Relation of Bacteria to Vitamins and Other Growth Factors

Peterson, W. H.; Peterson, Mary S.

doi:10.1128/br.9.2.49-109.1945

Cited by 59 publications

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“…In the case of MSVP-C, the doubling time increases ∼seven-fold relative to MSVP. Since C, N, and P are major components of the cells of all living organisms, while vitamins are frequently required as growth factors in many bacteria ( Peterson and Peterson, 1945 ), it is not surprising that cell growth slows considerably and the phenotype of filamentation changes in these nutrient-limited media ( Fagerbakke et al, 1996 ; Elser et al, 2000 ; Vrede et al, 2002 ). To describe the dynamics of the intercellular gap formation within the filaments, we plot the percent occupancy in the filament as a function of time.…”

Section: Resultsmentioning

confidence: 99%

Leptothrix cholodnii Response to Nutrient Limitation

et al. 2021

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Microorganisms are widely utilized for the treatment of wastewater in activated sludge systems. However, the uncontrolled growth of filamentous bacteria leads to bulking and adversely affects wastewater treatment efficiency. To clarify the nutrient requirements for filament formation, we track the growth of a filamentous bacterium, Leptothrix cholodnii SP-6 in different nutrient-limited conditions using a high aspect-ratio microfluidic chamber to follow cell-chain elongation and sheath formation. We find that limitations in Na+, K+, and Fe2+ yield no observable changes in the elongation of cell chains and sheath formation, whereas limitations of C, N, P, or vitamins lead to more pronounced changes in filament morphology; here we observe the appearance of partially empty filaments with wide intercellular gaps. We observe more dramatic differences when SP-6 cells are transferred to media lacking Mg2+ and Ca2+. Loss of Mg2+ results in cell autolysis, while removal of Ca2+ results in the catastrophic disintegration of the filaments. By simultaneously limiting both carbon and Ca2+ sources, we are able to stimulate planktonic cell generation. These findings paint a detailed picture of the ecophysiology of Leptothrix, which may lead to improved control over the unchecked growth of deleterious filamentous bacteria in water purification systems.

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Section: Resultsmentioning

confidence: 99%

Leptothrix cholodnii Response to Nutrient Limitation

et al. 2021

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“…Other metabolites seem more indicative of microbial nutrient needs and function. For example, pantothenic acid, vitamin B 5 , is involved in the synthesis of coenzyme A and is a coenzyme for many reactions involved in protein and lipid metabolism ( 41 – 43 ). This is particularly important for the processing of organic acids like malate, the main C source provided in this study.…”

Section: Discussionmentioning

confidence: 99%

Bulk and Spatially Resolved Extracellular Metabolome of Free-Living Nitrogen Fixation

Smercina

Kim

Lipton

et al. 2022

Appl Environ Microbiol

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Free-living nitrogen-fixing bacteria contribute significantly to terrestrial nitrogen availability; however, the forms of nitrogen contributed by this process are poorly understood. This is in part because of inherent challenges to studying soil microorganisms in situ , such as vast differences in scale between microorganism and ecosystem and complexities of the soil system (e.g., opacity, chemical complexity).

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Enzyme Problems in Relation to Chemotherapy, “Adaptation,” Mutations, Resistance, and Immunity

Sevag¹

1946

Advances in Enzymology - And Related Areas of Molecular Biology

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Relation of Bacteria to Vitamins and Other Growth Factors

Cited by 59 publications

References 0 publications

Leptothrix cholodnii Response to Nutrient Limitation

Leptothrix cholodnii Response to Nutrient Limitation

Bulk and Spatially Resolved Extracellular Metabolome of Free-Living Nitrogen Fixation

Enzyme Problems in Relation to Chemotherapy, “Adaptation,” Mutations, Resistance, and Immunity

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