Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans*1

LI, R

doi:10.1016/j.amjhyper.2004.02.013

Cited by 119 publications

(86 citation statements)

References 32 publications

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“…We observed that the 298Asp allele was not associated with BP, albuminuria or with fasting and postload glucose levels. However, as previously reported for Anglo-Celtic 17 and African-Americans, 26 in Venezuelans, the Glu298Asp polymorphism was found associated with modest increases in triglyceride and LDL-cholesterol (present study). It thus appears that irrespective of ethnicity, the presence of the Glu298Asp polymorphism carries an increased prevalence of cardiovascular risk factors (higher BMI, LDL-cholesterol and triglycerides).…”

Section: Ethnicity and Enos Polymorphismssupporting

confidence: 88%

“…9,12,13,23,26,34,35 The frequency of the T allele in Venezuelans was comparable to that described for Caucasians, since the T allele was found in 30% of the Venezuelan subjects studied (present study).…”

Section: Ethnicity and Enos Polymorphismssupporting

confidence: 87%

“…However, tracking of the 4a allele with lower HDL-and higher LDL-cholesterol was reported in Anglo-Celtics 17 and with higher LDLcholesterol in hypertensive African-Americans. 26 In our study, in Venezuelans, the 4a allele was associated with increased LDL levels. It thus appears that the presence of the 4a/b polymorphism carries an increased prevalence of elevated LDLcholesterol.…”

Section: Ethnicity and Enos Polymorphismssupporting

confidence: 49%

“…[26][27][28][29] However, such an association was not found in another studies. 10,17 In our work, no association was found between the a allele and the baseline BP.…”

Section: Ethnicity and Enos Polymorphismsmentioning

confidence: 73%

“…The a allele was found more frequently in African-Americans (27-31%) than in Caucasians (16-18%) or Japanese (10-13%). 9,26,[34][35][36][37] Once again the frequency of a allele in Venezuelan subjects most closely compared to that of the Caucasians, since it was found in 18% of the Venezuelan subjects studied.…”

Section: Ethnicity and Enos Polymorphismsmentioning

confidence: 85%

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Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics

et al. 2004

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Mutations in the endothelial nitric oxide synthase (eNOS) gene may be associated with abnormal nitric oxide (NO) production and cardiovascular diseases. In this study, we investigated the prevalence of two eNOS polymorphisms, the Glu298Asp variant on exon 7, and the 4a/b variable number of tandem repeats (VNTR) on intron 4, and their association with blood pressure (BP), NO production, salt sensitivity and cardiovascular risk factors in healthy Venezuelans. The prevalence of both polymorphisms in Venezuelans was comparable to that described for Caucasians, but significantly different from that known for African-Americans and Japanese. The 4a/b genotype was associated with reduced levels of NO metabolites (25% decrease), larger BP lowering in response to salt restriction (9.0 vs 4.8 mmHg, Po0.05), greater prevalence of salt sensitivity (39% in 4a/b and 27% in 4b/b; Po0.05) and with higher LDL-cholesterol levels. The Glu298T polymorphism did not affect NO production, nor it was associated with salt sensitivity. Glu298Asp polymorphism was positively associated with higher weight, triglycerides and LDL-cholesterol. Neither polymorphism was associated with changes in fasting or postload serum glucose, BP, obesity and albuminuria. In conclusion, the prevalence of eNOS polymorphisms is strongly determined by ethnic factors. The 4a/b gene polymorphism could be a genetic susceptibility factor for the BP response to salt intake and for the genetic control of NO production. The reduced NO production in subjects with the 4a/b genotype may be responsible for the increased sensitivity of their BP to salt.

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Section: Ethnicity and Enos Polymorphismssupporting

confidence: 88%

Section: Ethnicity and Enos Polymorphismssupporting

confidence: 87%

Section: Ethnicity and Enos Polymorphismssupporting

confidence: 49%

“…[26][27][28][29] However, such an association was not found in another studies. 10,17 In our work, no association was found between the a allele and the baseline BP.…”

Section: Ethnicity and Enos Polymorphismsmentioning

confidence: 73%

Section: Ethnicity and Enos Polymorphismsmentioning

confidence: 85%

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Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics

et al. 2004

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Increased levels of circulating endothelial progenitor cells and circulating endothelial nitric oxide synthase in patients with gliomas

Zheng

Hop

Luider

et al. 2007

Annals of Neurology

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First survey of the three gene polymorphisms (PON1 Q192R, eNOS E298D and eNOS C‐786T) potentially associated with coronary artery spasm in African populations and comparison with worldwide data

Fujihara

Yasuda

Kawai

et al. 2011

Cell Biochemistry & Function

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Three polymorphisms, Paraoxonase 1 (PON1) Q192R (C/G), endothelial nitric oxide synthase (eNOS) E298D (G/T) and eNOS T-786C have been suggested to be potentially associated with coronary artery spasm in Japanese patients. Data on worldwide populations are needed to clarify whether these associations could hold true for other populations. However, few data are available especially in Africans, spasm of which has been suggested to be an aetiology of myocardial infarction. Therefore, these polymorphisms were investigated in three Africans, Ovambos (n = 123), Ghanians (n = 118) and Xhosas (n = 96), together with Japanese (n = 96), by using polymerase chain reaction-restriction fragment length polymorphism analysis. Genotype-distributions of all these SNPs in African populations were significantly different from those in Caucasians, whereas were similar to those in Japanese population. African populations exhibit relatively higher frequency of spasm-associated G192 allele in PON1 Q192R being similar to Japanese population, however frequencies of spasm-associated T298 allele and -C786 allele in SNP eNOS E298D and T-786C, respectively, were conversely lower in Africans than Caucasians. Although healthy subjects have been recruited in this study, these findings may provide genetic background for elucidation of aetiology of spasm.

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Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans*1

Cited by 119 publications

References 32 publications

Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics

Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics

Increased levels of circulating endothelial progenitor cells and circulating endothelial nitric oxide synthase in patients with gliomas

First survey of the three gene polymorphisms (PON1 Q192R, eNOS E298D and eNOS C‐786T) potentially associated with coronary artery spasm in African populations and comparison with worldwide data

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