Relation of ferritin levels with symptom ratings and cognitive performance in children with attention deficit–hyperactivity disorder

Öner, Özgür; Alkar, Özden Yalçınkaya; Öner, Pınar

doi:10.1111/j.1442-200x.2007.02496.x

Cited by 66 publications

(71 citation statements)

References 29 publications

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“…Decreased ferritin has been associated with other psychiatric disorders, such as attention deficit-hyperactivity, schizophrenia and major depression. [30][31][32] Studies have described direct proinflammatory effects of iron deficiency on macrophages and foam cells. 33 Other methods can be used to estimate cellular iron stores in patients.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder

Chiarani

Tramontina

Ceresér

et al. 2013

Rev. Bras. Psiquiatr.

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Objective: To evaluate serum levels of different biomarkers associated with cardiovascular disease in patients with bipolar disorder (BD). Patients were prospectively evaluated in two separate instances: during acute mania and after remission of manic symptoms. All measurements were compared with those of healthy controls. Methods: The study included 30 patients with BD and 30 healthy controls, matched for gender and age. Biochemical parameters evaluated included homocysteine (Hcy), folic acid, vitamin B12, ferritin, creatine kinase (CK) and C-reactive protein (CRP). Results: Hcy levels were significantly higher in the BD patients, both during mania and after achieving euthymia. When Hcy was adjusted for body mass index, there was no significant difference between patients and controls. Ferritin was the only marker that showed a significant decrease during mania when compared to both euthymic patients and controls. There were no significant differences for folate, vitamin B12, CK and CRP. Conclusions: These findings do not show an association between alterations of markers of cardiovascular risk during manic episodes. Further studies are necessary to determine factors and mechanisms associated with cardiovascular risk in patients with BD.

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Section: Discussionmentioning

confidence: 99%

Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder

Chiarani

Tramontina

Ceresér

et al. 2013

Rev. Bras. Psiquiatr.

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“…Other studies have focused on the utility of iron supplementation in ADHD, with conflicting results [11]. One study investigated the relationship between iron levels and cognitive functioning of children with ADHD [12]. Results of that study reported no significant correlations between ferritin level and performance in vigilance and sustained attention tasks, executive function tests like planning and organization, complex problem solving, set shifting and response monitoring.…”

Section: Introductionmentioning

confidence: 99%

Relationship of Ferritin to Symptom Ratings Children with Attention Deficit Hyperactivity Disorder: Effect of Comorbidity

Öner¹,

Oner

2007

Child Psychiatry Hum Dev

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Our aim was to investigate the relation between behavioral symptoms and hematological variables which are related with iron deficiency and anemia, ferritin, hemoglobin, mean corpuscular volume (MCV), and reticulosite distribution width (RDW) in children and adolescents with pure Attention Deficit Hyperactivity Disorder (ADHD) or ADHD comorbid with other psychiatric disorders. The sample consisted of 151 subjects with ADHD, 45 of these subjects had other comorbid conditions. Conners Parent (CPRS) and Teacher Rating Scales (CTRS) were obtained. Comorbid ADHD subjects had lower mean hemoglogin and MCV. In the ADHD group in general, CPRS and CTRS Total scores were significantly negatively correlated with ferritin level. When only pure ADHD subjects were taken into account, the correlations did not reach statistical signifance. Overall, these results suggested that lower ferritin level was associated with higher behavioral problems reported by both parents and teachers. Presence of comorbid conditions might increase the effect of lower iron stores on behavioral measures.

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“…In addition, these children exhibit more anxiety, depression, and social problems, and show an impaired prolactin response to stress, long after iron repletion (Lozoff et al 2000;Felt et al 2006). ID indicated by low serum ferritin concentration has been linked to the severity of attention-deficit/hyperactivity disorder (ADHD) and resistance to psychostimulant treatment (Konofal et al 2004Oner et al 2008;). Moreover, low mean corpuscular volume (a marker of ID) at *3 years of age has been associated with reduced response to psychostimulants nearly 3 years later (Turner et al 2012).…”

mentioning

confidence: 99%

Iron Deficiency in Pediatric Patients in Long-Term Risperidone Treatment

Calarge

Ziegler²

2013

Journal of Child and Adolescent Psychopharmacology

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Objective: Atypical antipsychotics, increasingly used in children and adolescents, modulate brain dopamine. Iron plays a critical role in dopaminergic signaling. Therefore, we explored whether body iron status is related to psychiatric symptom severity, treatment response, and tolerability following extended antipsychotic therapy. Methods: Between November 2005 and August 2009, medically healthy 7-17-year-old risperidone-treated participants enrolled in a cross-sectional study examining the long-term safety of this antipsychotic. Anthropometric measurements were obtained. Psychiatric symptom severity and dietary intake were assessed. Serum ferritin, transferrin receptor, and prolactin concentrations were measured. Linear multivariable regression analysis tested the association among body iron, symptom severity, the dose of risperidone and psychostimulants, and serum prolactin concentration. Results: The sample consisted of 115 patients (87% males) with a mean (-SD) age of 11.6 (-2.8) years. The majority had externalizing disorders, and they had taken risperidone for 2.4 (-1.7) years. Body iron was low, with 45% having iron depletion and 14% having iron deficiency. Iron status was inversely associated with weight gain during risperidone treatment and with interleukin-6. Body iron was neither associated with psychiatric symptom severity nor with the daily dose of risperidone and psychostimulants. It was, however, inversely associated with prolactin concentration, which was nearly 50% higher in the iron-deficient group. Conclusions: Iron depletion and deficiency are prevalent in children and adolescents chronically treated with risperidone. Iron deficiency accentuates the antipsychotic-induced elevation in prolactin. Future studies should confirm this finding and investigate the potential benefit of iron supplementation in antipsychotic-treated patients.

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Relation of ferritin levels with symptom ratings and cognitive performance in children with attention deficit–hyperactivity disorder

Cited by 66 publications

References 29 publications

Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder

Homocysteine and other markers of cardiovascular risk during a manic episode in patients with bipolar disorder

Relationship of Ferritin to Symptom Ratings Children with Attention Deficit Hyperactivity Disorder: Effect of Comorbidity

Iron Deficiency in Pediatric Patients in Long-Term Risperidone Treatment

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