Relation of glycated hemoglobin and vitamin D deficiency with erectile dysfunction in patients with type 2 diabetes mellitus

Merder, Erkan; Çulha, Mehmet Gökhan; Ermeç, Bahadır; KARAKANLI, Musab Ümeyir; Adaş, Mine

doi:10.1111/and.14076

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…There were three studies that divided patients with ED into subgroups according to the score of IIEF-5 and compared the level of vitamin D between patients with DMED and DM [21][22][23]. WMD was calculated to compare vitamin D levels between DMED patients and diabetic patients in different subgroups.…”

Section: Subgroup Analysis Of Vitamin D and Ed Severitymentioning

confidence: 99%

Serum Vitamin D Level and Erectile Dysfunction in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Liu¹,

Wu²,

Zhang³

et al. 2022

Urol Int

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Introduction: A few studies involved the relationship between vitamin D and diabetes mellitus (DM) with erectile dysfunction (ED), and no meta-analysis was conducted to pool these data. The main purpose of our study was to examine the changes in serum vitamin D levels in patients with DM combined with ED. Methods: An extensive search was performed, including the following words: “erectile dysfunction,” “diabetes,” and “vitamin D.” Databases, including Cochrane Library, PubMed, and Web of Science, were retrieved to identify studies published up to September 30, 2021. Four studies were eligible for our meta-analysis. Results: The weighted mean difference and their corresponding 95% confidence intervals were calculated to the data we selected. The results showed that the level of vitamin D in DM with ED was significantly lower (12.5 nmol/mL) than patients with diabetes alone (p = 0.002). Conclusion: Our novel meta-analysis suggests that vitamin D may be a risk factor for DM with ED, which can provide a new idea for the treatment and prevention of DM with ED.

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Section: Subgroup Analysis Of Vitamin D and Ed Severitymentioning

confidence: 99%

Serum Vitamin D Level and Erectile Dysfunction in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Liu¹,

Wu²,

Zhang³

et al. 2022

Urol Int

View full text Add to dashboard Cite

show abstract

“…It is converted into its active form, calcitriol, which binds to vitamin D receptors in various tissues, including those involved in erectile function. Several studies have explored the potential link between vitamin D deficiency and the risk of ED ( Barassi et al, 2014 ; Basat et al, 2018 ; Arıman et al, 2021 ; Canguven and Al Malki, 2021 ; Kim and Cho, 2022 ). Some have suggested that low levels of vitamin D may contribute to endothelial dysfunction, inflammation, and impaired nitric oxide production, all of which are factors that contribute to the development of ED ( Crafa et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D level and erectile dysfunction: a causal relationship? Findings from a two-sample Mendelian randomization study

Sun,

Shen,

Dong

et al. 2024

Front. Mol. Biosci.

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BackgroundSerum 25-hydroxyvitamin D level is associated with erectile dysfunction (ED) in observational studies. However, whether there is a causal association between them remains uncertain.ObjectiveConduct a two-sample Mendelian randomization (MR) analysis to investigate the causal effect between serum 25-hydroxyvitamin D level and ED risk.MethodGenome-wide association study (GWAS) data of serum 25-hydroxyvitamin D levels comprising 6,896,093 single nucleotide polymorphisms (SNP) from 496,949 people of European ancestry were regarded as exposure for the MR analysis. Additional GWAS data involving 9,310,196 SNPs of 6,175 European ED cases and 217,630 controls were used as outcome data. The MR-Egger, inverse variance weighted (IVW) method, weighted median, simple mode, and weighted mode were employed to evaluate causal effects, among which IVW was the primary MR analysis method. The stability of the MR analysis results was confirmed by a heterogeneity test, a horizontal pleiotropy test, and the leave-one-out method.ResultThere were 103 SNPs utilized as instrumental variables (p < 5 × 10−8). The results of MR analysis showed no causal effects of serum 25(OH) D concentration on ED risks (IVW; OR = 0.9516, 95% CI = 0.7994 to 1.1328, p = 0.5772). There was no heterogeneity and pleiotropy in the statistical models.ConclusionThe present MR study did not support a causal association for genetically predicted serum 25-hydroxyvitamin D concentration in the risk of ED in individuals of European descent.

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Relation of glycated hemoglobin and vitamin D deficiency with erectile dysfunction in patients with type 2 diabetes mellitus

Cited by 2 publications

References 29 publications

Serum Vitamin D Level and Erectile Dysfunction in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Serum Vitamin D Level and Erectile Dysfunction in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Serum 25-hydroxyvitamin D level and erectile dysfunction: a causal relationship? Findings from a two-sample Mendelian randomization study

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