Relation of Endothelium, Thrombogenesis, and Hemorheology in Systemic Hypertension to Ethnicity and Left Ventricular Hypertrophy

Lip, Gregory Y.H.; Blann, Andrew D.; Jones, A. F.; Lip, Peck Lin; Beevers, D. G.

doi:10.1016/s0002-9149(97)00749-2

Cited by 157 publications

(110 citation statements)

References 20 publications

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“…As well as confirming the presence of endothelial, platelet, and hemorheological abnormalities in hypertension, 4,5,19 the present study shows a relationship between TOD and the endothelial marker von Willebrand factor, but not soluble P-selectin and conventional hemorheological markers, in hypertensive patients. The exact mechanisms by which this occurs or, indeed, whether TOD promotes endothelial damage or vice versa is unclear.…”

Section: Discussionsupporting

confidence: 85%

Von Willebrand Factor, Soluble P-Selectin, and Target Organ Damage in Hypertension

et al. 2002

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Abstract-To investigate the relationship between soluble markers of platelet, endothelial and rheological function, and target organ damage and their response to intensified management in a population of middle-age hypertensive patients at high risk of cardiovascular complications, we studied 382 consecutive patients (308 men; mean age, 63 years, SD 8) along with 60 normotensive controls free of cardiovascular disease. Patients were divided into those with target organ damage (TOD; nϭ107) and those free of end-organ damage. Plasma levels of soluble P-selectin (sP-sel), a marker of platelet activation, and von Willebrand factor (vWF), an index of endothelial damage/dysfunction (both enzyme-linked immunosorbent assay), and the rheological indices fibrinogen, plasma viscosity, hematocrit, platelet, and white cell count were measured. In 53 patients, variables were further measured after 6 months of intensified cardiovascular risk management. Patients with TOD had significantly higher vWF, 137 (SD 33) versus 125 (SD 33) IU/dL (Pϭ0.002,) and a greater proportion of smokers, 31% versus 16% (Pϭ0.002). There were no statistically significant differences in plasma viscosity, fibrinogen, hematocrit, white blood cell count, platelet count, or sP-sel between the 2 subgroups. In multivariate analysis, vWF was a significant independent predictor for TOD. After 6 months of intensified management in 53 patients who entered the trial, there were significant reductions in systolic blood pressure, total cholesterol, hematocrit, plasma viscosity, sP-sel, and vWF (all PϽ0.01) but no significant change in fibrinogen.

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Section: Discussionsupporting

confidence: 85%

Von Willebrand Factor, Soluble P-Selectin, and Target Organ Damage in Hypertension

et al. 2002

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“…Little is known about racial differences in fibrinolytic factors; however, whites have been found to have higher t-PA antigen levels than other racial groups and lower PAI-1 antigen levels than African-Americans. 36,37 Consistent with these findings, we observed higher baseline levels of t-PA antigen in whites compared with African-Americans who were consuming the same control diet. Thus, lower levels of t-PA antigen in African-Americans in this study are not likely due to differences in dietary patterns or salt intake.…”

Section: Journal Of Human Hypertensionsupporting

confidence: 78%

The impact of angiotensin II receptor blockade and the DASH diet on markers of endogenous fibrinolysis

et al. 2002

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Hypertension is associated with impaired fibrinolysis. Both angiotensin receptor blockers (ARB) and the DASH (Dietary Approaches to Stop Hypertension) diet effectively lower blood pressure in hypertensive patients. Some evidence suggests that treatment with ARBs could increase fibrinolysis, however, data is conflicting. The impact of the DASH diet on fibrinolytic parameters is not known. Fifty-five hypertensive participants (35 African-American, 20 white) were randomly assigned to receive 8 weeks of either a control diet or the DASH diet. The diets did not differ in sodium content (approximately 3 g/day). Within each diet, individuals were randomly assigned to receive losartan or placebo for 4 weeks in double-blind, cross-over fashion. Tissue plasminogen activator (t-PA) antigen, t-PA activity, plasminogen activator inhibitor-1 (PAI-1) activity and plasma renin activity (PRA) were measured at the end of a 2-

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“…6,7,10 Antithrombotic drugs such as aspirin, dipyridamole, clopidogrel, ticlopidine, GPIIb/IIIa inhibitors and oral anticoagulants may have a particular role in the treatment of hypertensive patients. This antithrombotic action might prevent death and/or cardiovascular thrombotic events.…”

Section: Discussionmentioning

confidence: 99%

“…5 Increasing evidence also points towards a prothrombotic or hypercoagulable state conferred by the presence of hypertension, as evident by abnormalities of coagulation, 6,7 platelets 6,7 and endothelial function [8][9][10] in such patients.…”

Section: Introductionmentioning

confidence: 99%

Antithrombotic therapy in hypertension: a Cochrane Systematic review

Felmeden

Lip

2005

J Hum Hypertens

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Relation of Endothelium, Thrombogenesis, and Hemorheology in Systemic Hypertension to Ethnicity and Left Ventricular Hypertrophy

Cited by 157 publications

References 20 publications

Von Willebrand Factor, Soluble P-Selectin, and Target Organ Damage in Hypertension

Von Willebrand Factor, Soluble P-Selectin, and Target Organ Damage in Hypertension

The impact of angiotensin II receptor blockade and the DASH diet on markers of endogenous fibrinolysis

Antithrombotic therapy in hypertension: a Cochrane Systematic review

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