Relation of Adiponectin to Cardiovascular Events and Mortality in Patients With Acute Coronary Syndrome

Nomura, Hidekimi; Arashi, Hiroyuki; Yamaguchi, Junichi; Hagiwara, Nobuhisa

doi:10.1016/j.amjcard.2020.10.053

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…The ability of serum adiponectin levels to predict the progression of acute coronary syndrome (ACS) (conditions causing a sudden decrease in blood flow) was studied, and it was concluded that increased cardiovascular events in male patients aged ≥65 years, with BMI <25 kg/m 2 , were linked to an increase in adiponectin levels. However, the predictive capability is limited in female patients <65 years, in addition to patients with BMI ≥25 kg/m 2 [ 70 ]. Cardiometabolic health benefits from high concentrations of adiponectin, although some studies link adiponectin to a higher risk of heart failure in individuals suffering from high cardiovascular risk.…”

Section: Adiponectin Plays the Key Link Between Metabolic And Cardiov...mentioning

confidence: 99%

Adiponectin System (Rescue Hormone): The Missing Link between Metabolic and Cardiovascular Diseases

Aljafary

Al-Suhaimi

2022

Pharmaceutics

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The adipose tissue, regardless of its role in generating and storing energy, acts as a key player as an endocrine tissue, producing a wide scale of cytokines/hormones called adipokines. Adipokines such as leptin, resistin, visfatin and osteopontin own pro-inflammatory effects on the cardiovascular system in some cases. In contrast, some adipokines have cardioprotective and anti-inflammatory impacts including adiponectin, omentin, and apelin. One of the key adipokines is adiponectin, the abundant peptide regulating hormone that is released mainly by adipocytes and cardiomyocytes as well as by endothelial and skeletal cells. It acts through two main receptors: AdipoR1 and AdipoR2, forming the “Adiponectin system” which effectively exerts its cellular mechanisms and responses in target cells. It regulates various metabolic processes, while adiponectin is the adipocyte hormone known for its cardioprotective impact in clinical and experimental research. It is also a well-effector metabolic adipokine, since weight loss or diet restriction show a link with rises in adiponectin concentrations, which is accompanied with increasing insulin sensitivity, glucose, and lipids-regulation via adiponectin’s antioxidant, anti-inflammatory, anti-fibrotic actions. The high adiponectin level made it an attractive player in developing therapeutical treatments for metabolic syndromes and cardiovascular disease. The elevated plasma levels of adiponectin are mostly attributed to its benefits on cardio-metabolism. In some cases, adiponectin has been paradoxically accompanied with elevated risk of cardiovascular disease, so higher adiponectin concentration is a marker of poor prediction. Thus, the adiponectin system is attractive to researchers as a biomarker of heart disease advancement and a predictor of prognosis during the term of some cardiovascular diseases and its mechanical functions in Hypertension and diabetic patients. This review highlights the physiological roles of adiponectin as an anti-inflammatory and cardioprotective hormone as well as how it plays as a biomarker and potential therapeutic tool in the cardiovascular system in adult, children, and adolescents. The adiponectin system may be seen as a rescue hormone aiding in remodeling of the cardiovascular system on both cellular and molecular levels. The paradox role of adiponectin relevant to cardiovascular mortality should be taken into consideration.

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Section: Adiponectin Plays the Key Link Between Metabolic And Cardiov...mentioning

confidence: 99%

Adiponectin System (Rescue Hormone): The Missing Link between Metabolic and Cardiovascular Diseases

Aljafary

Al-Suhaimi

2022

Pharmaceutics

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“…An increase in circulating levels of adiponectin due to adiponectin resistance development is one of the suggested explanations. However, the exact mechanism is not established yet [95].…”

Section: Adipokinesmentioning

confidence: 99%

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

Krauz,

Kempiński,

Jańczak

et al. 2024

IJMS

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Epicardial adipose tissue (EAT) is a fat deposit surrounding the heart and located under the visceral layer of the pericardium. Due to its unique features, the contribution of EAT to the pathogenesis of cardiovascular and metabolic disorders is extensively studied. Especially, EAT can be associated with the onset and development of coronary artery disease, myocardial infarction and post-infarct heart failure which all are significant problems for public health. In this article, we focus on the mechanisms of how EAT impacts acute coronary syndromes. Particular emphasis was placed on the role of inflammation and adipokines secreted by EAT. Moreover, we present how EAT affects the remodeling of the heart following myocardial infarction. We further review the role of EAT as a source of stem cells for cardiac regeneration. In addition, we describe the imaging assessment of EAT, its prognostic value, and its correlation with the clinical characteristics of patients.

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“…Higher Apn levels have been shown to be associated with increased insulin sensitivity, decreased oxidative stress, decreased inflammation, inhibited release of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) as well as decreased activation of nuclear factor κB (NF-κB) [ 19 ]. In contrast, higher Apn levels are associated with increased all-cause mortality in haemodialysis patients [ 20 ] and individuals with heart disease [ 21 ]. Similarly, in individuals with a history of ischaemic stroke, higher Apn levels are associated with an increased risk of having another ischaemic stroke [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Exploratory analysis of the effect of a controlled lifestyle intervention on inflammatory markers – the Healthy Lifestyle Community Programme (cohort 2)

et al. 2023

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Background Chronic low-grade inflammation is associated with an increased risk of chronic disease and mortality. The objective of the study was to test the effect of a healthy lifestyle intervention on biomarkers of inflammation (among other risk markers). Methods We conducted a non-randomized controlled trial with mostly middle-aged and elderly participants from the general population in rural northwest Germany (intervention: n = 114; control: n = 87). The intervention consisted of a 1-year lifestyle programme focusing on diet (largely plant-based; strongest emphasis), physical activity, stress management, and social support. High-sensitivity C-reactive protein (hs-CRP) was assessed at baseline, 10 weeks, 6 months, and 1 year. Homocysteine (Hcy) was assessed at baseline, 10 weeks, and 1 year. Adiponectin (Apn) was assessed at baseline and 10 weeks. An exploratory analysis of these inflammatory markers assessing the between-group differences with ANCOVA was conducted. Results The 1-year trajectory of hs-CRP was significantly lower in the intervention group compared to control (between-group difference: -0.8 (95% CI -1.2, -0.3) mg/l; p = 0.001; adjusted for baseline). The 1-year trajectory of Hcy was non-significantly higher in the intervention compared to control (between-group difference: 0.2 (95% CI -0.3, 0.7) µmol/l; p = 0.439; adjusted for baseline). From baseline to 10 weeks, Apn decreased significantly more in the intervention group compared to control (between-group difference: -1.6 (95% CI -2.7, -0.5) µg/ml; p = 0.004; adjusted for baseline). Conclusions Our study shows that healthy lifestyle changes can lower hs-CRP and Apn levels and are unlikely to significantly affect Hcy levels within 1 year. Trial registration German Clinical Trials Register (DRKS; reference: DRKS00018775, registered 12 Sept 2019; retrospectively registered; www.drks.de).

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Relation of Adiponectin to Cardiovascular Events and Mortality in Patients With Acute Coronary Syndrome

Cited by 6 publications

References 30 publications

Adiponectin System (Rescue Hormone): The Missing Link between Metabolic and Cardiovascular Diseases

Adiponectin System (Rescue Hormone): The Missing Link between Metabolic and Cardiovascular Diseases

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

Exploratory analysis of the effect of a controlled lifestyle intervention on inflammatory markers – the Healthy Lifestyle Community Programme (cohort 2)

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