Relation between morningness–eveningness score and depressive symptoms among patients with delayed sleep phase syndrome

Abe, Takashi; Inoue, Yuichi; Komada, Yoko; Nakamura, Masaki; Asaoka, Shoichi; Kanno, Meri; Shibui, Kayo; Hayashida, Kentaro; Usui, Akira; Takahashi, Keiichi

doi:10.1016/j.sleep.2010.12.017

Cited by 88 publications

(68 citation statements)

References 42 publications

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“…There are natural variations in chronotype at all ages with some showing morning preference and some showing evening preference. Extreme chronotypes are associated with multiple psychiatric disorders (47)(48)(49)(50), and it would be interesting in future studies to determine how molecular rhythms correlate with chronotype. Interestingly, a condition called "sundowning" or "sundown syndrome" affects some 20-40% of older people with dementia or Alzheimer's disease where they become confused, delirious, anxious, and agitated in the evening when the sun goes down, causing them to wander, become combative, and have difficulties sleeping (51).…”

Section: Discussionmentioning

confidence: 99%

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

Chen

Logan

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

238

219

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With aging, significant changes in circadian rhythms occur, including a shift in phase toward a “morning” chronotype and a loss of rhythmicity in circulating hormones. However, the effects of aging on molecular rhythms in the human brain have remained elusive. Here, we used a previously described time-of-death analysis to identify transcripts throughout the genome that have a significant circadian rhythm in expression in the human prefrontal cortex [Brodmann’s area 11 (BA11) and BA47]. Expression levels were determined by microarray analysis in 146 individuals. Rhythmicity in expression was found in ∼10% of detected transcripts (P < 0.05). Using a metaanalysis across the two brain areas, we identified a core set of 235 genes (q < 0.05) with significant circadian rhythms of expression. These 235 genes showed 92% concordance in the phase of expression between the two areas. In addition to the canonical core circadian genes, a number of other genes were found to exhibit rhythmic expression in the brain. Notably, we identified more than 1,000 genes (1,186 in BA11; 1,591 in BA47) that exhibited age-dependent rhythmicity or alterations in rhythmicity patterns with aging. Interestingly, a set of transcripts gained rhythmicity in older individuals, which may represent a compensatory mechanism due to a loss of canonical clock function. Thus, we confirm that rhythmic gene expression can be reliably measured in human brain and identified for the first time (to our knowledge) significant changes in molecular rhythms with aging that may contribute to altered cognition, sleep, and mood in later life.

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Section: Discussionmentioning

confidence: 99%

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

Chen

Logan

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

238

219

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“…15,16,21,27 Under these circumstances, their effort to stay awake during the daytime develops desynchronization-related mental and physical symptoms such as depression, fatigue or headache, possibly leading to lower mental/physical QOL. 37,38 This fact might explain that circadian rhythm-related sleep problems were associated with lower mental and physical QOL especially in visually impaired individuals without LP. Consequently, in visually impaired individuals with LP, the factors associated with lower QOL were similar to the controls except for the cause of visual impairment.…”

Section: Discussionmentioning

confidence: 99%

A Nationwide Cross-Sectional Survey of Sleep-Related Problems in Japanese Visually Impaired Patients: Prevalence and Association with Health-Related Quality of Life

Tamura

Sasai-Sakuma

Morita

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objectives: This questionnaire-based cross-sectional study was conducted (1) to estimate the prevalence of sleep-related problems, and (2) to explore factors associated with lower physical/mental quality of life (QOL), particularly addressing sleep-related problems among Japanese visually impaired people. Methods: This nationwide questionnaire-based survey was administered to visually impaired individuals through the Japan Federation of the Blind. Visually impaired individuals without light perception (LP) (n = 311), those with LP (n = 287), and age-matched and gender-matched controls (n = 615) were eligible for this study. Study questionnaires elicited demographic information, and information about visual impairment status, sleep-related problems, and health-related quality of life. Results: Visually impaired individuals with and without LP showed higher prevalence rates of irregular sleep-wake patterns and difficulty maintaining sleep than controls (34.7% and 29.4% vs. 15.8%, 60.1% and 46.7% vs. 26.8%, respectively; p < 0.001). These sleep-related problems were observed more frequently in visually impaired individuals without LP than in those with LP. Non-restorative sleep or excessive daytime sleepiness was associated with lower mental/physical QOL in visually impaired individuals with LP and in control subjects. However, visually impaired individuals without LP showed irregular sleepwake pattern or difficulty waking up at the desired time, which was associated with lower mental/physical QOL. Conclusions: Sleep-related problems were observed more frequently in visually impaired individuals than in controls. Moreover, the rates of difficulties were higher among subjects without LP. Sleep-related problems, especially circadian rhythm-related ones, can be associated with lower mental/physical QOL in visually impaired individuals without LP. Keywords: circadian rhythm sleep-wake disorder, health-related quality of life, light perception, prevalence, sleep-related problems, visual impairment I NTRO DUCTI O NVisually impaired individuals are likely to have any of several comorbid mental/physical disorders including diabetes mellitus, hypertension, cognitive impairment, and depression/ anxiety. [1][2][3][4][5][6] The severity of these mental/physical disorders is reportedly correlated with visual impairment.1-9 Therefore, those individuals might be at risk for lower health-related quality of life (QOL). 7-10Sleep-related problems have been observed frequently in visually impaired individuals.11-15 Reportedly, especially in people without light perception (LP), inhibited transmission of light signals to the suprachiasmatic nuclei might cause sleeprelated problems because of external desynchronization of the biological clock. 16,17 Indeed, the rate of circadian-related sleepwake disorders is likely to be higher among visually impaired individuals without LP than among those with LP.12 In Japan, no large nationwide study of this subject has ever been reported. The actual prevalence of sleep-related problems amon...

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“…Several earlier studies with relatively small sample sizes have demonstrated that evening types have a greater likelihood for depressive symptoms or major depression compared with other chronotypes (Abe et al, 2011;Antunes et al, 2010;Drennan et al, 1991;Chelminski et al, 1999;GasparBaba et al, 2009;Hasler et al, 2010;Hidalgo et al, 2009;Kim et al, 2010;Kitamura et al, 2010;Levandovski et al, 2011;Meliska et al, 2011;Selvi et al, 2010). Gaspar-Baba and colleagues (2009) have reported that evening types had more severe depressive symptoms, and Selvi and colleagues (2011) found that evening types were also more prone to attempt violent suicides than other chronotypes.…”

Section: Introductionmentioning

confidence: 98%

Evening types are prone to depression

Merikanto

Lahti

Kronholm

et al. 2013

Chronobiology International

210

114

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Certain preferences for the timing of daily activities (chronotype) may predispose an individual to sleep problems and mood disorders. In this study, we have examined the link between chronotypes and depression. Participants (N ¼ 6071) were recruited from a random sample of the general population aged 25 to 74 yrs living in defined geographical areas, as part of the National FINRISK Study in 2007 in Finland. Chronotype assessment was based on six items from the original Horne-Ö stberg Morningness-Eveningness Questionnaire. Depression was assessed with four self-reported items, including two probes for a diagnosis of a major depressive episode, diagnosed or treated depression, and use of antidepressants. We also analyzed correlations between chronotype and several health indicators, such as systolic and diastolic blood pressures, resting heart rate, weight, and waist circumference. The odds ratios for a range of indicators of depression were higher for evening types (2.7-to 4.1-fold) and intermediate types (1.5-to 1.9-fold) than for morning types. Our results suggest that individuals having a preference for evening hours to carry out their daily activities are prone to depression. (Author correspondence: ilona.merikanto@helsinki.fi)

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Relation between morningness–eveningness score and depressive symptoms among patients with delayed sleep phase syndrome

Cited by 88 publications

References 42 publications

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

A Nationwide Cross-Sectional Survey of Sleep-Related Problems in Japanese Visually Impaired Patients: Prevalence and Association with Health-Related Quality of Life

Evening types are prone to depression

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