Relation Between Progression and Regression of Atherosclerotic Left Main Coronary Artery Disease and Serum Cholesterol Levels as Assessed With Serial Long-Term (≥12 Months) Follow-Up Intravascular Ultrasound

Abstract

Background-The

Aggressive Very Low-Density Lipoprotein (VLDL) and LDL Lowering by Gene Transfer of the VLDL Receptor Combined with a Low-Fat Diet Regimen Induces Regression and Reduces Macrophage Content in Advanced Atherosclerotic Lesions in LDL Receptor-Deficient Mice

“…This also appears to be the case in humans. [47][48][49][50][51][52][53] Like all animal models of human disease, mouse models of atherosclerosis and lesion regression have several limitations. Importantly, although the mouse appears to be a suitable model for studies of events leading to formation of advanced plaques and even plaque rupture, 54 mice seldom show signs of myocardial infarctions or strokes.…”

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

“…In a study of 107 patients with angiographically insignificant coronary atherosclerosis, left main coronary artery disease detected by IVUS was significantly associated with future coronary events 63 . IVUS studies have shown that the rate of plaque growth in the left main coronary artery correlates with traditional risk factors 64,65 . Patients at greatest risk of cardiovascular events, as determined by the PROCAM, SCORE, and Framingham CVD algorithms, exhibited significantly greater plaque progression between baseline and follow-up (median 14 months).…”

Can statins improve outcome in colorectal surgery?: Part I

“…Plainly explained, increased LDL leads to more fatty deposits and formation of platelets in the endothelium of arteries, producing thicker walls and narrowed lu-men of vessels (atherosclerosis) with functional involvement of several organs. Statins reduce LDL, as well as the size of platelets in coronary arteries [2][3][4] . Several studies have been highlighted to show that statins reduce the incidence of coronary artery diseases and cerebrovascular lesions, and improve the survival rate of patients with coronary artery diseases [5][6][7][8] ; benefits can be obtained even in the beginning of the treatment 3 .…”