Relation between red blood cell distribution width and mortality after acute myocardial infarction

Sangoi, Manuela B.; Silva, Sandra H. Da; Silva, José E. Paz da; Moresco, Rafael Noal

doi:10.1016/j.ijcard.2010.10.084

Cited by 51 publications

(35 citation statements)

References 18 publications

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“…RDW demonstrated similar predictive ability for mortality in several other studies on HF patients [97,98] and the strength of prediction was additive to brain-type natriuretic peptide [99,100]. Furthermore, in patients with coronary artery disease, RDW was strongly associated with mortality [90,101,102], incident HF, stroke and acute cardiovascular events [90]. Mortality prediction was also demonstrated in other high-risk population including acute kidney injury, pulmonary hypertension, pulmonary embolism, stroke, peripheral artery disease, and critically ill patients [89].…”

Section: High-risk Populationssupporting

confidence: 60%

Novel biomarkers with potential for cardiovascular risk reclassification

et al. 2016

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Precise estimation of the absolute risk for CVD events is necessary when making treatment recommendations for patients. A number of multivariate risk models have been developed for estimation of cardiovascular risk in asymptomatic individuals based upon assessment of multiple variables. Due to the inherent limitation of risk models, several novel risk markers including serum biomarkers have been studied in an attempt to improve the cardiovascular risk prediction above and beyond the established risk factors. In this review, we discuss the role of underappreciated biomarkers such as red cell distribution width (RDW), cystatin C (cysC), and homocysteine (Hcy) as well as imaging biomarkers in cardiovascular risk reclassification, and highlight their utility as additional source of information in patients with intermediate risk.

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Section: High-risk Populationssupporting

confidence: 60%

Novel biomarkers with potential for cardiovascular risk reclassification

et al. 2016

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“…RDW is a simple laboratory test used to evaluate variability in the size and form of red blood cells. Recently, high RDW has been associated with increased mortality in patients with coronary disease [1]–[3], heart failure [4]–[7], pulmonary hypertension [8], acute pulmonary embolism [9], cardiac arrest [10], stroke [11], liver disease [12], [13] and peripheral artery disease [14]. High RDW has been also associated with increased mortality in the general population [15], [16].…”

Section: Introductionmentioning

confidence: 99%

Red Blood Cell Distribution Width during the First Week Is Associated with Severity and Mortality in Septic Patients

et al. 2014

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ObjectiveHigher values of red blood cell distribution width (RDW) have been found in non-surviving than in surviving septic patients. However, it is unknown whether RDW during the first week of sepsis evolution is associated with sepsis severity and early mortality, oxidative stress and inflammation states, and these were the aims of the study.MethodsWe performed a prospective, observational, multicenter study in six Spanish Intensive Care Units with 297 severe septic patients. We measured RDW, serum levels of malondialdehyde (MDA) to assess oxidative stress, and tumour necrosis factor (TNF)-α to assess inflammation at days 1, 4, and 8. The end-point was 30-day mortality.ResultsWe found higher RDW in non-surviving (n = 104) than in surviving (n = 193) septic patients at day 1 (p = 0.001), day 4 (p = 0.001), and day 8 (p = 0.002) of ICU admission. Cox regression analyses showed that RDW at day 1 (p<0.001), 4 (p = 0.005) and 8 (p = 0.03) were associated with 30-day mortality. Receiver operating characteristic curves showed that RDW at day 1 (p<0.001), 4 (p<0.001), and 8 (p<0.001) could be used to predict 30-day mortality. RDW showed a positive correlation with serum MDA levels at day 1 and day 4, with serum TNF-α levels at days 4 and 8, and with SOFA score at days 1, 4 and 8.ConclusionsThe major findings of our study were that non-surviving septic patients showed persistently higher RDW during the first week of ICU stay than survivors, that RDW during the first week was associated with sepsis severity and mortality, that RDW during the first week could be used as biomarker of outcome in septic patients, and that there was an association between RDW, serum MDA levels, and serum TNF-α levels during the first week.

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“…For several decades, RDW has been used to differentiate causes of anemia (2). Recently, several studies showed that elevated RDW predicts severe morbidity and mortality in cardiovascular diseases such as acute and chronic congestive heart failure (CHF) (3,4), acute myocardial infarction (5), pulmonary hypertension (6), peripheral artery disease (7), and stroke (8). Moreover, although the mechanism of association between RDW and mortality is unclear, some studies have reported that RDW is predictive of all-cause mortality in critically ill or ICU patients (9,10).…”

Section: Introductionmentioning

confidence: 99%

Red Blood Cell Distribution Width Is an Independent Predictor of Mortality in Patients With Gram-Negative Bacteremia

Kim

et al. 2012

Shock

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Red blood cell distribution width (RDW) is known to be a predictor of severe morbidity and mortality in some chronic diseases such as congestive heart failure. However, to our knowledge, little is known about RDW as a predictor of mortality in patients with Gram-negative bacteremia, a major nosocomial cause of intra-abdominal infections, urinary tract infections, and primary bacteremia. Therefore, we investigated whether RDW is an independent predictor of mortality in patients with Gram-negative bacteremia. Clinical characteristics, laboratory parameters, and outcomes of 161 patients with Gram-negative bacteremia from November 2010 to March 2011 diagnosed at Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, were retrospectively analyzed. The main outcome measure was 28-day all-cause mortality. The 28-day mortality rate was significantly higher in the increased RDW group compared with the normal RDW group (P < 0.001). According to multivariate Cox proportional hazard analysis, RDW levels at the onset of bacteremia (per 1% increase, P = 0.036), the Charlson index (per 1-point increase, P < 0.001), and the Sequential Organ Failure Assessment score (per 1-point increase, P = 0.001) were independent risk factors for 28-day mortality. Moreover, the nonsurvivor group had significantly higher RDW levels 72 h after the onset of bacteremia than did the survivor group (P = 0.001). In addition, the area under the curve of RDW at the onset of bacteremia, the 72-h RDW, and the Sequential Organ Failure Assessment score for 28-day mortality were 0.764 (P = 0.001), 0.802 (P < 0.001), and 0.703 (P = 0.008), respectively. Red blood cell distribution width at the onset of bacteremia was an independent predictor of mortality in patients with Gram-negative bacteremia. Also, 72-h RDW could be a predictor for all-cause mortality in patients with Gram-negative bacteremia.

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Relation between red blood cell distribution width and mortality after acute myocardial infarction

Cited by 51 publications

References 18 publications

Novel biomarkers with potential for cardiovascular risk reclassification

Novel biomarkers with potential for cardiovascular risk reclassification

Red Blood Cell Distribution Width during the First Week Is Associated with Severity and Mortality in Septic Patients

Red Blood Cell Distribution Width Is an Independent Predictor of Mortality in Patients With Gram-Negative Bacteremia

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