Relation between inflammatory bowel disease, depression, and inpatient outcomes in the United States

Ali, Hassam; Pamarthy, Rahul; Bolick, Nicole Leigh; Lambert, Karissa; Naseer, Maliha

doi:10.1080/08998280.2022.2028344

Cited by 14 publications

(17 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a similar study utilizing the KID on pediatric IBD patients, depression was associated with prolonged hospital stay with an odds ratio of 1.5 (1.19–1.90), p <0.01, while no significant association was noted between depression and procedures, imaging or need for surgery during the hospitalizations [ 20 ]. Another recent study evaluating depression in adult patients with both CD and UC also demonstrated similar results with higher length of hospital stay in patients with depression [ 21 ]. In our study, we found similar results that patients with depression and anxiety had 1.2 and 0.95 additional days of mean hospital stay respectively, after adjusting for other demographic factors and disease severity.…”

Section: Discussionmentioning

confidence: 62%

Rising Burden of Psychiatric and Behavioral Disorders and Their Adverse Impact on Health Care Expenditure in Hospitalized Pediatric Patients with Inflammatory Bowel Disease

Thavamani

Khatana

Umapathi

et al. 2023

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

Purpose The incidence and prevalence of inflammatory bowel disease (IBD) are increasing along with an increasing number of patients with comorbid conditions like psychiatric and behavioral disorders, which are independent predictors of quality of life. Methods Non-overlapping years (2003-2016) of National Inpatient Sample and Kids Inpatient Database were analyzed to include all IBD-related hospitalizations of patients less than 21 years of age. Patients were analyzed for a concomitant diagnosis of psychiatric/behavioral disorders and were compared with IBD patients without psychiatric/behavioral disorder diagnoses for outcome variables: IBD severity, length of stay and inflation-adjusted hospitalization charges. Results Total of 161,294 IBD-related hospitalizations were analyzed and the overall prevalence rate of any psychiatric and behavioral disorders was 15.7%. Prevalence rate increased from 11.3% (2003) to 20.6% (2016), p <0.001. Depression, substance use, and anxiety were the predominant psychiatric disorders. Regression analysis showed patients with severe IBD (odds ratio [OR], 1.57; confidence interval [CI], 1.47–1.67; p <0.001) and intermediate IBD (OR, 1.14; CI, 1.10–1.28, p <0.001) had increased risk of associated psychiatric and behavioral disorders than patients with a low severity IBD. Multivariate analysis showed that psychiatric and behavioral disorders had 1.17 (CI, 1.07–1.28; p <0.001) mean additional days of hospitalization and incurred additional $8473 (CI, 7,520–9,425; p <0.001) of mean hospitalization charges, independent of IBD severity. Conclusion Prevalence of psychiatric and behavioral disorders in hospitalized pediatric IBD patients has been significantly increasing over the last two decades, and these disorders were independently associated with prolonged hospital stay, and higher total hospitalization charges.

show abstract

Section: Discussionmentioning

confidence: 62%

Rising Burden of Psychiatric and Behavioral Disorders and Their Adverse Impact on Health Care Expenditure in Hospitalized Pediatric Patients with Inflammatory Bowel Disease

Thavamani

Khatana

Umapathi

et al. 2023

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

show abstract

“…The NIS has been used previously to report inpatient outcomes and to derive predictive scoring models [ 15 - 17 ]. Since the NIS contains de-identified patient data, it was deemed exempt from review as per institutional review board guidelines.…”

Section: Methodsmentioning

confidence: 99%

Simple scoring for acute necrotizing pancreatitis: mortality in acute necrotizing pancreatitis during admission (MANP-A)

Ali

Bolick

Tillmann

2022

aog

Self Cite

View full text Add to dashboard Cite

Background Acute necrotizing pancreatitis (ANP) can result in a significant healthcare burden. The present study aimed to develop a new scoring system to accurately and promptly identify patients with a high likelihood of mortality to determine the need for aggressive measures. Methods We retrospectively analyzed patients diagnosed with ANP using the National Inpatient Sample (NIS). The mortality in ANP during admission (MANP-A) scoring system was derived using multivariate Cox regression analysis and validated using receiver operating characteristic (ROC) curves in a validation cohort. Results A total of 22,980 hospitalizations were identified in the derivation cohort. There was a predominance of males (65%) and white race (73%). Five variables showed significant association with mortality and were selected for developing the MANP-A scoring system: age ≥60 years; acute renal failure/kidney injury; sepsis with shock; vasopressor use; and disseminated intravascular coagulation. The MANP-A score has a maximum of 5 points and the cutoff for predicting mortality was set at 2 points. The area under the curve (AUC) using the ROC curve of the derivation cohort was 0.9195, 95% confidence interval [CI] 0.8838-0.9551 (P<0.001) for 7- and 0.8954, 95%CI 0.8723-0.9185 (P<0.001) for 30-day periods. The AUC of the Validation Cohort was 0.9204, 95%CI 0.8937-0.9469 (P<0.001) for 7- and 0.9059, 95%CI 0.8893-0.9223 (P<0.001) for 30-day periods. Conclusion We propose a simple and objective score for predicting ANP inpatient mortality at 7- and 30-day intervals with high validity.

show abstract

“…The threshold for statistical significance was kept at 0.05, with all P-values being 2-sided. For primary outcomes such as median length of stay (LOS) and median inpatient charges, we utilized weighted hierarchal linear regression models and adjusted for confounding variables, as previously reported [ 5 ]. We used hierarchal Cox regression models for inpatient mortality and adjusted for patient and hospital-level confounders, including discharge disposition, where indicated.…”

Section: Methodsmentioning

confidence: 99%

“…There is a reported higher prevalence of psychological disorders in IBD patients, concurrently associated with greater consumption of substances such as cocaine, cannabis, and opioids [ 5 , 6 ]. Consumption of these substances and alcohol can complicate the management of IBD.…”

Section: Introductionmentioning

confidence: 99%

Substance abuse and inpatient outcomes in inflammatory bowel disease hospitalizations in the United States: a propensity matched analysis

Patel

Ali

Manickam

et al. 2022

aog

View full text Add to dashboard Cite

Background Inflammatory bowel disease (IBD) is a chronic intestinal inflammation resulting in a genetically susceptible population. The present study aimed to look at the effect of substance abuse on IBD hospitalizations in the United States. Methods We identified primary IBD hospitalizations with substance abuse using the National Inpatient Sample database (2016-2019). A matched comparison cohort of IBD hospitalizations without substance abuse was identified by 1:N propensity score matching using the nearest-neighbor method, based on demographics, hospital-level factors, and comorbidities. Results We matched 4437 IBD hospitalizations with a diagnosis of substance abuse to 4528 hospitalizations without abuse. The median age was higher in the substance abuse group than no abuse (44 vs. 38 years, P<0.001). There was a higher prevalence of discharge to care facilities (2.9% vs. 2.2%) and against medical advice (4.9% vs. 1.8%) in the substance abuse group compared to the no abuse (P<0.001). The median length of hospital stays (LOS) (P=0.74) and hospitalization charge did not differ significantly (P=0.57). There was no significant difference in 30-day inpatient mortality among cohorts (adjusted hazard ratio 0.74, 95% confidence interval 0.32-1.81; P=0.54). There was a higher prevalence of psychoses (2.5% vs. 1.3%) and depression (18.8% vs. 15.7%) in IBD hospitalizations with substance abuse compared to those without abuse (P<0.001). Conclusions This study reports no difference in median LOS, hospitalization charge, or mortality risk in IBD hospitalizations based on substance abuse. There is a higher prevalence of psychoses and depression in IBD patients, requiring screening for substance abuse to improve overall outcomes.

show abstract

Relation between inflammatory bowel disease, depression, and inpatient outcomes in the United States

Cited by 14 publications

References 27 publications

Rising Burden of Psychiatric and Behavioral Disorders and Their Adverse Impact on Health Care Expenditure in Hospitalized Pediatric Patients with Inflammatory Bowel Disease

Rising Burden of Psychiatric and Behavioral Disorders and Their Adverse Impact on Health Care Expenditure in Hospitalized Pediatric Patients with Inflammatory Bowel Disease

Simple scoring for acute necrotizing pancreatitis: mortality in acute necrotizing pancreatitis during admission (MANP-A)

Substance abuse and inpatient outcomes in inflammatory bowel disease hospitalizations in the United States: a propensity matched analysis

Contact Info

Product

Resources

About