Relation Between Personality and Ventilatory Response to Carbon Dioxide in Normal Subjects: A Role in Asthma?

Saunders, N. A.; Heilpern, Sandra; Rěbuck, A. S.

doi:10.1136/bmj.1.5802.719

Cited by 54 publications

(24 citation statements)

References 7 publications

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“…Clark and Cohrane [19] found amongst patients with COPD that those having a lower central venous PC 02 (PvCO,) were more extrovert than those with a PvCO, higher than predicted. Saun ders et al [20] , also using the Eysenck Per sonality Inventory [21], found a significant correlation between extraversión score and ventilatory response to C 02. Intrinsically low CO, responsiveness operating with lung mechanical derangement produces hyper capnia in asthmatic patients [22].…”

Section: Discussionmentioning

confidence: 96%

Respiratory Drive in Patients with Chronic Obstructive Pulmonary Disease

Patakas¹,

Louridas²,

Argyropoulou³

et al. 1978

Respiration

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Respiratory drive (Δp 0.1ΔdPCO₂) and ventilatory response ΔVΕ/Δ PCO₂) to CO₂ has been estimated in 20 normal subjects and 28 patients with chronic obstructive pulmonary disease (COPD). In patients with COPD, drive and ventilatory response to CO₂ were diminished, but no statistical correlation with FEV₁, MBC, TLC, FRC, RV/TLC was found. A statistically negative correlation was found between blood bicarbonate and drive or ventilatory response to CO₂. Patients with emphysema and normal PaCO₂demonstrated normal Δp 0.1/ΔPCO₂. In contrast, patients with chronic bronchitis with the same pulmonary function abnormalities and hypercapnia had significant diminution of the ΔP0.1/ΔPCO₂. Therefore, we feel that pulmonary function abnormalities alone cannot explain the ΔV 0.1/ΔPCO₂ decrease; in most cases there should coexist a diminished respiratory sensitivity.

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Section: Discussionmentioning

confidence: 96%

Respiratory Drive in Patients with Chronic Obstructive Pulmonary Disease

Patakas¹,

Louridas²,

Argyropoulou³

et al. 1978

Respiration

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“…The HVR values among our female subjects exhibited a broader range of variation than those of the men so that perhaps a greater variabil ity among women contributed to the in consistency in previous reports. Lack of control for menstrual cycle phase or use of birth control pills may also have contri buted to conflicting results of HVR and HCVR comparisons in men and women [8,12,14,16]. However, even when tested in the same (follicular) phase, lower [19] as well as higher [I] HVR values have been seen in women.…”

Section: Discussionmentioning

confidence: 99%

Possible Gender Differences in the Effect of Exercise on Hypoxic Ventilatory Response

Regensteiner

Pickett²,

McCullough³

et al. 1988

Respiration

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Gender differences in resting ventilation and hypoxic ventilatory response (HVR) have been reported. Ventilation and HVR are closely related to changes in metabolic rate in men. However, it is unclear whether there is a comparable relationship between metabolic rate and ventilation or HVR in women. We studied 13 men and 12 women to determine whether exercise-induced increases in metabolic rate influenced ventilation, HVR, and hypercapnic ventilatory response (HCVR) differently in men and women. Minute ventilation per unit metabolic rate was higher (lower end-tidal PCO₂) in women than men during rest and mild exercise. Resting HVR values were similar in men and women. With mild, exercise-induced increases in O₂ consumption (24 ± 4% in men and 27 ± 2% in women, p = NS), HVR increased in men (p < 0.05) but not in women. Moderate exercise-induced increases in O₂ consumption (313 ± 13% in men and 330 ± 13% in women, p = NS), raised hypoxic responses in both sexes. HCVR values were similar in men and women at rest and during mild exercise. Moderate exercise increased HCVR equally in the sexes. Thus the higher resting ventilation and lesser change in HVR during mild exercise suggested that women were less sensitive to mild metabolic rate stimulation than men.

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“…All these studies reported males to have a greater slope of the ventilation / PCO2 curve, and all but Saunders et al (1972) also found them to have an increased intercept value. The magnitude of the sex difference varies greatly across studies however.…”

Section: Awake Differencesmentioning

confidence: 96%

Ventilation during sleep onset

Colrain

Trinder

Fraser

et al. 1987

Journal of Applied Physiology

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There is now considerable evidence which indicates that respiratory activity is different during sleep compared with wakefulness. However, there has been little work on respiratory changes during the transitional period from wakefulness to sleep. The present study was concerned with the quantitative and temporal properties of ventilation during sleep onset. Sleep onsets were studied in five young male adults in a series of single-subject designs in which sleep onsets were replications. The results indicated that during sleep onset the loss of alpha-activity in the electroencephalogram was associated with a substantial, rapid, and highly predictable reduction in ventilation. The change in ventilation was typically due to a reduction in tidal volume and was, in part, secondary to a reduction in metabolic rate. We speculate that the nonmetabolic component may reflect the loss of waking neural drive to respiration, though the present study did not eliminate a variety of other interpretations.

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Relation Between Personality and Ventilatory Response to Carbon Dioxide in Normal Subjects: A Role in Asthma?

Cited by 54 publications

References 7 publications

Respiratory Drive in Patients with Chronic Obstructive Pulmonary Disease

Respiratory Drive in Patients with Chronic Obstructive Pulmonary Disease

Possible Gender Differences in the Effect of Exercise on Hypoxic Ventilatory Response

Ventilation during sleep onset

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