Relation Between Short-Term Fine-Particulate Matter Exposure and Onset of Myocardial Infarction

Sullivan, Jeffrey; Sheppard, Lianne; Schreuder, Astrid B.; Ishikawa, Naomi; Siscovick, David S.; Kaufman, Joel D.

doi:10.1097/01.ede.0000147116.34813.56

Cited by 147 publications

(100 citation statements)

References 34 publications

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“…103 Several studies have also found positive associations between elevated PM or traffic exposures over a period as brief as a few hours 109 -111 or a few days and an elevated risk for MI (Table 5). 13,110,[112][113][114][115] In general, acute increases in risk for ischemic heart disease events have been observed consistently, even as rapidly as 1 to 2 hours after exposure to elevated PM, in case-crossover analyses. 109 -111 Other studies have reported an increased risk for MI shortly after exposure to traffic.…”

Section: Specific Cardiovascular Events/conditionsmentioning

confidence: 97%

Particulate Matter Air Pollution and Cardiovascular Disease

Brook¹,

Rajagopalan²,

Pope³

et al. 2010

Circulation

Self Cite

5,433

3,225

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Abstract-In 2004, the first American Heart Association scientific statement on "Air Pollution and Cardiovascular Disease" concluded that exposure to particulate matter (PM) air pollution contributes to cardiovascular morbidity and mortality. In the interim, numerous studies have expanded our understanding of this association and further elucidated the physiological and molecular mechanisms involved. The main objective of this updated American Heart Association scientific statement is to provide a comprehensive review of the new evidence linking PM exposure with cardiovascular disease, with a specific focus on highlighting the clinical implications for researchers and healthcare providers. The writing group also sought to provide expert consensus opinions on many aspects of the current state of science and updated suggestions for areas of future research. On the basis of the findings of this review, several new conclusions were reached, including the following: Exposure to PM Ͻ2.5 m in diameter (PM 2.5 ) over a few hours to weeks can trigger cardiovascular disease-related mortality and nonfatal events; longer-term exposure (eg, a few years) increases the risk for cardiovascular mortality to an even greater extent than exposures over a few days and reduces life expectancy within more highly exposed segments of the population by several months to a few years; reductions in PM levels are associated with decreases in cardiovascular mortality within a time frame as short as a few years; and many credible pathological mechanisms have been elucidated that lend biological plausibility to these findings. It is the opinion of the writing group that the overall evidence is consistent with a causal relationship between PM 2.5 exposure and cardiovascular morbidity and mortality. This body of evidence has grown and been strengthened substantially since the first American Heart Association scientific statement was published. Finally, PM 2.5 exposure is deemed a modifiable factor that contributes to cardiovascular morbidity and mortality. (Circulation. 2010;121:2331-2378.)

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Section: Specific Cardiovascular Events/conditionsmentioning

confidence: 97%

Particulate Matter Air Pollution and Cardiovascular Disease

Brook¹,

Rajagopalan²,

Pope³

et al. 2010

Circulation

Self Cite

5,433

3,225

View full text Add to dashboard Cite

show abstract

“…A study from Rome, Italy, reported increased risk of MI associated with PM pollution, especially during warm periods, 261 but a study from King County, WA, observed no PM-MI associations. 262 In a much larger case-crossover study using data from 21 U.S. cities with Ͼ300,000 MI events, a 20-g/m 3 increase in PM 10 ambient concentration was associated with a 1.3% (95% CI, 0.6%-2%) increased risk of MI. 263,264 …”

Section: Short-term Exposure and Cardiovascularmentioning

confidence: 97%

Health Effects of Fine Particulate Air Pollution: Lines that Connect

Pope

Dockery²

2006

Journal of the Air & Waste Management Association

5,670

3,159

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Efforts to understand and mitigate the health effects of particulate matter (PM) air pollution have a rich and interesting history. This review focuses on six substantial lines of research that have been pursued since 1997 that have helped elucidate our understanding about the effects of PM on human health. There has been substantial progress in the evaluation of PM health effects at different time-scales of exposure and in the exploration of the shape of the concentration-response function. There has also been emerging evidence of PM-related cardiovascular health effects and growing knowledge regarding interconnected general pathophysiological pathways that link PM exposure with cardiopulmonary morbidity and mortality. Despite important gaps in scientific knowledge and continued reasons for some skepticism, a comprehensive evaluation of the research findings provides persuasive evidence that exposure to fine particulate air pollution has adverse effects on cardiopulmonary health. Although much of this research has been motivated by environmental public health policy, these results have important scientific, medical, and public health implications that are broader than debates over legally mandated air quality standards.

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“…Smaller studies on cardiovascular morbidity end-points generally found little evidence for effects on sudden cardiac arrest [57], myocardial infarction [58], heart rate variability [59], and measures of systemic inflammation or thrombosis [60].…”

Section: Epidemiologymentioning

confidence: 99%

Health impacts of anthropogenic biomass burning in the developed world

Sigsgaard¹,

et al. 2015

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Climate change policies have stimulated a shift towards renewable energy sources such as biomass. The economic crisis of 2008 has also increased the practice of household biomass burning as it is often cheaper than using oil, gas or electricity for heating. As a result, household biomass combustion is becoming an important source of air pollutants in the European Union.This position paper discusses the contribution of biomass combustion to pollution levels in Europe, and the emerging evidence on the adverse health effects of biomass combustion products.Epidemiological studies in the developed world have documented associations between indoor and outdoor exposure to biomass combustion products and a range of adverse health effects. A conservative estimate of the current contribution of biomass smoke to premature mortality in Europe amounts to at least 40 000 deaths per year.We conclude that emissions from current biomass combustion products negatively affect respiratory and, possibly, cardiovascular health in Europe. Biomass combustion emissions, in contrast to emissions from most other sources of air pollution, are increasing. More needs to be done to further document the health effects of biomass combustion in Europe, and to reduce emissions of harmful biomass combustion products to protect public health. @ERSpublications Biomass combustion is an important source of air pollution and ill health in the EU: emissions need to reduce http://ow.ly/RYkPk

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Relation Between Short-Term Fine-Particulate Matter Exposure and Onset of Myocardial Infarction

Abstract: Although a very small effect cannot be excluded, there was no consistent association between ambient levels of fine-particulate matter and risk of MI onset.

Cited by 147 publications

References 34 publications

Particulate Matter Air Pollution and Cardiovascular Disease

Particulate Matter Air Pollution and Cardiovascular Disease

Health Effects of Fine Particulate Air Pollution: Lines that Connect

Health impacts of anthropogenic biomass burning in the developed world

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