Relation between vitamin D level and severity, symptomatology and cognitive dysfunction of major depressive disorder—A sample of Egyptian patients

Elseesy, Sandra W.; Goueli, Tamer; Mostafa, Akmal; Afif, Alaa; Khalil, Mohamed

doi:10.1016/j.npbr.2019.12.001

Cited by 4 publications

(4 citation statements)

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“…Because it regulates neurotransmission and provides neuroprotection. Vitamin D insufficiency may cause inactivated receptors and may result in depression [20]. This study found a statistically significant difference in vitamin D levels between males and females, with females being more deficient.…”

Section: Discussionmentioning

confidence: 50%

“…Only a subgroup of depressed individuals exhibits decreased serotonin activity, which is unquestionably crucial to the pathophysiology of depression. The statistical analysis in Table 2, showed that positive correlation between and serotonin in adolescent students Neuroprotection and neurotransmission modulation are aided by vitamin D. Thus, depression may arise from a vitamin D deficit due to inactivated receptors [29].…”

Section: Discussionmentioning

confidence: 98%

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Prediction of Vitamin D and Serotonin levels with increased risk Depressive in Adolescent Students

Wajid,

Sharba

2024

BIO Web Conf.

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Vitamin D deficiency (Vt.D) is common in adolescents and is influenced by some factors, including puberty. It impacted serotonin levels, thus increasing the risk of depression. This study was conducted to assess the association between vitamin D deficiency and depression and its effect on adolescent students. A cross-sectional study of 130 adolescent students aged 12-18 years, between November 2023 to February 2024. This study investigated serum Vt.D, serotonin levels, and hematological indices such as (RBC, Hb, MCV, and MCH, of adolescents, in addition, it was dependent on the Beck Depression Inventory to calculate scales of depression. 130 adolescent students were enrolled aged 12-18, mean ± SD: 14.85±2.19. The results indicated that 77(59.2%) students had depression symptoms, median (IQR) of scores16(13₋21.5), and 53(40.8%) adolescents with non-depressed (scores 5(2.5₋7), who were considered as the control group, a statistically significant between these groups (p=0.035). Depression was significantly more prevalent in females 46(59.7%) than males 31(40.3%), p=0.014. Deficiency Vt.D was found in 63.6% of the total depressive adolescents and was significantly more than nondepressive adolescents 3.8%, p<0.0001, with (B: 3.199, OR: 24.5, 95%CI: 5.96 -100.74). Serum Vt.D level was significantly decreased in depressive adolescent median (IQR) 18.8(13.1 ₋28.9) ng/ml, compared with non-depressed 52.22(42.2₋62.4), (p< 0.0001), and its lowest in a type of severe depression 10.74±3.52. The depressive adolescent group had significantly lower serotonin levels in deficiency Vt.D status than non-depressive groups (143.39±60.91 vs. 314.05±46.11), p = 0.001). Correlations and linear regression analysis to predict the risk factors for depression scores showed a significant negative correlation with levels of Vt.D (r=0.786, B: -0.109, 95%CI: -0.15 to -0.065, p<0.0001), and serotonin (r=0.848, B: 0.003, 95%CI: -0.032 to -0.019, p<0.0001), respectively. Deficiency Vt.D is an important risk factor for adolescents, especially in females, and is associated with an increased risk of depression in adolescent students

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 98%

Prediction of Vitamin D and Serotonin levels with increased risk Depressive in Adolescent Students

Wajid,

Sharba

2024

BIO Web Conf.

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“…An external factor that is commonly known to affect vitamin D levels is the duration a person is exposed to the sunlight (Elseesy et al, 2020). Since AD is a degenerative condition that leads to disabilities and functional decline, patients have trouble getting adequate sunlight exposure to generate enough vitamin D (Bivona et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

The association of serum 25-hydroxyvitamin D and Alzheimer’s Disease: a meta-analysis

Putri

Irfannuddin²,

Murti

et al. 2023

jika

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Serum 25-hydroxyvitamin D deficiency has been suggested as a promising prognostic factor for dementia. Meta-analysis published revealed statistically significant differences of 25-hydroxyvitamin D levels in patients with Alzheimer's disease (AD) but other studies have been published since then.The purpose of present study was to quantify the association of serum 25-hydroxyvitamin D and AD. Literature search was performed from inception up to November 22 using Pubmed database. Based on the pooled analysis, patients with Alzheimer's disease tend to have a vitamin D deficiency relative to patients with normal cognitive function. These results strongly support the involvement of vitamin D as a critical disease-modifying variable in the reduction of AD symptoms.

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“…The existence of vitamin D receptor in the prefrontal cortex and limbic system illustrates the role of vitamin D in influencing functions such as affect, emotion, and cognitive functions. 5 Some literatures on meta-analysis show that depression is associated with a Vitamin D deficiency in the body and it is also said that vitamin D supplementation is beneficial for the treatment of depression. A study conducted by Patrick and Ames found that vitamin D affects neuroendocrine function, namely the serotonin hormone.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency Linked To Depression (Systematic Review: Meta Synthesis)

Salsabila

Samsuria

Retnoningrum

et al. 2021

DMJ

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Background: Depression is a mood disorder that is marked by a persistent feeling of sadness, loss of interest; reduced energy and vitality; feelings of low self-worth or guilt; loss of appetite; disturbed sleep or insomnia; and slowness of thought or action. Vitamin D deficiency has been associated with depression. When the level of Vitamin D and serotonin is low, that leads to depression.Objective: To analyze whether vitamin D deficiency or insufficiency is associated with depression.Method: This is a Systematic Review Report. Samples were gathered from two journals – PubMed and Science Direct with specific search terms used were 'vitamin D' and 'depression', then were adjusted based on the inclusion criteria and research question. After that, the findings are combined in order to reach a conclusion so that the research question is well answered.Results: There are eleven journals that describe a link between low level of Vitamin D and symptoms of depression. The connection between the two is formed due to the neuroprotector and immunomodulatory effects of Vitamin D.Conclusion: Previous studies have shown that Vitamin D deficiency linked to depression. Keywords : Depression, level of vitamin D, vitamin D serum.

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Relation between vitamin D level and severity, symptomatology and cognitive dysfunction of major depressive disorder—A sample of Egyptian patients

Cited by 4 publications

References 44 publications

Prediction of Vitamin D and Serotonin levels with increased risk Depressive in Adolescent Students

Prediction of Vitamin D and Serotonin levels with increased risk Depressive in Adolescent Students

The association of serum 25-hydroxyvitamin D and Alzheimer’s Disease: a meta-analysis

Vitamin D Deficiency Linked To Depression (Systematic Review: Meta Synthesis)

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