Relation between red blood cell distribution width (RDW) and all-cause mortality at two years in an unselected population referred for coronary angiography

Çavuşoğlu, Erdal; Chopra, Vineet; Gupta, Amit; Battala, Venkata R.; Poludasu, Shyam; Eng, Calvin; Marmur, Jonathan D.

doi:10.1016/j.ijcard.2008.11.187

Cited by 184 publications

(151 citation statements)

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“…On the other hand, in consequence of more intensive medical drug use in our study, the effects of CRP and inflammatory cells on RDW and their relationships with CAD may had been blunted in multivariate analysis. If this speculative opinion is true, no effect of medical drugs on RDW may Of late years, RDW level was searched in patients with chronic heart failure, previous MI, primary PCI and also broad-based community screening studies and found that RDW is related to mortality even in patients without anemia (3)(4)(5)(18)(19)(20). Because all previous studies have provided the mortality and morbidity information related to RDW, novel pathophysiologic insight for underlying mechanisms are still speculative, and there is not any proved evidence for the possible causative role of RDW for the development of CAD and increased allcause mortality.…”

Section: Discussionmentioning

confidence: 99%

Red Blood Cell Distribution Width (RDW) and its Association with Coronary Atherosclerotic Burden in Patients with Stable Angina Pectoris

Çetin¹,

Kocaman²,

Bostan

et al. 2012

ELECTRON J GEN MED

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Section: Discussionmentioning

confidence: 99%

Red Blood Cell Distribution Width (RDW) and its Association with Coronary Atherosclerotic Burden in Patients with Stable Angina Pectoris

Çetin¹,

Kocaman²,

Bostan

et al. 2012

ELECTRON J GEN MED

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“…[1][2][3][4][5] Furthermore, Oh, et al showed a novel relation between higher RDW and elevated E/E' (early mitral inflow velocity to early diastolic mitral annual velocity) in patients with acute heart failure, suggesting that RDW is associated with elevated left ventricular filling pressure. 9) Fukuta, et al showed that higher RDW was associated with elevated BNP in patients with CAD, suggesting that neurohumoral activation is a mechanistic link between increased RDW and adverse clinical outcomes in patients with CAD.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies showed a strong independent association between higher levels of RDW and the risk of adverse cardiovascular outcomes in patients with heart failure, coronary artery disease, and pulmonary hypertension. [1][2][3][4][5] However, the underlying mechanisms of the beneficial prognostic marker remain unknown. Red blood cells transport oxygen to tissues such as peripheral muscle.…”

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confidence: 99%

“…Accordingly, we speculate that higher levels of RDW may affect oxygen transport capacity, which is associated with adverse clinical outcomes. [1][2][3][4][5] Exercise training increases aerobic capacity and exercise tolerance, 6) and improves prognosis in patients with coronary artery disease (CAD). A previous study has shown that higher levels of RDW were related to impaired exercise capacity and exercise training decreased RDW in patients with chronic heart failure, 7) but no study has reported them in patients with CAD.…”

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confidence: 99%

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Effect of Exercise Training on Red Blood Cell Distribution Width as a Marker of Impaired Exercise Tolerance in Patients With Coronary Artery Disease

et al. 2016

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SummaryRed blood cell distribution width (RDW) can predict mortality in cardiovascular disease. However, the underlying mechanisms of the beneficial prognostic marker remain unknown. The purpose of this study was to investigate whether the RDW is related to impaired exercise tolerance and exercise training (ET) effect on RDW in patients with coronary artery disease (CAD).Seventy-eight patients who underwent ET by supervised bicycle ergometer during 3 weeks served as the ET group whereas 30 patients who did not undergo ET were the control group. Exercise stress test with cardiopulmonary analysis was performed in the ET group. Peak oxygen uptake (from 14.1 ± 4.0 to 15.1 ± 3.8 mL/kg/minute, P < 0.05) significantly increased in the ET group. Although RDW and serum erythropoietin concentration (EP) before the observation period did not differ between the ET and control groups, RDW (from 44.4 ± 4.7 to 43.4 ± 3.8 fL, P < 0.01) and EP (from 27.9 ± 15.8 to 22.9 ± 8.2 mIU/mL, P < 0.005) significantly decreased in the ET group, however, these parameters did not change in the control group. In the ET group, RDW was negatively correlated with peak oxygen uptake (r = -0.55, P < 0.01) and the changes in RDW before and after ET were positively correlated with the changes in EP (r = 0.39, P < 0.005).Thus, ET increases exercise tolerance and decreases RDW in association with increased oxygen uptake in patients with CAD. (Int Heart J 2016; 57: 553-557)

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“…8 The underlying mechanisms explaining this relationship is not clear, but possible mechanisms include inflammatory and neurohormonal effects. Abbreviations: MPV, mean platelet volume; NLR, neutrophil-tolymphocyte ratio; RDW, red-cell distribution width…”

Section: Discussionmentioning

confidence: 99%

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Karaçağlar

Bal²,

Çiftci³

et al. 2015

Exp Clin Transplant

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Objectives: Hematologic parameters, such as mean platelet volume, red-cell distribution width, and neutrophil-to-lymphocyte ratio, have prognostic value in multiple cardiac conditions such as stable angina pectoris, acute coronary syndromes, and heart failure. However, no previous studies have evaluated the association between hematologic parameters and asymptomatic graft rejection after heart transplant. We evaluated the role of hematologic parameters for detecting asymptomatic graft rejection after heart transplant. Materials and Methods: We retrospectively evaluated medical records of 47 adult patients who underwent orthotopic heart transplant between February 25, 2005, and July 6, 2014, in our hospital, noting their hematologic parameters before each biopsy. Two groups were created according to biopsy results: rejection and no-rejection. Results: We excluded 4 patients who died during the first month posttransplant owing to early complications. We evaluated 422 endomyocardial biopsy results of 43 adult patients (mean age, 43.4 ± 11.4 y; 14 women). Mean follow-up was 33 months. A total of 109 biopsies performed because of clinical suspicion of rejection were excluded. Redcell distribution width levels were similar between groups (17.2% ± 2.6% in the rejection group and 17.1% ± 2.5% in the no-rejection group; P = .856).Neutrophil-to-lymphocyte ratio was similar between groups (7.8 ± 9.9 in the rejection group and 8.2 ± 9.7 in the no-rejection group; P = .791). Mean platelet volume levels were significantly lower in the rejection group (8.3 ± 1.3 fL) than in the no-rejection group (8.8 ± 1.8 fL) (P = .037) ( Table 1). Conclusions: According to our results, only lower mean platelet volume levels were significantly associated with asymptomatic graft rejection in patients with a transplanted heart. More detailed analyses are needed to exclude the effects of immunosuppressant drugs, and further studies are needed to clarify the exact role of hematologic parameters for detecting asymptomatic rejection after heart transplant.

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Relation between red blood cell distribution width (RDW) and all-cause mortality at two years in an unselected population referred for coronary angiography

Cited by 184 publications

References 13 publications

Red Blood Cell Distribution Width (RDW) and its Association with Coronary Atherosclerotic Burden in Patients with Stable Angina Pectoris

Red Blood Cell Distribution Width (RDW) and its Association with Coronary Atherosclerotic Burden in Patients with Stable Angina Pectoris

Effect of Exercise Training on Red Blood Cell Distribution Width as a Marker of Impaired Exercise Tolerance in Patients With Coronary Artery Disease

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