Relation Between Structural and Functional Connectivity in Major Depressive Disorder

Kwaasteniet, Bart de; Ruhé, Eric; Caan, Matthan W.A.; Rive, Maaike; Olabarriaga, Sílvia D.; Groefsema, Martine; Heesink, Lieke; Wingen, Guido van; Denys, Damiaan

doi:10.1016/j.biopsych.2012.12.024

Cited by 195 publications

(126 citation statements)

References 72 publications

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“…Interestingly, the ACC has repeatedly been found to display increased activity in functional studies of MDD (Mayberg et al, 2005;Savitz and Drevets, 2009;Fan et al, 2013), and thus ACC coupling seems to distinguish BPD from mood disorders. In addition to this, studies of functional connectivity in MDD have also shown decreases in resting state coupling between the ACC network and the amygdala, medial temporal lobe, and areas of the frontal and prefrontal cortices (Davey et al, 2012;de Kwaasteniet et al, 2013;Pannekoek et al, 2014). These findings of task-based and resting state ACC functional and coupling abnormalities in MDD, in comparison with those of the current study and previous research, appear to distinguish BPD from mood disorders, at least in relation to ACC function.…”

Section: Discussionsupporting

confidence: 76%

Dysregulation between emotion and theory of mind networks in borderline personality disorder

O’Neill

D'Souza

Samson

et al. 2015

Psychiatry Research: Neuroimaging

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a b s t r a c tIndividuals with borderline personality disorder (BPD) commonly display deficits in emotion regulation, but findings in the area of social cognitive (e.g., theory of mind, ToM) capacities have been heterogeneous. The aims of the current study were to investigate differences between patients with BPD and controls in functional connectivity (1) between the emotion and ToM network and (2) in the default mode network (DMN). Functional magnetic resonance imaging was used to investigate 19 healthy controls and 17 patients with BPD at rest and during ToM processing. Functional coupling was analysed. Significantly decreased functional connectivity was found for patients compared with controls between anterior cingulate cortex and three brain areas involved in ToM processes: the left superior temporal lobe, right supramarginal/inferior parietal lobes, and right middle cingulate cortex. Increased functional connectivity was found in patients compared with controls between the precuneus as the DMN seed and the left inferior frontal lobe, left precentral/middle frontal, and left middle occipital/ superior parietal lobes during rest. Reduced functional coupling between the emotional and the ToM network during ToM processing is in line with emotion-regulation dysfunctions in BPD. The increased connectivity between precuneus and frontal regions during rest might be related to extensive processing of internal thoughts and self-referential information in BPD.

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Section: Discussionsupporting

confidence: 76%

Dysregulation between emotion and theory of mind networks in borderline personality disorder

O’Neill

D'Souza

Samson

et al. 2015

Psychiatry Research: Neuroimaging

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“…However, if structural hyperconnectivity has the same potential to break down a network's functioning as has a structurally hypoconnected network, then functional hyperconnectivity might be interpreted as a sign of functional compensation in response to the structural network impairments. Exactly this pattern of connectivity dissociation has been reported previously in healthy subjects notably in fronto‐parietal networks (Eickhoff et al., 2010) and in pathological conditions such as major and late life depression (de Kwaasteniet et al., 2013; Steffens, Taylor, Denny, Bergman, & Wang, 2011; Wu et al., 2011) and stroke (Zhang et al., 2014). Alternatively, however, an increase in functional connectivity may reflect a pathological loss of inhibitory neural activity within structurally damaged cortical networks as has been shown in patients suffering from amyotrophic lateral sclerosis (Douaud, Filippini, Knight, Talbot, & Turner, 2011).…”

Section: Discussionmentioning

confidence: 99%

Structural and functional hyperconnectivity within the sensorimotor system in xenomelia

et al. 2017

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IntroductionXenomelia is a rare condition characterized by the persistent and compulsive desire for the amputation of one or more physically healthy limbs. We highlight the neurological underpinnings of xenomelia by assessing structural and functional connectivity by means of whole‐brain connectome and network analyses of regions previously implicated in empirical research in this condition.MethodsWe compared structural and functional connectivity between 13 xenomelic men with matched controls using diffusion tensor imaging combined with fiber tractography and resting state functional magnetic resonance imaging. Altered connectivity in xenomelia within the sensorimotor system has been predicted.ResultsWe found subnetworks showing structural and functional hyperconnectivity in xenomelia compared with controls. These subnetworks were lateralized to the right hemisphere and mainly comprised by nodes belonging to the sensorimotor system. In the connectome analyses, the paracentral lobule, supplementary motor area, postcentral gyrus, basal ganglia, and the cerebellum were hyperconnected to each other, whereas in the xenomelia‐specific network analyses, hyperconnected nodes have been found in the superior parietal lobule, primary and secondary somatosensory cortex, premotor cortex, basal ganglia, thalamus, and insula.ConclusionsOur study provides empirical evidence of structural and functional hyperconnectivity within the sensorimotor system including those regions that are core for the reconstruction of a coherent body image. Aberrant connectivity is a common response to focal neurological damage. As exemplified here, it may affect different brain regions differentially. Due to the small sample size, our findings must be interpreted cautiously and future studies are needed to elucidate potential associations between hyperconnectivity and limb disownership reported in xenomelia.

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“…Thereafter, a lot of interest has been devoted to deepening the understanding of how anatomical constraints shape functional connectivity (Honey et al 2010;Breakspear et al 2010;Cabral et al 2011;Deco et al 2012), and how this relationship can be affected by different pathologies (de Kwaasteniet et al 2013;van Schouwenburg et al 2013). In most of these studies, either the dynamics of FC are not taken into account, or it is modeled, but the information coming from the data and used to assess models is deduced with a static approach of FC [e.g., (Deco et al 2013b)].…”

Section: Phases Of (De)synchronization Between Functional and Structumentioning

confidence: 99%

Cerebral functional connectivity periodically (de)synchronizes with anatomical constraints

et al. 2015

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This paper studies the link between restingstate functional connectivity (FC), measured by the correlations of fMRI BOLD time courses, and structural connectivity (SC), estimated through fiber tractography. Instead of a static analysis based on the correlation between SC and FC averaged over the entire fMRI time series, we propose a dynamic analysis, based on the time evolution of the correlation between SC and a suitably windowed FC. Assessing the statistical significance of the time series against random phase permutations, our data show a pronounced peak of significance for time window widths around 20-30 TR (40-60 s). Using the appropriate window width, we show that FC patterns oscillate between phases of high modularity, primarily shaped by anatomy, and phases of low modularity, primarily shaped by inter-network connectivity. Building upon recent results in dynamic FC, this emphasizes the potential role of SC as a transitory architecture between different highly connected restingstate FC patterns. Finally, we show that the regions contributing the most to these whole-brain level fluctuations of FC on the supporting anatomical architecture belong to the default mode and the executive control networks Steven Laureys and Rodolphe Sepulchre contributed equally. Electronic supplementary material 123Brain Struct Funct DOI 10.1007/s00429-015-1083-y suggesting that they could be capturing consciousness-related processes such as mind wandering.

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Relation Between Structural and Functional Connectivity in Major Depressive Disorder

Cited by 195 publications

References 72 publications

Dysregulation between emotion and theory of mind networks in borderline personality disorder

Dysregulation between emotion and theory of mind networks in borderline personality disorder

Structural and functional hyperconnectivity within the sensorimotor system in xenomelia

Cerebral functional connectivity periodically (de)synchronizes with anatomical constraints

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