Relation between Presynaptic and Postsynaptic Dopaminergic Functions Measured by Positron Emission Tomography: Implication of Dopaminergic Tone

Ito, Hiroshi; Kodaka, Fumitoshi; Takahashi, Hidehiko; Takano, Harumasa; Arakawa, Ryosuke; Shimada, Hitoshi; Suhara, Tetsuya

doi:10.1523/jneurosci.6024-10.2011

Cited by 48 publications

(46 citation statements)

References 43 publications

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“…Stimulation of striatal D 2 receptors by dopamine likely suppresses inhibitory control by the frontostriatal circuits over impulsive responding (23). Assuming an inverse correlation between D 2 receptor availability and presynaptic dopamine release (16), this would be in agreement with our finding on the positive association of striatal D 2 receptor availability with the fronto-striatal FC. Keep in mind that D 2 receptor availability is also influenced by receptor density.…”

Section: Discussionsupporting

confidence: 90%

“…Individual differences in striatal D 2 receptor availability have been associated with personality, mood, and psychiatric symptoms. Healthy subjects with lower D 2 receptor availability, presumably due to higher presynaptic dopamine release (16), in the dorsal, but not ventral, striatum had a propensity to rate themselves as highly socially desirable (17). Self-reported social desirability is negatively associated with subjective hopelessness (18), as measured by the Beck Hopelessness Scale (BHS) (19), an index of feelings about the future, expectations, and loss of motivation.…”

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confidence: 99%

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Superiority illusion arises from resting-state brain networks modulated by dopamine

Yamada

Uddin

Takahashi³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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The majority of individuals evaluate themselves as superior to average. This is a cognitive bias known as the "superiority illusion." This illusion helps us to have hope for the future and is deep-rooted in the process of human evolution. In this study, we examined the default states of neural and molecular systems that generate this illusion, using resting-state functional MRI and PET. Resting-state functional connectivity between the frontal cortex and striatum regulated by inhibitory dopaminergic neurotransmission determines individual levels of the superiority illusion. Our findings help elucidate how this key aspect of the human mind is biologically determined, and identify potential molecular and neural targets for treatment for depressive realism.positive illusion | dorsal anterior cingulate cortex | sensorimotor striatum | behavioral control | hopelessness

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

Superiority illusion arises from resting-state brain networks modulated by dopamine

Yamada

Uddin

Takahashi³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…The relationship between pre and postsynaptic markers for the DA system is poorly understood and to date only one study has investigated the relationship between DA synthesis capacity and D 2/3 receptor levels in vivo in man, reporting a negative correlation. 61 The available observations may be interpreted as a relatively higher degree of environmental influence on DA synthesis capacity, which may thus be a more state-related marker. This is corroborated by the observation of changes in [ 18 F] DOPA uptake in high-risk individuals that convert to schizophrenia, 62 whereas [ 18 F]DOPA uptake was not found to be increased in healthy co-twins of patients of schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain

et al. 2015

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The dopamine (DA) and serotonin (5-HT) neurotransmission systems are of fundamental importance for normal brain function and serve as targets for treatment of major neuropsychiatric disorders. Despite central interest for these neurotransmission systems in psychiatry research, little is known about the regulation of receptor and transporter density levels. This lack of knowledge obscures interpretation of differences in protein availability reported in psychiatric patients. In this study, we used positron emission tomography (PET) in a twin design to estimate the relative contribution of genetic and environmental factors, respectively, on dopaminergic and serotonergic markers in the living human brain. Eleven monozygotic and 10 dizygotic healthy male twin pairs were examined with PET and [(11)C]raclopride binding to the D2- and D3-dopamine receptor and [(11)C]WAY100635 binding to the serotonin 5-HT1A receptor. Heritability, shared environmental effects and individual-specific non-shared effects were estimated for regional D2/3 and 5-HT1A receptor availability in projection areas. We found a major contribution of genetic factors (0.67) on individual variability in striatal D2/3 receptor binding and a major contribution of environmental factors (pairwise shared and unique individual; 0.70-0.75) on neocortical 5-HT1A receptor binding. Our findings indicate that individual variation in neuroreceptor availability in the adult brain is the end point of a nature-nurture interplay, and call for increased efforts to identify not only the genetic but also the environmental factors that influence neurotransmission in health and disease.

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“…Inasmuch as BP ND represents the receptor pool accessible to radiotracer, it can be influenced by both receptor density and the concentration of intrasynaptic dopamine (Ito et al, 2011). Nonetheless, deficit in striatal D2-type BP ND , measured at rest in stimulant users, has been considered to reflect below-control concentrations of D2-type receptors and reduced capacity for signaling through D2-type dopamine receptors rather than enhanced resting intrasynaptic dopamine concentration (Volkow et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Emotion dysregulation and amygdala dopamine D2-type receptor availability in methamphetamine users

Okita

Ghahremani

Payer

et al. 2016

Drug and Alcohol Dependence

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Background Individuals who use methamphetamine chronically exhibit emotional and dopaminergic neurochemical deficits. Although the amygdala has an important role in emotion processing and receives dopaminergic innervation, little is known about how dopamine transmission in this region contributes to emotion regulation. This investigation aimed to evaluate emotion regulation in subjects who met DSM-IV criteria for methamphetamine dependence, and to test for a relationship between self-reports of difficulty in emotion regulation and D2-type dopamine receptor availability in the amygdala. Method Ninety-four methamphetamine-using and 102 healthy-control subjects completed the Difficulties in Emotion Regulation Scale (DERS); 33 of those who used methamphetamine completed the Addiction Severity Index (ASI). A subset of 27 methamphetamine-group and 20 control-group subjects completed positron emission tomography with [18F]fallypride to assay amygdala D2-type dopamine receptor availability, measured as binding potential (BPND). Results The methamphetamine group scored higher than the control group on the DERS total score (p < 0.001), with DERS total score positively correlated with the Drug Composite Score on the ASI (p = 0.02) in the methamphetamine group. The DERS total score was positively correlated with amygdala BPND in both groups and the combined group of participants (combined: r = 0.331, p = 0.02), and the groups did not differ in this relationship. Conclusion These findings highlight problems with emotion regulation linked to methamphetamine use, possibly contributing to personal and interpersonal behavioral problems. They also suggest that D2-type dopamine receptors in the amygdala contribute to emotion regulation in both healthy and methamphetamine-using subjects.

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Relation between Presynaptic and Postsynaptic Dopaminergic Functions Measured by Positron Emission Tomography: Implication of Dopaminergic Tone

Cited by 48 publications

References 43 publications

Superiority illusion arises from resting-state brain networks modulated by dopamine

Superiority illusion arises from resting-state brain networks modulated by dopamine

Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain

Emotion dysregulation and amygdala dopamine D2-type receptor availability in methamphetamine users

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