Relation of Chemical Constitution of a Series of Esters of Picolinic Acid to Toxicity as Insecticides1

Carey, Margaret M.; Frear, D. E. H.; Dills, L. E.

doi:10.1093/jee/42.5.798

Cited by 4 publications

(1 citation statement)

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“…Octadecyl Pyridine-2-carboxylate, 2n. Data: mp 49−52 °; IR (KBr) 2959 (m), 2915 (s), 2849 (s), 1720 (s), 1594 (w), 1473 (m), 1425 (w), 1300 (m), 1237 (w), 1189 (w), 1134 (m), 1093 (w), 1030 (w), 957 (w); 1 H NMR (400 MHz, CDCl 3 ) 9.21 (d, J = 1.3, 1H), 8.75−8.73 (m, 1H), 8.29−8.26 (m, 1H), 7.37−7.34 (m, 1H), 4.33 (t, J = 6.7, 2H), 1.76 (quint, J = 7.0, 2H), 1.44−1.23 (m, 30H), 0.83 (t, J = 6.8, 3H); 13 C NMR (100 MHz, CDCl 3 ) 165.3, 153.3, 150.9, 137.0, 126.4, 123.2, 65.6, 31.9, 29.7, 29.64, 29.55, 29.5, 29.3, 29.2, 28.6, 26.0, 22.7, 14.1; MS (20 eV) 376 (M + 1 + , 5), 124 (100), 106 (56), 78 (40); TLC R f 0.35 (EtOAc/hexane, 1/10); HR-MS (FAB+) calcd for C 24 H 41 NO 2 + H: 376.3216, found: 376.3214.

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Section: Methodsmentioning

confidence: 99%

Nucleophilic Acyl Substitutions of Esters with Protic Nucleophiles Mediated by Amphoteric, Oxotitanium, and Vanadyl Species

Chen

Kuo

et al. 2005

J. Org. Chem.

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[reaction: see text] A diverse array of oxometallic species were examined as catalysts in nucleophilic acyl substitution (NAS) reactions of methyl (or ethyl) esters with protic nucleophiles. Among them, oxotitanium acetylacetonate (TiO(acac)(2)) and vanadyl chloride (VOCl(2)-(THF)(x)()) served as the most efficient and water-tolerant catalysts. Transesterifications of methyl and/or ethyl esters with functionalized (including acid- or base-sensitive) 1 degrees and 2 degrees alcohols can be carried out chemoselectively in refluxed toluene or xylene in a 1:1 substrate stoichiometry using 1 mol % catalyst loading. The resultant products were furnished in 85-100% yields by simple aqueous workup to remove water-soluble catalysts. The new NAS protocol is also amenable to amines and thiols in 74-91% yields, albeit with higher loading (2.5 equiv) of protic nucleophiles. Representative examples of commercial interests such as Padimate O and antioxidant additives for plastics were also examined to demonstrate their practical applications. A 1:1 adduct between TiO(acac)(2) and a given 1-octadecanol was identified as (C(18)H(37)O)(2)Ti(acac)(2) and was responsible for its subsequent NAS of methyl esters.

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Section: Methodsmentioning

confidence: 99%