Relation of an exaggerated rise in white blood cells after coronary bypass or cardiac valve surgery to development of atrial fibrillation postoperatively

Abdelhadi, Raed; Gurm, Hitinder S.; Wagoner, David R. Van; Chung, Mina K.

doi:10.1016/j.amjcard.2004.01.053

Cited by 165 publications

(104 citation statements)

References 8 publications

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“…In the older population, the incidence of AF is related to structural heart disease, systemic inflammation, atrial fibrosis, and impaired hemodynamics. AF in the postoperative setting is linked to a markedly elevated systemic inflammatory response subsequent to the surgical trauma, 66 leukocyte activation, 67 recovery from anesthesia, altered autonomic tone, and acute hemodynamic changes. Clearly, more research is required to elucidate the possible differences in the effects of n-3 fatty acids on AF that result from distinct underlying causes.…”

Section: Randomized Trialsmentioning

confidence: 99%

Omega-3 Fatty Acids and Cardiac Arrhythmias: Prior Studies and Recommendations for Future Research

et al. 2007

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Section: Randomized Trialsmentioning

confidence: 99%

Omega-3 Fatty Acids and Cardiac Arrhythmias: Prior Studies and Recommendations for Future Research

et al. 2007

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“…After cardiac surgery the presence of a relationship between AF development and interleukin 8 (IL-8), IL-6 and increased WBC count has been shown (15)(16)(17). In a very recent study, Rienstra et al (18) examined the 936 participants in the Framingham Heart Study original cohort and found that an increased WBC count was associated with AF incident during 5 years of follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…There was no a difference between recurrence and sinus rhythm groups in terms of age. Duration of AF was found to be significantly longer in the recurrence group compared to the sinus rhythm group [median: 16 (Fig. 2).…”

Section: Baseline Demographics and Characteristicsmentioning

confidence: 99%

Can neutrophil/lymphocyte ratio predict recurrence after electrical cardioversion in non-valvular atrial fibrillation?

Arıbaş

Akıllı²,

Gül³

et al. 2012

Anadolu Kardiyol Derg

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Objective: High neutrophil/lymphocyte ratio (NLR) has been associated with post-operative AF development in patients who underwent cardiac surgery. In this study, effectiveness of NLR for prediction of recurrence after electrical cardioversion (CV) in non-valvular AF was investigated. Methods: A total of 149 patients who underwent a successful CV were included in this prospective cohort study. Baseline complete blood cell count, routine biochemical tests, high sensitive C-reactive protein (hs-CRP), and echocardiographic measurements were examined. After CV, patients were monitored over six months for recurrence. Baseline characteristics of recurrence group were compared with sinus rhythm group by using Student`s t -test. Logistic regression analysis was used to determine predictors of recurrence.

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“…Tissue damage then ensues and fibrosis sets in. 129,131,132 Specifically, in the presence of Ca++ ions, CRP binds to phosphatidylcholine. Long-chain acylcarnitines and lysophosphatidylcholines are generated from phosphatidylcholine and can further contribute to membrane dysfunction by inhibiting the exchange of sodium and calcium ions in sarcomeres.…”

Section: The Role Of Systematic Inflammation In Atrial Remodeling Andmentioning

confidence: 99%

“…4,127,133,134 Another study correlated leukocytosis to an increased incidence in AF in post-operative cardiovascular patients. 132 Burzotta et al 135 discovered that the development of postoperative AF was linked to 174G/C polymorphism of the IL-6 promoter gene. In this particular study of 110 patients undergoing CABG, genetic analysis revealed that the GG genotype was associated with higher IL-6 plasma levels and subsequently, a greater inflammatory burden.…”

Section: Journal Of Atrial Fibrillation Featured Reviewmentioning

confidence: 99%

Atrial Remodeling And Atrial Fibrillation: Mechanistic Interactions And Clinical Implications

Hassan¹,

Al‐Ghamdi²

2009

J.A.F.I.B

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Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. The prevalence of AF increases dramatically with age and is seen in as high as 9% of individuals by the age of 80 years. In high-risk patients, the thromboembolic stroke risk can be as high as 9% per year and is associated with a 2-fold increase in mortality. Although the pathophysiological mechanism underlying the genesis of AF has been the focus of many studies, it remains only partially understood. Conventional theories focused on the presence of multiple re-entrant circuits originating in the atria that are asynchronous and conducted at various velocities through tissues with various refractory periods. Recently, rapidly firing atrial activity in the muscular sleeves at the pulmonary veins ostia or inside the pulmonary veins have been described as potential mechanism,. AF results from a complex interaction between various initiating triggers and development of abnormal atrial tissue substrate. The development of AF leads to structural and electrical changes in the atria, a process known as remodeling. To have effective surgical or catheter ablation of AF good understanding of the possible mechanism(s) is crucial.Once initiated, AF alters atrial electrical and structural properties that promote its maintenance and recurrence. The role of atrial remodeling (AR) in the development and maintenance of AF has been the subject of many animal and human studies over the past 10-15 years. This review will discuss the mechanisms of AR, the structural, electrophysiologic, and neurohormonal changes associated with AR and it is role in initiating and maintaining AF. We will also discuss briefly the role of inflammation in AR and AF initiation and maintenance, as well as, the possible therapeutic interventions to prevent AR, and hence AF, based on the current understanding of the interaction between AF and AR.

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Relation of an exaggerated rise in white blood cells after coronary bypass or cardiac valve surgery to development of atrial fibrillation postoperatively

Cited by 165 publications

References 8 publications

Omega-3 Fatty Acids and Cardiac Arrhythmias: Prior Studies and Recommendations for Future Research

Omega-3 Fatty Acids and Cardiac Arrhythmias: Prior Studies and Recommendations for Future Research

Can neutrophil/lymphocyte ratio predict recurrence after electrical cardioversion in non-valvular atrial fibrillation?

Atrial Remodeling And Atrial Fibrillation: Mechanistic Interactions And Clinical Implications

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