Relation between the GRACE score and severity of atherosclerosis in acute coronary syndrome

Çakar, Mehmet Akif; Şahinkuş, Salih; Aydın, Ercan; Vatan, Mehmet Bülent; Keser, Nurgül; Akdemir, Ramazan; Gündüz, Hüseyin

doi:10.1016/j.jjcc.2013.06.017

Cited by 45 publications

(50 citation statements)

References 29 publications

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“…[8][9][10][11] These studies showed an association of GRACE and TIMI risk scores with the angiographic severity of CAD in patients with NSTEMI. Those findings were validated by our study.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the GRACE and TIMI Risk Scores in Predicting the Angiographic Severity of Coronary Artery Disease in Patients with non STelevation Myocardial Infarction

et al. 2017

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Introduction:Cardiovascular diseases account for more than 17 million deaths globally each year. This figure is expected to grow to 23.6 million by the year 2030. Coronary artery disease alone caused 7 million deaths worldwide in 2010 and it is an increase of 35% since 1990. 1 The incidence of non-ST elevation acute coronary syndrome to ST elevation myocardial infarction is increasing, probably as a result of demographic changes in the population, including progressively increasing numbers of older persons and higher rates of diabetes mellitus. 2 NSTEMI currently accounts for about 50% of all myocardial infarctions. With the increased use of beta blockers and aspirin the incidence of NSTEMI is increasing. 3 The 6-month mortality rate in the patients with NSTEMI is about 6.2% and re-hospitalization rates over the 6 month is about 20%. This type of prognosis in patients with NSTEMI can be assessed by early risk stratification. Several risk scores are developed in predicting the outcomes in patients with acute coronary syndrome including NSTEMI. The most popular risk scores are the GRACE and TIMI risk scores. These risk scores calculate the patient's risk of mortality which depends on the severity of coronary artery disease and other comorbid conditions. But estimating the possible severity of coronary artery disease by these scores before performing coronary angiography may change the therapeutic decision and the timing or intensity of interventions.

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“…[8][9][10][11] These studies showed an association of GRACE and TIMI risk scores with the angiographic severity of CAD in patients with NSTEMI. Those findings were validated by our study.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the GRACE and TIMI Risk Scores in Predicting the Angiographic Severity of Coronary Artery Disease in Patients with non STelevation Myocardial Infarction

et al. 2017

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“…The primary endpoint for the present analysis was the incidence of major adverse cardiac and cerebrovascular events (MACCE), which were defined as all-cause death, myocardial infarction, congestive heart failure, or cerebrovascular disorder (stroke or transient ischemic attack). Secondary endpoints included the development of CI-AKI defined as an increase in serum creatinine of more than 25% or 0.5 mg/dL from the baseline within 1 week after contrast exposure [7]. The serum creatinine concentration was not available on day 2 or 3 for 25% of the patients, and we used the value obtained within 1 week after contrast exposure.…”

Section: Study Endpointsmentioning

confidence: 99%

“…Sgura et al demonstrated that the MRS can also be applied in an ST-elevation myocardial infarction (STEMI) population and is able to predict CI-AKI development and to discriminate between low-, medium-, high-, and very high-risk patient subgroups for consequent poor clinical outcomes during both short-and long-term follow-ups [6]. Prediction of long-term clinical outcomes in patients with coronary artery disease (CAD) treated with elective and emergent PCI except for STEMI patients is also important as is the prediction of CI-AKI development and early risk stratification [7,8]. However, the association of the MRS with long-term prognosis in patients treated with PCI has not been fully reported.…”

mentioning

confidence: 99%

Effect of the Mehran risk score for the prediction of clinical outcomes after percutaneous coronary intervention

Sato

Hoshi

Kakefuda

et al. 2015

Journal of Cardiology

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“…Besides the original function for risk stratification, recent studies showed that the GRACE score has significant value for assessing the severity and extent of coronary artery stenosis in patients with ACS [19]. Patients with high GRACE score have more severe CAD.…”

Section: Discussionmentioning

confidence: 99%

Association of Circulating IGFBP1 Level with the Severity of Coronary Artery Lesions in Patients with Unstable Angina

et al. 2017

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Aims. Local IGFBP1 level was reported to affect the development of coronary artery plaque. This study investigated the association of circulating IGFBP1 level with the severity of coronary artery lesions in patients with unstable angina. Materials and Methods. In 112 consecutive patients with clinically diagnosed unstable angina, admitted from July 2014 to July 2015, we studied the correlations of circulating IGFBP1 and the severity of coronary artery disease (CAD). Results. All patients underwent scheduled coronary angiography, and 67 cases were diagnosed with critical and 45 with noncritical CAD. Of the 67 critical CAD patients, 41 (61.19%) presented with multivessel and 26 (38.81%) with single-vessel lesions. IGFBP1 levels were higher in patients with multivessel than those with single-vessel lesions. Moreover, the IGFBP1 level was positively correlated with the GRACE score. Among clinical variables, the IGFBP1 level was correlated with HDL-C. IGFBP1 alone (cutoff 20.86 ng/ml) demonstrated a sensitivity of 0.448 and specificity of 0.933 in predicting CAD. Combination of IGFBP1 and HDL-C had a sensitivity of 0.821 and specificity of 0.800 in predicting CAD. Conclusions. Circulating IGFBP1 level positively correlated with the severity of CAD. IGFBP1, when combined with HDL-C, might be useful in screening for high risk CAD patients.

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Relation between the GRACE score and severity of atherosclerosis in acute coronary syndrome

Abstract: Our study demonstrates that the GRACE score has significant value for assessing the severity and extent of coronary artery stenosis in patients with non-ST-elevation acute coronary syndrome.

Cited by 45 publications

References 29 publications

Comparison of the GRACE and TIMI Risk Scores in Predicting the Angiographic Severity of Coronary Artery Disease in Patients with non STelevation Myocardial Infarction

Comparison of the GRACE and TIMI Risk Scores in Predicting the Angiographic Severity of Coronary Artery Disease in Patients with non STelevation Myocardial Infarction

Effect of the Mehran risk score for the prediction of clinical outcomes after percutaneous coronary intervention

Association of Circulating IGFBP1 Level with the Severity of Coronary Artery Lesions in Patients with Unstable Angina

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