Relation Between Serum Uric Acid to Albumin Ratio and Severity of Chronic Coronary Artery Disease

Yalcinkaya, Damla; Karacali, Kadir; Ilhan, Bilal Canberk; Yarlıoğlueş, Mikail

doi:10.1177/00033197231161902

Cited by 12 publications

(9 citation statements)

References 41 publications

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“…Yalcinkaya et al divided patients with coronary artery disease (CAD) into high and low Syntax score (SS) groups. 1 UAR was significantly higher in the high SS group. They also found that UAR above 1.34 was an independent predictor of high SS with an odds ratio of 3.86 (95% confidence interval: 2.39-6.23 P < .05).…”

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confidence: 74%

“…In summary, the work by Yalcinkaya et al 1 demonstrated that UAR is a useful tool to be used in the risk stratification of CAD. Further studies on the mechanisms of UAR in affecting CAD are warranted.…”

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confidence: 96%

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confidence: 99%

“…We read with great interest the article entitled “Relation Between Serum Uric Acid to Albumin Ratio and Severity of Chronic Coronary Artery Disease” by Yalcinkaya et al 1 We congratulate the authors and would like to discuss some points about the relationship between uric acid (UA) to albumin ratio (UAR) and cardiovascular disease (CVD).…”

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Uric Acid to Albumin Ratio, A Novel Biomarker of Cardiovascular Disease

2023

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Dear editorWe read with great interest the article entitled "Relation Between Serum Uric Acid to Albumin Ratio and Severity of Chronic Coronary Artery Disease" by Yalcinkaya et al. 1 We congratulate the authors and would like to discuss some points about the relationship between uric acid (UA) to albumin ratio (UAR) and cardiovascular disease (CVD).Yalcinkaya et al. divided patients with coronary artery disease (CAD) into high and low Syntax score (SS) groups. 1 UAR was significantly higher in the high SS group. They also found that UAR above 1.34 was an independent predictor of high SS with an odds ratio of 3.86 (95% confidence interval: 2.39-6.23 P < .05). They concluded that UAR is an independent predictor of CAD severity.Interestingly, Li and colleagues 2 reported that UAR was independently correlated with long-term cardiac mortality in patients with unstable angina pectoris treated by percutaneous coronary intervention (PCI). Similarly, a study by Çınar and colleagues 3 showed that UAR has a predictive value of noreflow in ST elevation myocardial infarction patients. Furthermore, study by Selçuk et al. demonstrated UAR to be an independent predictor of new onset AF in patients with STelevation myocardial infarction. 4 These findings suggested that UAR may be a beneficial tool to be used in the risk evaluation of CAD.The mechanisms by which UAR participates in CAD and affect the severity of coronary artery remain unclear. High UA levels may be associated with the activation of the reninangiotensin system, the inhibition of nitric oxide system, as well as enhancing oxidative stress. 5 Also, albumin involves a series of biological functions in the body, including antioxidant and anti-inflammatory properties. 6 All of these is involved in the process of atherosclerosis. We infer that the real mechanisms may be multifactorial.In summary, the work by Yalcinkaya et al. 1 demonstrated that UAR is a useful tool to be used in the risk stratification of CAD. Further studies on the mechanisms of UAR in affecting CAD are warranted.

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confidence: 74%

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confidence: 96%

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Uric Acid to Albumin Ratio, A Novel Biomarker of Cardiovascular Disease

2023

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“…The findings also revealed a noteworthy correlation between UAR values and the SYNTAX score. Yalcinkaya et al [15] found that UAR levels predict disease burden in participants with chronic CAD and are significantly associated with the SYNTAX and Gensini scores.Çınar et al [34] demonstrated that in patients with STEMI who underwent primary PCI, elevated UAR levels are individual risk factors for the no-reflow phenomenon. Şaylık et al [35] determined that UAR independently predicts poor coronary collateral circulation congestion (CCC) in individuals diagnosed with chronic total occlusion of the coronary arteries.…”

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confidence: 99%

Relationship between uric acid to albumin ratio and in-stent restenosis in patients with coronary artery disease undergoing drug-eluting stenting

Liu,

Ding,

Bao

et al. 2023

Coronary Artery Disease

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Background In-stent restenosis (ISR) in patients undergoing percutaneous coronary intervention (PCI) to treat coronary artery disease (CAD) is an urgent issue in clinical practice. Recent studies have highlighted uric acid-albumin ratio (UAR) as a new marker for evaluating inflammation and oxidative stress, capable of predicting cardiovascular ailments. We aimed to examine the correlation between UAR levels and ISR in patients who underwent drug-eluting stent (DES) implantation. Methods We included 503 patients with CAD who underwent initial DES implantation and angiography during the follow-up period. Based on coronary angiographic findings, the patients were categorized into ISR (n = 73) and non-ISR groups (n = 430). Before angiography, laboratory parameters were measured for all enrolled patients. To ascertain the influential factors linked to ISR, multivariate logistic regression analysis was performed. The predictive capability of UAR in determining ISR was assessed using receiver operating characteristic (ROC) curve analysis. Statistical significance was set at P < 0.05. Results Multivariate logistic regression analysis revealed that diabetes mellitus, stent length, UAR, albumin levels, and C-reactive protein levels independently predicted ISR. ROC curve analysis revealed that UAR had an area under the curve of 0.767 (95% CI: 0.709 – 0.826) for predicting ISR and demonstrated that UAR outperformed the individual predictive abilities of uric acid and albumin for ISR. Conclusion UAR was associated with ISR in patients with CAD undergoing PCI with DES implantation. Moreover, ROC curve analysis demonstrated that UAR exhibited superior predictive accuracy for ISR compared with evaluating uric acid and albumin levels separately.

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