Relation of dietary fat and fiber to elevation of C-reactive protein

King, Dana E.; Egan, Brent M.; Geesey, Mark E.

doi:10.1016/j.amjcard.2003.08.020

Cited by 273 publications

(202 citation statements)

References 19 publications

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“…We did not find an association between dietary fiber intake and hs-CRP in the current study, which is in contrast to other studies that examined this association in mixed gender samples [20][21][22]. In an analysis of 1999-2000 NHANES data from both men and women, with 67% of the study population <56 years, King and colleagues [21] found that subjects in the highest quartile of total fiber consumption had a lower risk of elevated hs-CRP than did subjects in the lowest quartile (OR: 0.58; 95% CI: 0.38, 0.88).…”

Section: Discussioncontrasting

confidence: 99%

“…Given the strong evidence that systemic inflammation markers is associated with risk of diabetes within the same study population [13], this study suggests a diet high in fiber may play a role in reducing inflammation and thus risk of diabetes for postmenopausal women. In addition, daily total dietary fiber intake was only 16 grams in this study and others [20,21,60], while 20-35 g/day has been recommended by the current dietary guidelines [61]. Therefore, there is significant room for engaging patients in nutrition education programs focusing on behavior modification and dietary fiber; it is never too late for diabetes prevention even among postmenopausal women with average age over 60 years old.…”

Section: Resultsmentioning

confidence: 54%

“…In an analysis of 1999-2000 NHANES data from both men and women, with 67% of the study population <56 years, King and colleagues [21] found that subjects in the highest quartile of total fiber consumption had a lower risk of elevated hs-CRP than did subjects in the lowest quartile (OR: 0.58; 95% CI: 0.38, 0.88). Our group previously reported an inverse association between hs-CRP and total fiber, soluble, and insoluble fiber intake in a healthy adult sample that was largely Caucasian, 48% female, and had a mean age of 48 years [22], with an average hs-CRP level of 1.8 mg/L.…”

Section: Discussionmentioning

confidence: 99%

“…Second, dietary fiber may prevent inflammation by altering adipocytokines in adipose tissue and increasing enterohepatic circulation of lipids and lipophilic compounds [19]. The link between dietary fiber intake and reduced hs-CRP has been observed in several recent studies, including two analyses using cross-sectional data from NHANES 1999-2000 [20,21], an analysis using a longitudinal cohort of 524 healthy adults [22], and a small clinical trial [23]. However, one study has examined the association of dietary fiber with the pro-inflammatory cytokines IL-6 and TNF-α [24] and there is increasing clinical and experimental evidence for an important independent role of TNF-α-R2 signaling in chronic inflammatory conditions [25].…”

Section: Introductionmentioning

confidence: 99%

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Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study

et al. 2008

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Objective-Systemic inflammation may play an important role in the development of atherosclerosis, type 2 diabetes, and some cancers. Few studies have comprehensively assessed the direct relationships between dietary fiber and inflammatory cytokines, especially in minority populations. Using baseline data from 1,958 postmenopausal women enrolled in the Women's Heath Initiative Observational Study, we examined cross-sectional associations between dietary fiber intake and markers of systemic inflammation (including serum C-reactive protein (hs-CRP), interleukin 6 (IL-6), and tumor necrosis factor α receptor 2 (TNF-α-R2)), as well as differences in these associations by ethnicity.Method-Multiple linear regression models were used to assess the relationship between fiber intake and makers of systemic inflammation.Results-After adjustment for covariates, intake of dietary fiber were inversely associated with both IL-6 (P values for trend were 0.01 for total fiber, 0.004 for soluble fiber, and 0.001 for insoluble fiber) and TNF-α-R2 (P values for trend were 0.002 for total, 0.02 for soluble, and <0.001 for insoluble fiber). Although the sample sizes were small in minority Americans, results were generally Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusions-These findings lend support to the hypothesis that a high-fiber diet is associated with lower plasma levels of IL-6 and TNF-α-R2. Contrary to previous reports, however, there was no association between fiber and hs-CRP among postmenopausal women. Future studies on the influence of diet on inflammation should include IL-6 and TNF-α-R2 and enroll participants from ethnic minorities. NIH Public Access

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Section: Discussioncontrasting

confidence: 99%

Section: Resultsmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study

et al. 2008

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“…Results have been mixed. In the National Health and Nutrition Examination Survey iv trial, levels of highsensitivity C-reactive protein, an inflammatory marker, were inversely related to the levels of serum antioxidant micronutrients including Se [179]. However, results of antioxidant supplementation trials have largely been disappointing, demonstrating little effect of Se and vitamins E and C on gastric cancer [180] and no effect of vitamin E and β-carotene on the prevention of heart disease [181].…”

Section: History Of Clinical Trials Of Antioxidants In Other Diseasesmentioning

confidence: 99%

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

Cantin

White

Cross

et al. 2007

Free Radical Biology and Medicine

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Although great strides are being made in the care of individuals with cystic fibrosis (CF), this condition remains the most common fatal hereditary disease in North America. Numerous links exist between progression of CF lung disease and oxidative stress. The defect in CF is the loss of function of the transmembrane conductance regulator (CFTR) protein; recent evidence that CFTR expression and function are modulated by oxidative stress suggests that the loss may result in a poor adaptive response to oxidants. Pancreatic insufficiency in CF also increases susceptibility to deficiencies in lipophilic antioxidants. Finally the airway infection and inflammatory processes in the CF lung are potential sources of oxidants that can affect normal airway physiology and contribute to the mechanisms causing characteristic changes associated with bronchiectasis and loss of lung function. These multiple abnormalities in the oxidant/antioxidant balance raise several possibilities for therapeutic interventions that must be carefully assessed. IntroductionCystic fibrosis (CF) is the most common fatal disease caused by a single gene defect in Europe and North America [1,2]. The defective gene was identified in 1989 [3][4][5] and shown to encode the cystic fibrosis trans-membrane conductance regulator protein (CFTR). CFTR is a cyclic AMP-regulated anion channel with greatest selectivity for chloride, and bicarbonate [6][7][8]. Furthermore, CFTR regulates sodium transport across epithelial membranes through interactions with the epithelial sodium channel ENaC [9], and facilitates the trans-membrane export of the small organic anionic peptide glutathione [10]. The expression of CFTR is located in the apical membrane of epithelial cells that line mucous membranes and submucosal glands ☆ A list of participants may be found in the Acknowledgments.

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Effect of a High-Fiber Diet vs a Fiber-Supplemented Diet on C-Reactive Protein Level

King

Egan²,

Woolson³

et al. 2007

Arch Intern Med

214

145

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Background: Diets high in fiber are associated with lower levels of inflammatory markers. This study examined the reduction in inflammation from a diet supplemented with fiber compared with a diet naturally high in fiber. Methods: Randomized crossover intervention trial of 2 diets, a high-fiber (30-g/d) Dietary Approaches to Stop Hypertension (DASH) diet or fiber-supplemented diet (30 g/d), after a baseline (regular) diet period of 3 weeks. There were 35 participants (18 lean normotensive and 17 obese hypertensive individuals) aged 18 to 49 years. Results: The study included 28 women and 7 men; 16 (46%) were black, the remainder white. The mean (SD) fiber intake on baseline diets was 11.9 (0.3) g/d; on the high-fiber DASH diet, 27.7 (0.6) g/d; and on the supplemented diet, 26.3 (0.4) g/d. Overall, the mean Creactive protein (CRP) level changed from 4.4 to 3.8 mg/L (−13.7%; P=.046) in the high-fiber DASH diet group and to 3.6 mg/L (−18.1%) in the fiber-supplemented diet group

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Relation of dietary fat and fiber to elevation of C-reactive protein

Cited by 273 publications

References 19 publications

Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study

Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

Effect of a High-Fiber Diet vs a Fiber-Supplemented Diet on C-Reactive Protein Level

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