Relation of Liver Siderosis to Liver Fibrosis in Hemodialysis Patients With Severe Hyperferritinemia Secondary to High Doses of Intravenous Iron Supplementation

Ibrahim, Walaa H.; Abokresha, Marwa M.; Eldin, Dalia Negm; Abdelal, Sherif M.; Kelani, Abdalla; Aly, Mostafa

doi:10.1053/j.jrn.2022.08.004

Cited by 3 publications

(1 citation statement)

References 20 publications

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“… 12 , 13 Moreover, recently, liver iron accumulation by MRI in patients on dialysis has been shown to increase hepatic proton density fat fraction, with the ability to induce or worsen fatty liver disease 14 and to be associated with liver fibrosis at transient elastography. 15 Therefore, iron overload has become one of the most controversial topics in the management of dialysis-related anaemia. 4 , 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

Relationship between bone marrow iron load and liver iron concentration in dialysis-associated haemosiderosis

Rostoker,

Dekeyser,

Francisco

et al. 2024

eBioMedicine

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Section: Introductionmentioning

confidence: 99%

Relationship between bone marrow iron load and liver iron concentration in dialysis-associated haemosiderosis

Rostoker,

Dekeyser,

Francisco

et al. 2024

eBioMedicine

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Phytate and Kidney Health: The Roles of Dietary Phytate in Inhibiting Intestinal Phosphorus Absorption and Intravenous Phytate in Decreasing Soft Tissue Calcification

Ekramzadeh

Moore

Kalentar-Zadeh

et al. 2023

Journal of Renal Nutrition

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TSAT-Urated Insights: Clarifying the Complexities of Hereditary Hemochromatosis and Its Guidelines

Marcon,

Medeot,

Michelazzi

et al. 2024

Hemato

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Hereditary hemochromatosis (HH) related to HFE-gene mutations is a well-known condition, yet its understanding remains complex. The BIOIRON classification emphasizes that only homozygosity for the C282Y mutation should be considered pathogenic. The penetrance of HFE-related HH is highly variable. Symptoms are often challenging to recognize at the time of presentation, and the systemic involvement may overlap with other diseases. Hyperferritinemia and elevated transferrin saturation levels are still the milestones in HH diagnosis, but they are also common findings in many other clinical conditions. Furthermore, current diagnostic and therapeutic guidelines are not always unequivocal in defining HH patients’ characteristics, as well as treatment management and goals. Our work provides a concise overview of the latest evidence regarding pathogenic mechanisms, clinical picture, differential diagnosis and diagnostic tools. Alongside this, it summarizes and compares the main recommendations from principal guidelines issued by the 2017 Hemochromatosis International Meeting, the American College of Gastroenterology, the European Association for the Study of the Liver, the European Molecular Genetics Quality Network, the DUTCH guidelines, and the British Society for Haematology. Summarizing tables for quick consultation are also provided.

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Relation of Liver Siderosis to Liver Fibrosis in Hemodialysis Patients With Severe Hyperferritinemia Secondary to High Doses of Intravenous Iron Supplementation

Cited by 3 publications

References 20 publications

Relationship between bone marrow iron load and liver iron concentration in dialysis-associated haemosiderosis

Relationship between bone marrow iron load and liver iron concentration in dialysis-associated haemosiderosis

Phytate and Kidney Health: The Roles of Dietary Phytate in Inhibiting Intestinal Phosphorus Absorption and Intravenous Phytate in Decreasing Soft Tissue Calcification

TSAT-Urated Insights: Clarifying the Complexities of Hereditary Hemochromatosis and Its Guidelines

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