Relation of common allelic variation at vitamin D receptor locus to bone mineral density and postmenopausal bone loss: cross sectional and longitudinal population study

Jorgensen, Hildegard; Scholler, Jean; Sand, J C; Bjuring, M; Hassager, Christian; Christiansen, Claus

doi:10.1136/bmj.313.7057.586

Cited by 66 publications

(53 citation statements)

References 22 publications

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“…The only positive association, although weak, was found for the haplotype 'bAT', with lower BMD in the femoral neck. Another large-scale association study (Jorgensen et al 1996) also could not establish a relationship between the VDR genotypes and BMD at the lumbar spine, hip and forearm or with postmenopausal bone loss. Even among the studies with positive findings, contradictory results exist regarding the effects of the VDR alleles on phenotypes.…”

Section: Molecular Genetics Of Osteoporosis · Y-z Liu and Others 159mentioning

confidence: 97%

Molecular studies of identification of genes for osteoporosis: the 2002 update

Liu¹,

Liu²,

Recker³

et al. 2003

Journal of Endocrinology

213

168

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We aim to give a comprehensive review, updated to 2002, of the most important and representative molecular genetic studies, performed mainly within the past decade, that aimed to identify the gene(s) involved in osteoporosis. Early reviews were largely confined to association studies in humans, but we review here, separately, the results of both association and linkage studies in humans, and quantitative trait locus (QTL) mapping in animal models. The main results of all the studies are tabulated for comparison and ease of reference, and to provide a comprehensive retrospective view of molecular genetics studies of osteoporosis. The most striking findings and the most representative studies are singled out for comment regarding the immediacy of their influence on present understanding of the genetics of osteoporosis and on the current status of genetic research in osteoporosis. This is particularly relevant for studies on the association of the vitamin D receptor (VDR) gene, for which there has been a large body of studies and reviews published. The format adopted by this review should be ideal for accommodating future new advances and studies in a fairly young field that is still developing rapidly.

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Section: Molecular Genetics Of Osteoporosis · Y-z Liu and Others 159mentioning

confidence: 97%

Molecular studies of identification of genes for osteoporosis: the 2002 update

Liu¹,

Liu²,

Recker³

et al. 2003

Journal of Endocrinology

213

168

View full text Add to dashboard Cite

show abstract

“…No entanto, outros trabalhos mostraram resultados conflitantes (25)(26)(27)(28), enfraquecendo a importân-cia do polimorfismo do gene da vitamina D na gênese da Osteoporose. Diferenças raciais, étnicas e ambientais entre as populações estudadas e o envolvimento de outros genes (herança poligênica) podem estar contribuindo para esta discordância de resultados (29).…”

Section: Genéticaunclassified

Fatores envolvidos no pico de massa óssea

Brandão

Vieira

1999

Arq Bras Endocrinol Metab

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A massa óssea de um indivíduo adulto, que está estreitamente relacionada ao risco de fraturas osteoporóticas, depende da diferença entre o pico de massa óssea alcançado no final do período de maturação sexual e esquelética, e as perdas acumuladas durante a vida. A enorme variabilidade observada no pico de massa óssea da adolescência está relacionada, principalmente, a fatores genéticos, mas também a parâmetros antropométricos, como peso e altura, hábitos dietéticas, influências hormonais diversas, atividade física, uso de medicamentos e doenças intercorrentes. A identificação dos fatores envolvidos na aquisição do pico de massa óssea na infância e adolescência e a compreensão deste longo período de maturação esquelética, permitirão a criação de estratégias para prevenção da osteoporose. (Arq Bras Endocrinol Metab 1999;43/6: 401-408) Unitermos: Pico de massa óssea; Densidade mineral óssea em crianças e adolescentes ABSTRACT Bone mass in the adult life, which is closely related to osteoporotic fracture risk, depends on the differences between the peak bone mass attained at the end of the sexual and skeletal maturation and the rate of involutional bone mass. The great variability in peak bone mass observed at adolescence is related not only to genetic factors, but also to diet, hormonal status, anthropometric variables, as weight and height, physical activity, drugs and intercurrent diseases. The identification of the factors involved with the acquisition of the peak bone mass and the comprehension of this long period of skeletal maturation will indicate strategies for prevention of osteoporosis. (Arq Bras Endocrinol Metab 1999;43/6: 401-408) Keywords: Peak bone mass; BMD in children and adolescents A INCIDÊNCIA DE FRATURAS OSTEOPORÓTICAS está estreitamente relacionada à massa óssea do indivíduo, que depende tanto da velocidade de perda durante a vida quanto da quantidade de tecido ósseo presente no final da puberdade e início da vida adulta. A enorme variância no pico de massa óssea é explicada não só por fatores hereditários, como também por sexo, raça, hábitos dietéticos, atividade física, influências hormonais diversas, composição corporal de massa magra e gordurosa, doenças intercorrentes, uso crônico de medicamentos. A compreensão do longo processo de maturação óssea que ocorre na infância e adolescência vai permitir identificar os fatores passíveis de alguma intervenção e a criação de estratégias para prevenção precoce da osteoporose. Se o ganho mineral ósseo puder ser otimizado durante a puberdade, é provável que o indivíduo adulto esteja menos susceptível a sofrer as devastadoras complicações da osteoporose.

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“…This approach is strongly supported and complemented by breeding and genome screening studies in mouse models of high and low bone mass (106, 239 -241) and of early senescence (221,242,243). 248). Some of the reported differences in the apparent strength and even direction of the vitamin D allelic effects may relate to the genetic backgrounds in different studies and environmental factors such as calcium and vitamin D intakes, as discussed above.…”

Section: December 1999mentioning

confidence: 99%