Relation between postprandial satiation and antral area in normal subjects

Jones, K.L.; Doran, S.; Hveem, Kristian; Bartholomeusz, F. D.L.; Morley, J. E.; Sun, W. M.; Chatterton, B. E.; Horowitz, Michael

doi:10.1093/ajcn/66.1.127

Cited by 167 publications

(101 citation statements)

References 30 publications

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“…1 An option to prolong satiety and to reduce food intake is by delaying gastric emptying and/or small intestinal transit time. [2][3][4] This may be achieved by activation of the ileal brake. 5 The ileal brake is the primary inhibitory distal-to-proximal feedback mechanism that controls meal transit through the gastrointestinal tract and is thought to regulate and optimize nutrient digestion and absorption.…”

Section: Introductionmentioning

confidence: 99%

Effect of ileal fat perfusion on satiety and hormone release in healthy volunteers

et al. 2008

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Objective: The ileal brake is a feedback mechanism activated by nutrients, especially fat, with marked effects on satiety. The effects of low doses of ileal fat on satiety are largely unknown. We therefore studied the effect of ileal vs oral delivery of low doses of fat on satiety and gut peptide secretion. Design: Randomized, single-blind crossover design. Subjects: Sixteen healthy, normal-weight volunteers (6 male; mean age 26 years, mean body mass index 22.4). Intervention: Participants were intubated with a 290-cm-long nasoileal tube and consumed, on 3 consecutive days, either a liquid breakfast with 3 g fat followed by an ileal placebo infusion at t ¼ 105-150 min (treatment C) or a fat-free liquid breakfast followed by an ileal infusion of either an emulsion of 3 g (treatment I3g) or 9 g (treatment I9g) fat (safflower oil). Measurements: Satiety parameters by visual analog scales and plasma concentrations of CCK and PYY. Results: C significantly increased satiety and CCK secretion compared with the fat-free breakfast. Ileal fat perfusion of both 3 and 9 g (I3g and I9g) significantly increased satiety during and after fat perfusion, without differences in satiety between I3g and I9g. During ileal fat infusion, CCK increased dose dependently, whereas PYY concentrations increased significantly only after 9 g of fat. Secretion of CCK but not of PYY correlated to satiety levels. Conclusion: Postprandial satiety following a liquid breakfast can be effectively and significantly increased by small amounts (as little as 3 g) of fat perfused into the ileum. Ileal fat dose-dependently increased CCK but not PYY secretion. The satiating effect of ileal fat may be partly mediated by CCK.

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Section: Introductionmentioning

confidence: 99%

Effect of ileal fat perfusion on satiety and hormone release in healthy volunteers

et al. 2008

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“…This factor increases during the growth phase but food volume being conditioned by gastric capacity and time-course of feeding means that it can become, under certain conditions, a limiting factor (Jones et al, 1997;Kissilef & van Itallie, 1982).…”

Section: Introductionmentioning

confidence: 99%

Energy density of the diet, food volume and energy intake by age and sex in a healthy population

et al. 1999

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Objective: To assess the changes in energy intake (EI), food intake volume (FV) and energy density (ED) related to age and gender in a population in the Mediterranean area of Spain, and to determine the different role of FV and ED on the consecution of the adequate EI throughout lifespan. Subjects: One thousand and eighty-eight individuals (1 ± 65 y) randomly selected from the population census. Design: Cross-sectional study in which food intake was quanti®ed by 24 h dietary recall, three non-consecutive days. Height and weight measurements were taken in 885 individuals. Results: EI, FV and ED increased progressively (P`0.001) between 1 ± 2 y and 10 ± 12 y of age in both sexes. At 1 ± 2 y the EI is 5.8 AE 1.5 MJad, FV 1195 AE 275 gad and ED 4.8 AE 0.9 kJag. Between 1 ± 2 and 3 ± 4 y, coinciding with an EI that increased up to 7.2 AE 1.5 MJad, there was an increase in ED up to 6.1 AE 0.8 kJag (P`0.001), while the FV did not vary signi®cantly. At the start of puberty, between 7 ± 9 and 10 ± 12 y, when the EI increased to 9.7 AE 0.9 MJad (P`0.001) in males, the ED rose to 7.1 AE 0.9 kJag (P`0.001) while the FV did not vary signi®cantly. At this age, a signi®cant difference between the genders was observed in the EI (P 0.04), and in the ED (P 0.02) but not, as yet, in the FV. During adulthood, a signi®cant trend towards decrease (P`0.001 in both sexes) was observed in EI and ED. However, FV decreased signi®cantly only in females. Conclusions: The changes in energy intake that were observed with respect to age and gender were accommodated-for by changes in the ED of the diet rather than by variations in food volume intake. Autoregulation of the ED of the diet, suf®cient for energy intake requirement changes, appears to be an essential human capacity for ef®cient nutrition. Sponsorship: This study was funded, in part, by a grant for B Vizmanos from DANONE, Spain.

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“…If air is present, the ultrasonographer can apply gentle pressure with the transducer to move the air away from the area being scanned (Tarjan et al, 2000). Additionally, it is important to minimise respiration effects when scanning, and this can be achieved by taking images at a constant point throughout the respiration cycle, or by asking patients to hold their breath as images are acquired (Jones et al, 1997).…”

Section: Scanning Techniquesmentioning

confidence: 99%