Relation of Circulating C-Reactive Protein to Progression of Aortic Valve Stenosis

Arterial hypertension in degenerative non-severe aortic stenosis

“…In the present study we noticed significantly higher levels of inflammatory markers (WBC and CRP) in severe AS-patients what could be probably an evidence of degenerative AS severity, similar to results of Galante et al [17]. However in some studies no significant relationship between CRP levels and severity of AS was found [18,19] and the theory of inflammation exists in the early stage of evolving AS [3,19]. On the other hand, the studied non severe AS-patients had bigger atherosclerotic burden comparing to opposite group: incorrect serum lipid profile (higher level of triglyceride and cholesterol ratio), higher BMI, creatinine levels similar to other studies [6,20], frequently CAD and previous MI.…”

High levels of high sensitivity C-reactive protein predict the progression of chronic rheumatic mitral stenosis

“…This may emphasize the importance of inflammation in both the pathogenesis and the therapy of coronary heart disease and rheumatic mitral valve stenosis. Moreover, Plasma CRP concentration has significantly higher in patients with rapid aortic stenosis progression compared to patients with slow aortic stenosis progression [28]. Histologic evidence of an active inflammatory process in the valve leaflets in aortic stenosis raises the possibility that inflammation within the valve could influence the rate of disease progression [29,30].…”

Aortic valve stenosis: an active atheroinflammatory process

“…In addition, the serum levels of soluble E-selectin have been found to be elevated in patients with aortic valve stenosis and to decline after successful valve replacement, supporting the idea that aortic valve stenosis represents a systemic inflammatory condition [21]. In this sense, other signs of systemic inflammation, such as elevated plasma concentrations of C-reactive protein, have also been described in patients with aortic valve stenosis [23]. C-reactive protein is also present in stenotic aortic valves themselves [24] and may participate in valve calcification, since, in an in-vitro simulating model, rising C-reactive protein levels progressively increased the rate of aortic-wall calcification [25].…”