Relation of Interatrial Block to Cognitive Impairment in Patients ≥ 70 Years of Age (From the CAMBIAD Case-control Study)

Herrera, Cristian; Bruña, Vanesa; Díez‐Villanueva, Pablo; Formiga, Francesç; Torres, Rosa; Carreras, José; Ayala, R.; Martín‐Sánchez, Francisco Javier; Bayés‐Genís, Antoni; Elosúa, Roberto; Bayés-de-Luna, Antoni; Martínez‐Sellés, Manuel; investigators, Cambiad

doi:10.1016/j.amjcard.2020.09.008

Cited by 12 publications

(15 citation statements)

References 30 publications

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“…Results suggest interatrial block (including both partial and advanced interatrial block) may be a risk factor for cognitive impairment (Martinez-Selles et al, 2020). This finding was also true for patients with mild cognitive impairment (Herrera et al, 2020).…”

Section: Electrocardiographic Abnormalitiesmentioning

confidence: 74%

Atrial cardiopathy and cognitive impairment

Myers

Jiménez‐Ruiz

Sposato

et al. 2022

Front. Aging Neurosci.

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Cognitive impairment involves complex interactions between multiple pathways and mechanisms, one of which being cardiac disorders. Atrial cardiopathy (AC) is a structural and functional disorder of the left atrium that may be a substrate for other cardiac disorders such as atrial fibrillation (AF) and heart failure (HF). The association between AF and HF and cognitive decline is clear; however, the relationship between AC and cognition requires further investigation. Studies have shown that several markers of AC, such as increased brain natriuretic peptide and left atrial enlargement, are associated with an increased risk for cognitive impairment. The pathophysiology of cognitive decline in patients with AC is not yet well understood. Advancing our understanding of the relationship between AC and cognition may point to important treatable targets and inform future therapeutic advancements. This review presents our current understanding of the diagnosis of AC, as well as clinical characteristics and potential pathways involved in the association between AC and cognitive impairment.

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Section: Electrocardiographic Abnormalitiesmentioning

confidence: 74%

Atrial cardiopathy and cognitive impairment

Myers

Jiménez‐Ruiz

Sposato

et al. 2022

Front. Aging Neurosci.

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“…Patients with cognitive impairment had longer P-wave duration, higher prevalence of IAB, and higher prevalence of advanced IAB when compared to controls. IAB was independently associated with mild cognitive impairment, both for partial and advanced IAB but with a stronger association in the case of advanced IAB 21 .…”

Section: Iabs and Cognitive Impairmentmentioning

confidence: 84%

Neurological complications of interatrial blocks and BayesÓ? syndrome

Farina¹,

Miranda-Arboleda²,

Lomini³

et al. 2022

RMN

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Interatrial blocks (IABs) are a variety of abnormalities in the interatrial conduction. Bayes' syndrome is a clinical entity based on the association between advanced IABs and supraventricular tachyarrhythmias, being atrial fibrillation (AF) the most frequent. Due to its negative effects on left atrial electromechanical function, both IABs and Bayes' syndrome are associated with thromboembolic phenomena, causing cardiovascular and neurological complications. In regard to neurological involvement, patients with these conditions have an increased incidence of ischemic events, cognitive impairment, and dementia. These observations triggered the question whether the use of early anticoagulation therapy (before the documentation of AF) could prevent thromboembolic events in patients with IABs diagnosis. This review aims to summarize the most recent evidence describing the association of IABs and Bayes' syndrome with neurological events. Potential early therapeutic options to prevent these undesirable clinical consequences will be also discussed.

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“…We read with great interest the study of Russo et al 1 regarding the prognostic role of interatrial block (IAB) among hospitalized COVID‐19 patients. Although the prognostic role of IAB has been previously described in several settings, 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 this is the first report regarding the association of IAB with a poor prognosis in COVID‐19. The authors found that advanced IAB was an independent predictor of thrombotic events but did not include the data regarding patients with baseline atrial fibrillation.…”

mentioning

confidence: 76%