Relation Between the Corticospinal Tract State and Activities of Daily Living in Patients With Intracerebral Hemorrhage

Abstract

Background and Purpose: We investigated the relation between the ipsilesional corticospinal tract (CST) state and activity of daily living independence in patients with chronic intracerebral hemorrhage. Methods: Fifty-six consecutive patients with unilateral intracerebral hemorrhage and 38 healthy control subjects were recruited for this study. The Motricity index and the modified Barthel index were used to evaluate motor function of the affected extremities and activity of daily living independence, respectively. The diffusion tensor imaging parameter values for fractional anisotropy (FA) and voxel number (VN) of the CST were determined. Ratios of the ipsilesional to the contralesional CST measures were calculated and are presented as the CST-ratio (FA value and VN). Results: The FA value and VN of the ipsilesional CST and the CST-ratio in the patient group were lower than those of the control group ( P <0.05). There was a strong positive correlation between the Motricity index score of the affected extremities and the modified Barthel index score ( P <0.05), while the FA value and VN of the ipsilesional CST and the CST-ratio showed moderate and strong positive correlations with the Motricity index and modified Barthel index scores, respectively ( P <0.05). In addition, the VN of the ipsilesional CST showed excellent utility as a classifier, whereas the FA value of the ipsilesional CST and the FA value and VN of the CST-ratio showed good classifier utility ( P <0.05). Conclusions: We demonstrated that impairment of activity of daily living independency was closely related to the injury severity of the ipsilesional CST in patients with chronic intracerebral hemorrhage. In addition, the injury severity of the ipsilesional CST can be used to classify the degree of activity of daily living independency. REGISTRATION: URL: http://www.e-irb.com/index.jsp ; Unique identifier: 2021-03-014.

Oxymatrine ameliorates white matter injury by modulating gut microbiota after intracerebral hemorrhage in mice

“…The severity of WMI is closely related to neuromotor dysfunction in ICH patients. 7 In present study, OMT significantly alleviated WMI in the peri-hematoma region at 14 days after ICH. The less extensive WMI in the primary lesion may be account for better neurological function recovery after ICH.…”

“…The severity of WMI is closely related to neuromotor dysfunction in ICH patients 7 . In present study, OMT significantly alleviated WMI in the peri‐hematoma region at 14 days after ICH.…”

“…However, more attention was paid to the progression and repairment of axonal degeneration and demyelination around primary brain lesions, and little was known about the pathological changes of whiter matter ber tracts of the spinal cord, especially the corticospinal tract (CST), as well as its role in neurobehavioral recovery. The severity of ipsilateral CST injury was closely associated with the activity of daily living impairment in ICH patients [7]. Our previous work had rstly revealed that striatum hemorrhage induced progressive destruction of the ultrastructure integrity of the CST at the cervical enlargement under microscope, which could prolong for at least 5 weeks [8].…”

“…The severity of ipsilateral CST injury was closely associated with the activity of daily living impairment in ICH patients. 7 Our previous work had firstly revealed that striatum hemorrhage induced progressive destruction of the ultrastructure integrity of the CST at the cervical enlargement, which could prolong for at least 5 weeks. 8 Accumulating evidence implicates intestinal bacteria is a crucial factor for the bidirectional communication between the gut and central nervous system.…”