Relation Between Postexercise Abnormal Heart Rate Recovery and Myocardial Damage Evidenced by Gated Single-Photon Emission Computed Tomography

Lima, Ricardo; Lorenzo, Andrea De; Soares, Adriana J.

doi:10.1016/j.amjcard.2005.11.078

Cited by 23 publications

(22 citation statements)

References 14 publications

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“…Increased sympathetic neural stimulation due to exercise during TET can induce further coronary constriction, which can lead to myocardial ischemia, particularly in arterial segments narrowed by 70% or more. On the other hand, only a few studies have shown a relationship between myocardial ischemia detected by myocardial SPECT and HRR (15,20). Georgoulias et al (15) reported an HRR sensitivity of 73% and specificity of 76% for detecting myocardial ischemia, with regard to HRR of less than 21 beats with no cool-down period.…”

Section: Discussionmentioning

confidence: 99%

Heart rate recovery may predict the presence of coronary artery disease

Akyüz

Alpsoy²,

Akkoyun³

et al. 2014

Anadolu Kardiyol Derg

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Objective: We investigated whether post-exercise first minute abnormal heart rate recovery (HRR1) helps to predict the presence and severity of CAD, because of some confounding data. Methods: A cross-sectional, retrospective study was performed. Two hundred individuals were included. Gensini scores and the number of coronary artery involvements were used to evaluate the severity of CAD. Student's t-test, Mann-Whitney U test and chi-square test were used for the analysis continuous and categorical data. Spearman's correlation analysis was used to determine whether there is correlation between Gensini scoring and HRR1. Univariate and multivariate logistic regression were used to determine predictors for abnormal HRR1. ROC curve analysis was performed to detect the best sensitivity and specificity value of HRR1 in predicting CAD presence. Results: Seventy subjects (35%) did not have CAD, and CAD was present in 130 patients (65%). HRR1 ≤21 beats with ROC analysis was determined to be the best cut off point. After adjustment between the two groups in terms of age, gender, diabetes, hypertension, dyslipidemia or smoking (all p>0.05), there was relationship CAD presence and abnormal HRR1 (OR=2.1, 95% CI: 1.1-3.9, p=0.02), but not between CAD severity and HRR1 (r=-0.13, p=0.112). The sensitivity, specificity, and the positive and negative predictive values of abnormal HRR1 ≤21 beats at first minute for predicting CAD presence were 76.1%, 41.3% (AUC=0.588, CI 95%: 0.517-0,657, p=0.039), 70.7% and 48.3%, respectively. Conclusion: In the study abnormal HRR1 predicted the presence of CAD, but not the severity of it. (Anadolu Kardiyol Derg 2014; 14: 351-6)

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Section: Discussionmentioning

confidence: 99%

Heart rate recovery may predict the presence of coronary artery disease

Akyüz

Alpsoy²,

Akkoyun³

et al. 2014

Anadolu Kardiyol Derg

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“…In addition, HRR-1 <6.5 bpm has been shown to be a predictor of hospitalisation and death in HF patients (Arena et al 2006). A delayed HRR-1 has been associated with older age (Lima et al 2006), lower exercise capacity (Cole et al 1999;Hirsh et al 2006), lower physical activity (Carnethon et al 2005), and the presence of cardiovascular risk factors, including diabetes (Lind and Andren 2002), hypertension (Polonia et al 2006), obesity (Lind and Andren 2002), and the metabolic syndrome (Sung et al 2006). …”

Section: Heart Rate (Bpm)mentioning

confidence: 97%

Impact of the exercise mode on heart rate recovery after maximal exercise

et al. 2008

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Heart rate recovery 1 min after exercise termination (HRR-1) is a prognostic predictor. However, the influence of the exercise mode on HRR-1 is incompletely characterised. Twenty-nine young and healthy subjects and 16 elderly patients with chronic heart failure underwent cardiopulmonary exercise testing using cycle ergometer and treadmill ramp protocols in random order. HRR-1 and heart rate recovery 2 and 3 min after exercise (HRR-2, HRR-3) during active recovery and peak oxygen consumption (peak VO(2)) were measured. In both healthy subjects (32 +/- 14 vs. 27 +/- 10 bpm) and HF patients (19 +/- 8 vs. 14 +/- 9 bpm), HRR-1 was faster after cycle exercise (p = 0.029; p for between group difference 0.94). In contrast, HRR-2 and HRR-3 were similar after both tests in both groups. Peak VO(2) was lower during cycle as compared to treadmill exercise in both groups. In conclusion, in both healthy subjects and HF patients, HRR-1 depends on the mode of exercise as peak VO(2) does.

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“…SSS and SRS were classified using the following classification system:\4: normal, 4-8: mildly abnormal, 9-13: moderately abnormal, and C14: severely abnormal. 2,9,10 Clinical Follow-Up Follow-up information on patient survival was obtained in all patients by dedicated research personnel. Data were obtained by telephone contact with the patient, with one of his or her immediate relatives and complemented by information obtained by the patient's general physician or patient charts from recurrent hospital admissions.…”

Section: Spect Image Analysis Protocolmentioning

confidence: 99%