Relation of kidney function and homocysteine in patients with hypothyroidism

Abstract

Objective: It has been found that both serum homocysteine (Hcy) and serum creatinine levels were increased in hypothyroidism patients. The aim of this study was to investigate the correlation between serum Hcy and kidney function in patients with subclinical hypothyroidism or hypothyroidism. Methods: A total of 448 subjects were enrolled and divided into three groups: hypothyroidism (n=129), subclinical hypothyroidism (n=141), and control group (n=168). Anthropometric information, metabolic parameters, serum Hcy and creatinine levels, and estimated glomerular filtration rate (eGFR) were analyzed. Results: Compared with healthy subjects, patients with subclinical hypothyroidism or hypothyroidism had significantly higher serum Hcy and creatinine levels and lower eGFR level (all P<0.001). Serum Hcy was negatively correlated with eGFR in subclinical hypothyroidism patients (r =-0.220, P=0.009), and in hypothyroidism patients (r =-0.422, P<0.001). After adjusting for age, sex and body mass index, eGFR was still significantly correlated with serum Hcy in subclinical hypothyroidism or hypothyroidism patients (both P<0.05). Levothyroxine treatment resulted in significantly decreased Hcy and increased eGFR in hypothyroidism patients (both P<0.001). The decrease in Hcy was correlated with the increased eGFR after treatment (P=0.001). Conclusion: Serum Hcy was negatively correlated with eGFR in subclinical hypothyroidism or hypothyroidism patients. After levothyroxine treatment, a correlation was found between the decrease in serum Hcy and the increase in eGFR in hypothyroidism patients.

A Micro Radial-Torsional Vibration Ultrasonic Motor Driven by Single-Phase Signal

“…The motor has a no-load speed of 176.5 rpm and a maximum torque of 29.4 mN• m [34]. A compact symmetric coplanar piezoelectric motor for high-speed rotary motors up to 5000 rpm was presented by Borodinas et al [35]. Compared with these motors, the speed of the motor proposed in this paper can reach their highest level.…”

“…Moreover, the processing difficulty and cost are greatly reduced, and laser processing can be used for processing, which makes the processing efficiency higher, and this point has been verified in the latest work. Top rotary speed(r/min) Top torque(mN• m) Qiu et al [32] 5172 0.35 He et al [33] 400 0.3 He et al [21] 1000 0.37 Pan et al [34] 176.5 29.4 Borodinas et al [35] 5000 /…”