Relation between the action of dopamine and apomorphine and their O-methylated derivatives upon the CNS

Ernst, A. M.

doi:10.1007/bf00402361

Cited by 180 publications

(38 citation statements)

References 10 publications

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“…Gnawing started after about 30 mm. This gnawing behavlour was not like dopamme-and apomorphme-gnawing which has been described m an earlier publlcanon (Ernst, 1965), because the ammals gripped the wire of the floor and convulswely held it, all movements around the cage ceasing. During this state tremor and stereotyped movements of the head and forelegs were also marked.…”

Section: Resultsmentioning

confidence: 59%

“…7.5 mg/rat in a concentration of 7.5 mg/ml). After 5-HTP injection the animals were placed in metal cages with a wire-mesh floor on which they were able to gnaw (see Ernst, 1965). Their behaviour was observed for several hours.…”

Section: Methodsmentioning

confidence: 99%

“…However, in rodents which cannot vomit, dopa administration after pretreatment with iproniazld (which increases the content of dopamine in the brain) provokes locomotor excitement followed by intense gnawing behaviour (Ernst, 1965). It therefore seemed of interest to investigate the effect of 5-HTP (which rapidly penetrates the blood-brain barrier and increases the content of 5-HT m the brain) after pretreatment with lproniazid.…”

Section: Introductionmentioning

confidence: 99%

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The effect of 5-hydroxytryptamine and 5-hydroxytryptophan on extra-pyramidal function

Hadzović

Ernst

1969

European Journal of Pharmacology

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The effect of 5-hydroxytryptamine and 5-hydroxytryptophan on extra.pyramidal function, European J. Pharmacol. 6 (1969) 90-95 Intrapentoneal admimstratlon of 5-hydroxytryptophan (5-HTP) reduced a special form of gnawing behavlour and stereotyped movements of the head and forelegs when gwen to lpromazld-pretreated rats These effects have not been described previously. Implantation of 5-HT into the rostro-ventral part of the corpus stnatum, induced only gnawing behavlour, while only tremor was caused by the Implantation of 5-HT or 5-HTP into the substantia mgra. Accordingly, two sites of action of 5-HT were found' the rostro-ventral part of the corpus strmtum for gnawmg behavlour and the substantm mgra for tremor. To conftrm these findings, bdateral lesions were separately made m both these areas and 5 days later, 5-HTP was admimstered Lp. (with lproniazld pretreatment). The results obtained conftrmed the rostro-ventral part of the corpus striatum as the site of action for gnawing behawour, but they did not confirm the substantia nlgra as the only site of action for the tremor. 5-hydroxytryptamme effectTremor 5-hydroxytryptophan effect Lesions Implantation Gnawing behavlour Stereotyped movements

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Section: Resultsmentioning

confidence: 59%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of 5-hydroxytryptamine and 5-hydroxytryptophan on extra-pyramidal function

Hadzović

Ernst

1969

European Journal of Pharmacology

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“…The effect of apomorphine is due to direct stimulation of dopamine receptors (Ernst, 1965;Pinder, Buxton & Green, 1971). The action of morphine, however, cannot be a direct one.…”

Section: Discussionmentioning

confidence: 99%

Compulsive Gnawing in Rats After Implantation of Drugs Into the Ventral Thalamus. A Contribution to the Mechanism of Morphine Action

Bergmann¹,

Chaimovitz²,

Pasternak³

et al. 1974

British J Pharmacology

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1Implantation of morphine into various parts of the corpus striatum of rats evokes only weak gnawing responses. 2 Deposition of apomorphine, morphine or methadone in the region of the nucleus ventralis thalami produces a biphasic response, i.e. general excitation, followed by a period of intense gnawing.3 The effect of both apomorphine and morphine is blocked by chlorpromazine, haloperidol and pimozide. However, pretreatment with ca-methyltyrosine methyl ester or a-methyldopa prevents only the gnawing response to morphine, but not to apomorphine. 4 Systemic nalorphine, morphine or pethidine suppress the gnawing response, evoked by thalamic implants of apomorphine or morphine. 5 Systemic amphetamine potentiates the effect of thalamic deposits of morphine. 6 Compulsive gnawing, following implantation of morphine into the ventral region of the thalamus, probably results from enhanced production and release of catecholamines.

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“…The actions of dopamine can be attributed partly to ~-adrenergic stimulation and partly to fl-adrenergic stimulation, although several authors have suggested the existence of another receptor for this amine (Goldberg and Sjoerdsma, 1959;McDonald and Goldberg, 1963;Eble, 1964;Van Rossum, 1964;Ernst, 1965). So far no simple organ system is known which indicates stimulation of another dopamine receptor.…”

Section: Introductionmentioning

confidence: 99%

An indirect action of dopamine on the rat fundus strip mediated by 5-hydroxytryptamine

Sonneville¹

1968

European Journal of Pharmacology

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Relation between the action of dopamine and apomorphine and their O-methylated derivatives upon the CNS

Cited by 180 publications

References 10 publications

The effect of 5-hydroxytryptamine and 5-hydroxytryptophan on extra-pyramidal function

The effect of 5-hydroxytryptamine and 5-hydroxytryptophan on extra-pyramidal function

Compulsive Gnawing in Rats After Implantation of Drugs Into the Ventral Thalamus. A Contribution to the Mechanism of Morphine Action

An indirect action of dopamine on the rat fundus strip mediated by 5-hydroxytryptamine

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