Relation of antral pH to gastrin release and fundal pH in dogs

Posey, E. Leonard; Franklin, Howard

doi:10.1007/bf02241937

Cited by 12 publications

(4 citation statements)

References 15 publications

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“…That they are measuring a different gastrin or peptide is quite evident, and we believe that they may have found a component of 'gastrin' which is pathological, removed by complete vagotomy, and present in most patients with duodenal ulcer. Certainly the present assay cannot detect this 'gastrin', but does detect gastrin which behaves physiologically in the same manner, as indirect evidence in animals suggests that gastrin should function (Pe Thein and Schofield, 1959;Posey and Franklin, 1967). The expert technical assistance of Miss Claire Soveny is gratefully acknowledged, as is the cooperation of the patients studied.…”

Section: Discussionmentioning

confidence: 82%

Serum gastrin in duodenal ulcer: Part III Influence of vagotomy and pylorectomy

Korman¹,

Hansky²,

Scott³

1972

Gut

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Part III Influence of vagotomy and pylorectomy SUMMARY Following truncal vagotomy and anterior pylorectomy for duodenal ulcer, fasting serum gastrin levels were higher at 84 ± 7.9 pg per ml than in unoperated patients with duodenal ulcer (16 ± 1.5 pg per ml). In response to a standard protein meal, the peak serum gastrin achieved in the vagotomized group was 259 ± 37.8 pg per ml at 75 minutes after ingestion, a much higher response than that obtained with a standard meal plus prior atropinization in the unoperated duodenal ulcer patients.These results suggest that truncal vagotomy allows release of gastrin which was previously inhibited with the vagi intact and the temporal characteristics of the response indicate that some of this gastrin is derived from an extragastric source. The results also exemplify the dependence of gastrin estimations as measured by this immunoassay on the acidity of the contents bathing the gastric antrum.

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Section: Discussionmentioning

confidence: 82%

Serum gastrin in duodenal ulcer: Part III Influence of vagotomy and pylorectomy

Korman¹,

Hansky²,

Scott³

1972

Gut

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“…The observation that the pH of antral contents at which secretary responses to feeding were reduced was consistently lower than that inhibiting resting secretion, is indicative that the effect reflects the summated effects of excitatory and inhibitory influences and is to some degree graded according to the acidity of antral digesta, a suggestion L. M. McLEAY AND D. A. TITCHEN previously made by Ash (1961 b) and demonstrated in dogs by Posey & Franklin (1967). Hill's (1968) estimate that pH 2-0 is the level at which acid secretion is inhibited in the ruminant appears to be referable to prandial secretion; resting secretion is reduced at a higher level -pH 2%7 or more.…”

Section: Discussionmentioning

confidence: 60%

Inhibition of hydrochloric acid and pepsin secretion from gastric pouches by antral pouch acidification in sheep.

McLeay¹,

Titchen²

1977

The Journal of Physiology

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SUMMARY1. Secretion of acid and pepsin from separated pouches of the body of the abomasum was studied in sheep during perfusion of antral pouches with acid solutions.2. Resting secretion of acid and pepsin was reduced by acidification of antral pouches to pH 2-7 or less.3. Increases in the secretion of HCl and pepsin normally obtained on feeding were reduced or abolished by perfusion of antral pouches with solutions at pH 1-3-2*0.4. Perfusion of antral pouches with acetylcholine at pH 2-5 failed to stimulate acid secretion as it did at a higher pH.5. Pentagastrin stimulated acid and pepsin secretion during the inhibition of secretion produced by antral pouch acidification.6. Increases in reticular motility occurred on antral pouch acidification with solutions of pH 1 1-1 3.7. The contribution of antral pH in regulating abomasal acid secretion is discussed.

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“…In the dog acid secretion in response to gastrin release is inhibited by electrolyte solutions when the antral pH is reduced below 3 and maximal inhibition occurs at a pH below 2 (Andersson and Olbe, 1964;Posey and Franklin, 1967). This inhibitory mechanism is in part dependent on the stimulus used and occurs at a pH of between 3 and 5 in response to glycine (Elwin and Andersson, 1966).…”

Section: Lack Of Inhibition Of Gastrin Releasementioning

confidence: 99%

Radioimmunoassay of gastrin: studies in pernicious anaemia

Hansky¹,

Korman²,

Soveny³

et al. 1971

Gut

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SUMMARY Serum gastrin levels in patients with pernicious anaemia were measured by immunoassay in the fasting state, following gastric perfusion with 0.9%% saline, OIN hydrochloric acid, and solutions of increasing acidity, and after the intravenous injection or infusion of secretin. The fasting serum gastrin level was measured in 21 patients with pernicious anaemia and found to be elevated at 1,036 ± 215 pg per ml. Gastric perfusion with saline (pH 4.7) caused a mean fall in serum gastrin of 30 % in four patients; perfusion with hydrochloric acid caused a further slight fall. Perfusion with solutions of increasing acidity resulted in a sharp fall in serum gastrin levels when the acidity was changed from pH 6 to pH 4. A single intravenous injection of secretin produced a mean maximal fall of 440% in the serum gastrin level in four patients, whereas continuous infusion of secretin produced a fall of 35 in four other patients. These studies suggest that the gastrin-secreting cells of the stomach are not affected by the atrophic process in pernicious anaemia and remain subject to the regulating control of acid and secretin.

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Relation of antral pH to gastrin release and fundal pH in dogs

Cited by 12 publications

References 15 publications

Serum gastrin in duodenal ulcer: Part III Influence of vagotomy and pylorectomy

Serum gastrin in duodenal ulcer: Part III Influence of vagotomy and pylorectomy

Inhibition of hydrochloric acid and pepsin secretion from gastric pouches by antral pouch acidification in sheep.

Radioimmunoassay of gastrin: studies in pernicious anaemia

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