Relation Between Vitamin D Insufficiency, Bone Density, and Bone Metabolism in Healthy Postmenopausal Women

Mezquita-Raya, Pedro; Muñóz-Torres, Manuel; Luna, Juan de Dios; Luna, Victoria; Rodríguez, Fernando López; Torres-Vela, Elena; Escobar-Jiménez, Fernándo

doi:10.1359/jbmr.2001.16.8.1408

Cited by 183 publications

(102 citation statements)

References 36 publications

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“…The fall in 25-hydroxyvitamin D with age seen in this study seems consistent with the findings of others (Chapuy et al, 1997;Jacques et al, 1997;Malabanan et al, 1998;Mezquita-Raya et al, 2001;Vieth et al, 2003;von Mühlen et al, 2005;Arabi et al, 2010), though not all (Harris et al, 2000;Tangpricha et al, 2002;Christensen et al, 2010). The rise in iPTH levels with age seems to occur whatever the levels of 25-hydroxyvitamin D and does not seem to be explained just by the vitamin D3 nutritional status.…”

Section: Discussionsupporting

confidence: 91%

Vitamin D deficiency in Spain: a population-based cohort study

et al. 2010

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Background: Vitamin D deficiency is common worldwide. No homogenous reference values have yet been established and no studies of values have been conducted in Spain involving a large number of participants. Objective: To study the population concentrations of vitamin D in a representative sample of the Spanish population. Subjects/Methods: The study involved two cohorts from Spain, the Asturias study and the Pizarra study, which are two prospective, population-based studies involving 2260 participants. In 1262 subjects (age: 20-83 years) we studied 25-hydroxyvitamin D, intact parathyroid hormone (iPTH), calcium, phosphorus and creatinine.

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Section: Discussionsupporting

confidence: 91%

Vitamin D deficiency in Spain: a population-based cohort study

et al. 2010

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“…A seasonal variation of biochemical markers of bone turnover has been shown, with a higher turnover reported in wintertime compared to summertime (Chapuy et al, 1996;Woitge et al, 1998). Mezquita-Raya et al (2001) observed no significant differences in biochemical markers of bone turnover in postmenopausal women with high and low vitamin D status, although they did observe that individuals with vitamin D insufficiency (25(OH)D o40 nmol/l) had a significantly lower BMD. Evidence has shown that there is a direct relationship between vitamin D status and BMD (Aguado et al, 2000).…”

Section: Discussionmentioning

confidence: 86%

“…While Pepe et al (2005) suggested that 25(OH)D concentrations were the main factor determining the circulating levels of PTH, it has also been reported that PTH concentrations only rise when 25(OH)D concentrations are deficient and fall below 40 nmol/l (Mezquita-Raya et al, 2001;Jesudason et al, 2002). In the current study, we did not observe a direct association between 25(OH)D and PTH levels, and observed that even when 25(OH)D concentrations were very low (o30 nmol/l), PTH remained within normal reference ranges.…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults

et al. 2006

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Objective: To assess the vitamin D status of healthy young people living in Northern Ireland and the effect of vitamin D supplementation on vitamin D status and bone turnover. Design: Double-blinded randomised controlled intervention study. Setting: University of Ulster, Coleraine, Northern Ireland. Subjects: In total, 30 apparently healthy students (15 male and 15 female subjects), aged 18-27 years, were recruited from the university, with 27 completing the intervention. Interventions: Subjects were randomly assigned, to receive either 15 mg (600 IU) vitamin D 3 and 1500 mg calcium/day (vitamin D group), or 1500 mg calcium/day (control group) for 8 weeks between January and March. Vitamin D status, bone turnover markers, serum calcium and parathyroid hormone concentrations were measured at baseline and post intervention.

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“…Besides having a reduced efficiency for intestinal calcium absorption (54 -56), the elderly also have an increased incidence of vitamin D insufficiency (125,126). While vitamin D insufficiency may adversely affect intestinal calcium absorption, it could further increase PTH values (127), which are already increased in the elderly (128,129). Such increases in PTH values could decrease serum phosphorus values (58,127) and also act to increase calcium reabsorption in the distal tubule.…”

Section: Vitamin Dmentioning

confidence: 99%