Relation of Biomarkers and Cardiac Magnetic Resonance Imaging After Marathon Running

Mousavi, Negareh; Czarnecki, Andrew; Kumar, Kanwal; Fallah-Rad, Nazanin; Lytwyn, Matthew; Han, Song-Yee; Francis, Andrew; Walker, Jonathan R.; Kirkpatrick, Iain D.C.; Neilan, Tomas G.; Sharma, Sat; Jassal, Davinder S.

doi:10.1016/j.amjcard.2009.01.294

Cited by 163 publications

(107 citation statements)

References 24 publications

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“…In contrast, several studies reported transient depression of RV systolic function and RV dilation after endurance sports without prognostic consequences (5,21,24 ). These transient changes may be due to exercise-induced pulmonary hypertension or volume load (21 ).…”

Section: Biomarker Changes After Strenuous Exercisementioning

confidence: 90%

“…The exercise-induced increase in troponin could be due to release of cytoplasmic cTnT and cTnI, because exercise may increase membrane permeability of cardiomyocytes (19,20 ). This reversible membrane leakage might be due to increased mechanical stress on the cardiomyocytes, overload with free radicals, increased body temperature, or prolonged acidosis (19,21 ).…”

Section: Biomarker Changes After Strenuous Exercisementioning

confidence: 99%

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Biomarker Changes after Strenuous Exercise Can Mimic Pulmonary Embolism and Cardiac Injury—A Metaanalysis of 45 Studies

et al. 2015

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BACKGROUND: Biomarkers are well established for diagnosis of myocardial infarction [cardiac troponins, highsensitivity cardiac troponins (hs-cTn)], exclusion of acute and chronic heart failure [B-type natriuretic peptide (BNP), N-terminal proBNP (NT-proBNP)] and venous thromboembolism (D-dimers). Several studies have demonstrated acute increases in cardiac biomarkers and altered cardiac function after strenuous sports that can pretend a cardiovascular emergency and interfere with state-of-the-art clinical assessment.

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Section: Biomarker Changes After Strenuous Exercisementioning

confidence: 90%

Section: Biomarker Changes After Strenuous Exercisementioning

confidence: 99%

Biomarker Changes after Strenuous Exercise Can Mimic Pulmonary Embolism and Cardiac Injury—A Metaanalysis of 45 Studies

et al. 2015

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“…The evidence that strenuous exercise can cause alterations in the metabolism and cardiovascular system are derived from several sporting events [2][3][4][5][6] . A meta-analysis of 26 studies demonstrated that troponin elevation occurs in approximately half of the participants of endurance tests, and this increase appears to be more common in shorter duration tests 7 .…”

Section: Introductionmentioning

confidence: 99%

Efeitos agudos do exercício físico prolongado: avaliação após ultramaratona de 24 horas

Passaglia¹,

Emed²,

Barberato³

et al. 2013

Arq. Bras. Cardiol.

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“…The development of high sensitivity cardiac troponin assays has increased the analytical sensitivity with almost three orders of magnitude compared to the first generation assays, and has made it evident that cardiac troponins indeed are measurable in plasma also under normal conditions [12]. The previous belief that cardiac troponins are only released after irreversible myocardial damage is seriously challenged [13]. The vast majority of patients diagnosed with UA in the pre-troponin era have slight elevations of cardiac troponin, and using the most sensitive assays available it can be questioned whether 'true' UA does exist, i.e., without any evidence of myocardial damage ( = cardiac troponin elevation) [14,15].…”

Section: Diagnosismentioning

confidence: 99%

Acute coronary syndrome – the present and future role of biomarkers1)

Lindahl¹

2013

Clinical Chemistry and Laboratory Medicine

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Over the past two decades there have been dramatic changes in the diagnosis, treatment and prognosis of acute coronary syndrome (ACS). Several new treatment modalities have been added and the prognosis has improved dramatically. Biomarkers play a crucial role in the management of ACS. At present, cardiac troponin is the biomarker of choice for diagnosis of acute myocardial infarction (AMI). Currently, there are no other biomarkers, which can compete, neither regarding specificity nor regarding early sensitivity. However, there is still a clinical need of a biomarker able to reliably rule-in or rule-out AMI immediately on admission. MicroRNAs seem to be promising new candidates for diagnostic purposes. The optimal combination of biomarkers and new imaging techniques is another important area for research. The list of biomarkers associated with an adverse prognosis in ACS is long. However, for most of them it has been very difficult to prove an added clinical value. Only cardiac troponin, and to some degree also B-type natriuretic peptides, is widely used in clinical practice for risk assessment. Among new markers, growth differentiation factor 15 and the midregional part of the prohormone of adrenomedullin, have shown some promising results. Since the renal function is assessed in clinical routine, also markers of the renal function have gained increasing interest. Cardiac troponin has been proven useful for selection of antithrombotic, antiplatelet and invasive treatment. Besides cardiac troponin, no other markers have consistently been shown to be useful for selection of specific treatments.

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Relation of Biomarkers and Cardiac Magnetic Resonance Imaging After Marathon Running

Cited by 163 publications

References 24 publications

Biomarker Changes after Strenuous Exercise Can Mimic Pulmonary Embolism and Cardiac Injury—A Metaanalysis of 45 Studies

Biomarker Changes after Strenuous Exercise Can Mimic Pulmonary Embolism and Cardiac Injury—A Metaanalysis of 45 Studies

Efeitos agudos do exercício físico prolongado: avaliação após ultramaratona de 24 horas

Acute coronary syndrome – the present and future role of biomarkers1)

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