2016
DOI: 10.14419/ijbas.v5i4.6707
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Relation between vitamins of the b complex, GABA and glutamate, and their role in neurocognitive disorders -Brief review

Abstract: Vitamins, especially the water-soluble complex of vitamins B, are highlighted in the daily clinical practice. Numerous studies emphasize the need for supplementation, mainly in groups with deficiency of these vitamins, such as the elderly, pregnant women, children and patients with diseases associates with cognitive disorder. Thiamine (B1), a vitamin of the diet, is an important cofactor for the three key enzymes involved in the citric acid cycle and the pentose phosphate cycle. Pyridoxine (B6) and cobalamin (… Show more

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Cited by 3 publications
(5 citation statements)
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“…Vitamin B12 in the form of methylcobalamin is required for the formation of methionine, known as a precursor of SAM, from homocysteine [ 28 ]. Furthermore, SAM is a precursor in the synthesis of melatonin and is also an enzymatic cofactor of glutathione production [ 29 ]. Melatonin has an antioxidant role, like glutathione.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Vitamin B12 in the form of methylcobalamin is required for the formation of methionine, known as a precursor of SAM, from homocysteine [ 28 ]. Furthermore, SAM is a precursor in the synthesis of melatonin and is also an enzymatic cofactor of glutathione production [ 29 ]. Melatonin has an antioxidant role, like glutathione.…”
Section: Discussionmentioning
confidence: 99%
“…Studies show that SAM synthesis can enhance cognitive performance. SAM is an essential cofactor in the pathway of synthesis of epinephrine, which is involved in learning processes and memory consolidation [ 29 , 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…Given the role of vitamin B6 or pyridoxine on metabolic reactions, neurotransmitters balance, removing oxidative agents, and inflammation [ 4 ], it is crucial to clarify the potential effect of vitamin B6 on pain and psychological disturbance in FM. Theoretically, vitamin B6 supplementation can affect pain neurobiology and modify neurotransmitter imbalance toward increased pain threshold in the nociplastic pain conditions, including FM [ 9 , 23 ]. It also may potentially modify the neuroplasticity changes occurring in psychological illness via its essential roles in the tryptophan/serotonin pathway, and catecholamines synthesis [ 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…Vitamin B6, as an essential cofactor in the metabolic reactions of homocysteine, regulates the transformation of various neurotransmitters such as GABA, epinephrine, serotonin, and melatonin which are involved in the diverse behavioral processes, including sleep, learning, memory, and sensation of pain [ 8 , 9 ]. Thereby, due to the potential effect of vitamin B6 on neuronal plasticity, it would be conceivable if it is implicated as a pain or mood modifier.…”
Section: Introductionmentioning
confidence: 99%
“…In addition to the formation of methionine from homocysteine, methionine synthase is required for the synthesis of S-Adenosyl-methionine [121,122]. SAM is a key metabolite in amino acid transmethylation responsible for the biological methylations that modify nucleic acids, fatty acids, porphyrins, phospholipids, polysaccharides, biogenic amines, and proteins, such as myelin basic protein (MBP), one of the proteins responsible for the compaction of the cytoplasmic surfaces of the myelin sheath [123,124].…”
Section: Molecular Perspectivesmentioning
confidence: 99%