Relation between myoglobin and cardiac dysfuncion in myocarditis. Immunohistochemical study of endomyocardial biopsy specimens.

Horike, Kiyoshi; Fujiwara, Hisayoshi; Matsuda, Mitsuo; Kawamura, Atsushi; Ishida, Moriharu; Takemura, Genzou; Kida, Mitsugu; Uegaito, Takashi; Tanaka, Masahiro; Matsumori, Akira; Fujiwara, Takako; Kawai, Chuichi

doi:10.1253/jcj.55.24

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…A study in myoglobin-knockout mice suggested that myoglobin plays an important role in oxygen delivery to mitochondria [38]. Horike and colleagues analyzed the degree of myoglobin staining in EMBs of patients with myocarditis using immunohistochemistry and found that myoglobin staining relates to disease severity as well as the duration of acute myocarditis [39]. Their findings are in agreement with our data suggesting higher levels of myoglobin are associated with worse disease.…”

Section: Discussionsupporting

confidence: 90%

“…In summary, our data suggest that serum myoglobin is a valuable screening tool to identify patients with myocarditis and LGE on CMR as it peaks early, reflects acuity due to its short lifespan, and appears to perform more accurately in acute myocarditis than the current laboratory gold standard TnT-hs. The data are biologically plausible, as myoglobin is released during cardiac injury [ 28 , 29 , 45 ] and its expression on EMBs increases with the severity of myocarditis [ 39 ]. Our findings on myoglobin obtained from the human myocarditis cohort reproduced in a clinically relevant mouse model of CVB3 myocarditis.…”

Section: Discussionmentioning

confidence: 99%

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Myoglobin for Detection of High-Risk Patients with Acute Myocarditis

Kottwitz

Bruno

Berg

et al. 2020

J. of Cardiovasc. Trans. Res.

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There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), can be estimated based on routine blood markers. A total of 44 patients were diagnosed with acute myocarditis and included in this study. There was strong correlation between myoglobin and LGE (r s = 0.73 [95% CI 0.51; 0.87], p < 0.001), while correlation was weak between LGE and TnT-hs (r s = 0.37 [95% CI 0.09; 0.61], p = 0.01). Receiver operating curve (ROC) analysis determined myoglobin ≥ 87 μg/L as cutoff to identify myocarditis (92% sensitivity, 80% specificity). The data were reproduced in an established model of coxsackievirus B3 myocarditis in mice (n = 26). These data suggest that myoglobin is an accurate marker of acute myocarditis.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Myoglobin for Detection of High-Risk Patients with Acute Myocarditis

Kottwitz

Bruno

Berg

et al. 2020

J. of Cardiovasc. Trans. Res.

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“…92,93 Concerning myoglobin, one study analysed the degree of myoglobin staining in EMBs of patients with myocarditis using immunohistochemistry and found that myoglobin expression relates to disease severity as well as the duration of acute myocarditis. 94 Since myocarditis typically presents as a systemic illness that may also affect skeletal muscle, it is plausible that more severe acute myocarditis may be associated with the release of myoglobin from skeletal muscle, which could contribute to higher blood levels of the markers. 95,96 Highly elevated cardiac markers and enzymes may help to rule in acute cases, but absence of them does Table 2.…”

Section: Serum Cardiac Markers and Enzymesmentioning

confidence: 99%

Update on myocarditis – what we know so far and where we may be heading

Rroku

Kottwitz

Heidecker

2020

European Heart Journal. Acute Cardiovascular Care

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“…Its use has expanded beyond morphological research to include the biochemical, immunological 6,7 and genetic engineering fields. Indications for the procedure are not limited to patients with cardiomyopathy and specific heart muscle disease.…”

Section: Discussionmentioning

confidence: 99%

National Survey of the Use of Endomyocardial Biopsy in Japan

et al. 1998

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A national survey of endomyocardial biopsy procedures was conducted in Japan. Questionnaires were mailed to 852 institutions and statistical analysis of the 213 completed questionnaires (25.0% of the total) was performed. Cardiac biopsies were being performed at 134 of these institutions (62.9%), representing a 5.5-fold increase over 1980. A total of 19,964 cardiac biopsies have been performed in Japan. Specimens were obtained from the right ventricle at 113 institutions, and from the left ventricle at 76 centers. The Konno-Sakakibara bioptome was used at 32 institutions, whereas the long sheath method was used at 98 institutions. Sixty of the institutions (44.8%) had encountered ventricular wall perforation. The perforation rate of the two ventricles combined was 0.7% (147 of 19,964 cases), with a mortality rate of 0.05% (10 of 19,964 cases). Endomyocardial biopsy has become widespread in Japan, and its safety was ascertained by this national survey. (Jpn Circ J 1998; 62: 909 -912)

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Relation between myoglobin and cardiac dysfuncion in myocarditis. Immunohistochemical study of endomyocardial biopsy specimens.

Cited by 6 publications

References 10 publications

Myoglobin for Detection of High-Risk Patients with Acute Myocarditis

Myoglobin for Detection of High-Risk Patients with Acute Myocarditis

Update on myocarditis – what we know so far and where we may be heading

National Survey of the Use of Endomyocardial Biopsy in Japan

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