Relation of biotin to congenital deformities in the chick

Couch, J. R.; Cravens, W. W.; Elvehjem, C. A.; Halpin, J. G.

doi:10.1002/ar.1091000104

Cited by 51 publications

(12 citation statements)

References 14 publications

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“…by adding about 0.15 mg biotin/kg diet. Couch et al (1948a) also found zero hatchability in White Leghorns fed a biotin-devoid diet but they were able to restore hatchability to normal with n supplement of approximately 0.04 mg biotin/kg diet. They also found that the decrease in hatchability was reflected in a decrease in yolk-biotin level and that eggs containing 50p.g biotirilkg yolk did not support normal embryonic development whereas 150 &kg allowed normal development, although hatchability was still slightly reduccd (Couch e,t 01.…”

Section: Biotin Requirements Of Adult Birds Chickensmentioning

confidence: 90%

The Use of Biotin in Poultry Nutrition

Whitehead

1977

World's Poultry Science Journal

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Section: Biotin Requirements Of Adult Birds Chickensmentioning

confidence: 90%

The Use of Biotin in Poultry Nutrition

Whitehead

1977

World's Poultry Science Journal

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“…3A) are examined in the Discussion. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] were incubated with Drosophila homogenates and biocytin to conduct in vitro biotinylation (0 h = before incubation; 1 h = 1 hour after incubation); a negative control (denoted -; C-terminal aa from histone H3) and a positive control (denoted +; chemically biotinylated peptide from histone H4) were also incubated with homogenate and biocytin for 1 hour. Samples were electrophoresed and biotin in transblots was probed using streptavidin peroxidase.…”

Section: Biotinylation Of Histonesmentioning

confidence: 99%

“…For example, chickens and turkeys with marginal biotin deficiency produce eggs with higher embryonic mortality and reduced hatchability [16][17][18][19]. Likewise, in some strains of mice, biotin deficiency during pregnancy causes a substantial increase in fetal malformations and mortality [14,[20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster

Landenberger

Kabil

Harshman

et al. 2004

The Journal of Nutritional Biochemistry

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Biotin deficiency is associated with fetal malformations and activation of cell survival pathways in mammals. In this study we determined whether biotin status affects life span, stress resistance, and fertility in the fruit fly Drosophila melanogaster. Male and female flies of the Canton-S strain had free access to diets containing 6.0 (control), 4.8, 2.5, or 0 pmol biotin/100 mg. Biotin concentrations in diets correlated with activities of biotin-dependent propionyl-CoA carboxylase and biotin concentrations in fly homogenates, but not with biotinylation of histones (DNA-binding proteins). Propionyl-CoA carboxylase activities and biotin concentrations were lower in males than in females fed diets low in biotin. The life span of biotin-deficient males and females was up to 30% shorter compared to biotinsufficient controls. Exposure to oxidative stress reversed the effects of biotin status on survival in male flies: survival times increased by 40% in biotin-deficient males compared to biotin-sufficient controls. Biotin status did not affect survival of females exposed to oxidative stress. Exposure of flies to cold, heat, and oxidative stress was associated with mobilization of biotin from yet unknown sources. Biotin deficiency decreased fertility of flies. When biotin-deficient males and females were mated, the hatching rate (larvae hatched per egg) decreased by about 28% compared to biotin-2 sufficient controls. These findings are consistent with the hypothesis that biotin affects life span, stress resistance, and fertility in fruit flies.

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“…A minimum of 15 fertile embryos was therefore injected with the most suitable dose, 0.00253 m~s, through a pinhole in the shell and the survivors at 14 days cleared and stained with alizarin in order to clearly demonstrate the skeleton (6). of INAH (0.054 m~).…”

mentioning

confidence: 99%

The Lathyrogenic Effect of Isonicotinic Acid Hydrazide (Inah) on the Chick Embryo and Its Reversal by Pyridoxal

Levene

1961

The Journal of Experimental Medicine

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Evidence has been previously presented to show that lathyrogenic agents increase the solubility of collagen and the fragility of the connective tissues in the chick embryo (1). Assay systems for the detection of lathyrogenic agents have hitherto relied upon loss of weight and morphological changes in the rat as criteria of activity. In the chick embryo however, skeletal deformity can occur in the absence of changes in collagen solubility, and vice versa (1). Since the changes in the functional properties of collagen were considered to be more fundamental than changes in morphology, an assay system has been used based on collagen solubility and tissue tensile properties in the chick embryo (2).The main interest in lathyrism stems from its usefulness as a tool with which to study mechanisms by which collagen, once laid down, may be mobilized, but so far studies on the lathyrogenic nitriles, such as fl-aminopropionitrile (BAPN), have failed to elucidate such mechanisms. During an investigation into the nature of chemical groups possessing lathyrogenic activity using the chick embryo assay method, it was repeatedly noted that isonicotinic acid hydrazide ("isoniazid" or INAH) a compound effective against tuberculosis, possessed marked lathyrogenic activity. This report discusses its mode of action, comparing it with that of BAPN, the reversal of the INAH effect by pyridoxal, and the possible relevance of these findings to mechanisms of collagen mobilization. Materials and MethodsFertile eggs of the White Leghorn variety were injected v/a the chorio-allantoic membrane with isonicotinic acid hydrazide (INAH)I or ~-aminopropionitrile (BAPN) 2 in distilled water

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Relation of biotin to congenital deformities in the chick

Cited by 51 publications

References 14 publications

The Use of Biotin in Poultry Nutrition

The Use of Biotin in Poultry Nutrition

Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster

The Lathyrogenic Effect of Isonicotinic Acid Hydrazide (Inah) on the Chick Embryo and Its Reversal by Pyridoxal

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