Relation of atrophic gastritis with Helicobacter pylori -CagA+ and interleukin-1 gene polymorphisms

Sierra, Rosa A.; Une, Clas; Ramírez, Vanessa; Alpízar‐Alpízar, Warner; Gonzalez, Maria; Ramírez, José Antonio; Mascarel, A. De; Cuenca, Patricia; Pérez-Pérez, Guillermo I.; Mégraud, Françis

doi:10.3748/wjg.14.6481

Cited by 22 publications

(22 citation statements)

References 46 publications

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“…After excluding 59 articles, we were left with a total of fifteen studies (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). From each study, we extracted information on publication year, country, race/ethnicity, description of sampling procedures including selection criteria, sample size, prevalence of H. pylori infection, outcome studied, reference group, criteria for histologic classification, polymorphisms studied, genotyping method, and respective quality control.…”

Section: Systematic Review and Meta-analysismentioning

confidence: 99%

Association Between Cytokine Gene Polymorphisms and Gastric Precancerous Lesions: Systematic Review and Meta-analysis

Peleteiro

Lunet²,

Carrilho³

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Polymorphisms within interleukin-1 (IL1) and tumor necrosis factor α (TNFA) gene clusters are associated with an increased risk of gastric cancer. However, their role in gastric precancerous lesions remains poorly understood. Our objective was to perform a meta-analysis of studies addressing the association between IL1B-511, IL1RN variable number of tandem repeat, and TNFA-308 gene polymorphisms and gastric precancerous lesions, including original data from Portugal and Mozambique. Published studies on the association between these cytokine gene polymorphisms and gastric precancerous lesions were identified by systematic review, and estimates of the association were combined using random-effects meta-analysis taking into account new data obtained from Portuguese volunteer shipyard workers (n = 215) and Mozambican dyspeptic patients (n = 96) who underwent endoscopic and pathologic evaluation following the same protocol. Odds ratio (OR) estimates for intestinal metaplasia were 2.83 [95% confidence interval (95% CI), 1.15-6.96] for the IL1RN*22 genotype, 1.86 (95% CI, 1.03-3.36) for IL1B-511 T carriers, and 0.59 (95% CI, 0.12-3.04) for the TNFA-308*AA genotype in the Portuguese sample. All Mozambican subjects with intestinal metaplasia were T carriers for IL1B-511 and none had the 2 allele for IL1RN. In meta-analysis, IL1RN*22 genotype was associated with an increased risk of gastric precancerous lesions (22 The IL1RN*22 genotype seems to consistently increase the risk of gastric precancerous lesions, supporting a role for this polymorphism in the early stages of gastric carcinogenesis.

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Section: Systematic Review and Meta-analysismentioning

confidence: 99%

Association Between Cytokine Gene Polymorphisms and Gastric Precancerous Lesions: Systematic Review and Meta-analysis

Peleteiro

Lunet²,

Carrilho³

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…A number of studies have demonstrated that the alleles -511T and -31C in IL1B gene are associated with high level of cytokines and severe inflammation of the stomach (Kato et al, 2001;Sierra et al, 2008). The antiinflammatory cytokine IL1 receptor antagonist (IL1RN) contains a variable number of 86-bp tandem repeats and 5 different alleles have been detected in intron 2.…”

mentioning

confidence: 99%

Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

Kulmambetova¹,

Imanbekova²,

Logvinenko³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Oncogenesis The inflammatory response after H. pylori infection has been linked to the IL1 gene cluster. The infection induces the synthesis of IL1B which binds to its target receptor and starts the inflammatory response against the pathogen (Sierra et al, 2008). The IL1RN competitively binds to the IL1 receptor with the same affinity as IL1 without activating the inflammation cascade, modulating the effects of IL1B.…”

Section: Notementioning

confidence: 99%

IL1RN (interleukin 1 receptor antagonist)

Gómez-Flores-Ramos¹,

Torres-Flores²,

Gallegos-Arreola³

2014

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Relation of atrophic gastritis with Helicobacter pylori -CagA+ and interleukin-1 gene polymorphisms

Cited by 22 publications

References 46 publications

Association Between Cytokine Gene Polymorphisms and Gastric Precancerous Lesions: Systematic Review and Meta-analysis

Association Between Cytokine Gene Polymorphisms and Gastric Precancerous Lesions: Systematic Review and Meta-analysis

Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

IL1RN (interleukin 1 receptor antagonist)

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