two-step Mendelian randomization study

Multimorbidity and Health-Related Quality of Life in Korean Older Adults: A Mediation Analysis on Handgrip Strength

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